BRAF D594H

CI-VAR-00000511Explore in graph →NP_001341538.1:p.Asp594HisNM_001354609.2:c.1780G>CClinVar 375947 CIViC 2832

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
BRAF D594H	(functional)	Functional	D	Supports Gain Of Function	2	submitted	EID7652 An in vitro kinase assay showed that BRAF D594H, a class 3 BRAF mutation, lacked kinase activity as measured by presence of phosphorylated MEK1/2. RAS-dependent activation of MEK1/2 and ERK1/2 was see… (full text at CIViC) PMID 28783719 · Yao et al., 2017 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.