Hematologic Malignancy
Diffuse Large B-Cell Lymphoma Activated B-Cell Type
CI-CAN-00005108Explore in graph →
Hematologic6 active trials3 evidence items
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Hematologic Malignancy
CI-CAN-00005108Explore in graph →
Data completeness3 / 7 dimensions
Computed from entity_counters.completeness · refreshed after each connector run
Definition
A biologic subset of diffuse large B-cell lymphomas with a unique molecular signature or expression profile. It represents approximately 30% of diffuse large B-cell lymphomas, and is characterized by the expression of CD44, PKCbeta1, Cyclin D2, BCL-2, and IRF4/MUM1 genes. Morphologically, these lymphomas are either centroblastic or immunoblastic (ratio 2:1). Patients with this type of diffuse large B-cell lymphoma are reported to have a less favorable outcome compared to those with a germinal center B-cell expression profile, with a 5-year survival rate of 35% and a median survival of 2 years.
Data updated 22 days agoSource updated 26.08e
Taxonomy
Several hierarchies coexist; edges are listed per hierarchy type with their source.
Parents
Children (0)
Leaf node — no children.
Anatomy
Data updated 2 minutes agoSource updated unknowncounters aggregate over descendants
Names
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Key figures
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Data updated 2 minutes agoSource updated unknownregistry figures: cdc-uscs · latest year available per metric · counters aggregate over descendants