Knowledge graph · Drug

Prednisone

small molecule

Identifier: CI-DRUG-00000488
Entity page: /drug/prednisone ↗
Edges: 1,090

Neighbours: 204 cancers1 genes10 trials1 approvals
Drawn: 60 of 216 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Prednisone approved for …APPROVED_FORderived1 of 1
→ approved for	FDA · US · 1972Prednisone tablets, USP are indicated in the following conditions: Endocrine Disorders Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance); congenital adrenal hyperplasia; hypercalcemia associated with cancer; nonsuppurative thyroiditis. Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: psoriatic arthritis, rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy), ankylosing spondylitis, acute and subacute bursitis, acute nonspecific tenosynovitis, acute gouty arthritis, post-traumatic osteoarthritis, synovitis of osteoarthritis, epicondylitis. Collagen Diseases During an exacerbation or as maintenance therapy in selected cases of: systemic lupus erythematosus, systemic dermatomyositis (polymyositis), acute rheumatic carditis. De rmatologic Diseases Pemphigus; bullous dermatitis herpetiformis; severe erythema multiforme (Stevens-Johnson syndrome); exfoliative dermatitis; mycosis fungoides; severe psoriasis; severe seborrheic dermatitis. Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment: seasonal or perennial allergic rhinitis; bronchial asthma; contact dermatitis; atopic dermatitis; serum sickness; drug hypersensitivity reactions. Ophthalmic Diseases Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as: allergic corneal marginal ulcers, herpes zoster ophthalmicus, anterior segment inflammation, diffuse posterior uveitis and choroiditis, sympathetic ophthalmia, allergic conjunctivitis, keratitis, chorioretinitis, optic neuritis, iritis and iridocyclitis. Respiratory Diseases Symptomatic sarcoidosis; Loeffler’s syndrome not manageable by other means; berylliosis; fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy; aspiration pneumonitis. Hematologic Disorders Idiopathic thrombocytopenic purpura in adults; secondary thrombocytopenia in adults; acquired (autoimmune) hemolytic anemia; erythroblastopenia (RBC anemia); congenital (erythroid) hypoplastic anemia. Neoplastic Diseases For palliative management of: leukemias and lymphomas in adults, acute leukemia of childhood. Edematous States To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus. Gastrointestinal Diseases To tide the patient over a critical period of the disease in: ulcerative colitis, regional enteritis. Miscellaneous Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy; trichinosis with neurologic or myocardial involvement.

Prednisone targets …TARGETS1 of 1
→ targets	NR3C1	—	AGONIST	—	1	Curated	chembl	graph →

Prednisone targets …TARGETS1 of 1

→ targets

NR3C1

—

AGONIST

—

Curated

Prednisone investigated for …INVESTIGATED_FOR15 of 49show all (up to 200)
→ investigated for	Brain Neoplasmsubtype	unknown	4	Brain Neoplasm	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Leukemiacancer_family	unknown	4	Leukemia	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	4	Lymphoma	1	Curated	chembl	graph →
→ investigated for	Mycosis Fungoideshematologic_malignancy	unknown	4	Mycosis Fungoides	1	Curated	chembl	graph →
→ investigated for	Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissuehematologic_malignancy	unknown	3	Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue	1	Curated	chembl	graph →
→ investigated for	Plasma Cell Neoplasmhematologic_malignancy	unknown	3	Plasma Cell Neoplasm	1	Curated	chembl	graph →
→ investigated for	Waldenstrom Macroglobulinemiahematologic_malignancy	unknown	3	Waldenstrom Macroglobulinemia	1	Curated	chembl	graph →
→ investigated for	Adult T-Cell Leukemia/Lymphomahematologic_malignancy	unknown	3	Adult T-Cell Leukemia/Lymphoma	1	Curated	chembl	graph →
→ investigated for	T Acute Lymphoblastic Leukemiahematologic_malignancy	unknown	3	T Acute Lymphoblastic Leukemia	1	Curated	chembl	graph →
→ investigated for	Breast Neoplasmcancer_family	unknown	3	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Central Nervous System Neoplasmcancer_family	unknown	3	Central Nervous System Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lymphoid Leukemiahematologic_malignancy	unknown	3	Lymphoid Leukemia	1	Curated	chembl	graph →
→ investigated for	Non-Hodgkin Lymphomahematologic_malignancy	unknown	3	Non-Hodgkin Lymphoma	1	Curated	chembl	graph →
→ investigated for	Sarcomacancer_family	unknown	3	Sarcoma	1	Curated	chembl	graph →

Prednisone studied in …STUDIED_INderived10 of 834show all (up to 200)
→ studied in	NCT00092222Phase 2 · active not recruiting Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity · 834 trials list this drug (214 active)	—	—	Malignant Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02257736Phase 3 · active not recruiting An Efficacy and Safety Study of Apalutamide (JNJ-56021927) in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone in Participants With Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer (mCRPC) · 834 trials list this drug (214 active)	—	—	Prostate Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT03223610Phase 1/Phase 2 · recruiting Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid (ViPOR) in Relapsed/Refractory B-cell Lymphoma · 834 trials list this drug (214 active)	—	—	Lymphoma,Non-Hodgkin Lymphoma,Burkitt Lymphoma+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT03431350Phase 2 · active not recruiting A Study of Niraparib Combination Therapies for the Treatment of Metastatic Castration-Resistant Prostate Cancer · 834 trials list this drug (214 active)	—	—	Prostate Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04497844Phase 3 · active not recruiting A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-MutatedProstatic Neoplasms (mCSPC) · 834 trials list this drug (214 active)	—	—	Prostate Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04662580Phase 1 · active not recruiting ARX517/JNJ-95298177 as Monotherapy or Combination Therapy in Subjects With Metastatic Prostate Cancer · 834 trials list this drug (214 active)	—	—	Malignant Prostate Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05600686Phase 2 · active not recruiting Loncastuximab Tesirine and Rituximab Followed by DA-EPOCH-R for Treating Patients With High-Risk Diffuse Large B-cell Lymphoma · 834 trials list this drug (214 active)	—	—	Double-Expressor Lymphoma,High Grade B-Cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements,High Grade B-Cell Lymphoma with MYC and BCL2 or BCL6 Rearrangements+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT06124157Phase 2 · recruiting A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL) · 834 trials list this drug (214 active)	—	—	B Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT02123758Phase 1 · active not recruiting A Study of JNJ-56021927 (ARN-509) and Abiraterone Acetate in Participants With Metastatic Castration-Resistant Prostate Cancer · 834 trials list this drug (214 active)	—	—	Prostate Neoplasm,Castration-Resistant Prostate Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03748641Phase 3 · active not recruiting A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer · 834 trials list this drug (214 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →

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