Variant
BRAF L597
CI-VAR-00002367Explore in graph →CIViC 2766
Curated evidence
Evidence by cancer (4 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 30967421
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Malignant Colorectal Neoplasm1 | ||||||||
| BRAF L597 | (prognostic) | Prognostic | B | Supports Poor Outcome | 3 | submitted | EID7476Data from 117 patients with metastatic colorectal cancer (mCRC) harboring various BRAF mutations and 540 patients with mCRC harboring BRAF wild type were analyzed. BRAF mutation type was categorized t… (full text at CIViC) PMID 30967421 · Schirripa et al., 2019 · Open in CIViC | civic |
| Melanoma3 | ||||||||
| BRAF L597 | BRAF Inhibitor | Predictive | B | Does Not Support Sensitivity Response | 4 | submitted | EID7621In a retrospective study from 20 institutes in 4 countries, the efficacy of BRAF inhibitor and/or MEK inhibitor in patients with melanoma harboring BRAF nonV600E/K mutations were evaluated. Treated wi… (full text at CIViC) PMID 31580757 · | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available