BRAF Asn486_Pro490del

CI-VAR-00000261Explore in graph →NM_004333.6:c.1457_1471del15CIViC 5486

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Neoplasm1
BRAF Asn486_Pro490del	(oncogenic)	Oncogenic	D	Supports Oncogenicity	5	submitted	EID12993 BRAF p.Asn486_Pro490del (NM_004333.6:c.1457_1471del15) causes increased colony formation (triplicates). Class 2 BRAF variant. PMID 26732095 · Chen et al., 2016 · Open in CIViC	civic
Unmapped disease1unmapped disease
BRAF Asn486_Pro490del	(functional)	Functional	D	Supports Gain Of Function	5	submitted	EID12994 BRAF p.Asn486_Pro490del (NM_004333.6:c.1457_1471del15) causes increased ratio of pERK/ERK. Class 2 BRAF variant. PMID 26732095 · Chen et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.