BRAF F247L

CI-VAR-00001097Explore in graph →CIViC 2802

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
BRAF F247L	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID7576 BRAF F247L led to modest activation of ERK signaling. This activation was abrogated by the R509 H mutation, indicating that this mutation requires dimerization to signal. Also, the absence of RAS expr… (full text at CIViC) PMID 31515458 · Yaeger et al., 2019 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.