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Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma · CancerIndex

Cancers
Neoplasm
Neoplasm by Special Category
Malignant Neoplasm
Lymphoma
Non-Hodgkin Lymphoma
T-Cell Non-Hodgkin Lymphoma
Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

Hematologic Malignancy

Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

CI-CAN-00005967PTCLExplore in graph →

Hematologic172 active trials13 approved drugs9 evidence items

NCIt: C3468
DOID: 0050743

Overview
Statistics
Survival
Genomics1
Variants & evidence9
Drugs2
Trials786
Research
Rankings
Sources & provenance

Data completeness5 / 7 dimensions

Epidemiology (no data yet)
Survival (no data yet)
Trials (data present)
Literature (data present)
Genomics (data present)
Evidence (data present)
Therapies (data present)

Computed from entity_counters.completeness · refreshed after each connector run

Definition

What this entity is

This type of lymphoma is not frequently seen in the western hemisphere. Clinically, with the exception of anaplastic large cell lymphoma, mature T- and NK-cell lymphomas are among the most aggressive of all hematopoietic neoplasms. Representative disease entities include mycosis fungoides, angioimmunoblastic T-cell lymphoma, hepatosplenic T-cell lymphoma, and anaplastic large cell lymphoma.

Definition text as published by ncit-evsProvenance

Source: NCI Thesaurus (NCIt)
Dataset: NCI Thesaurus
Version: 26.08e
Retrieved: Sep 8, 2026
Layer: raw (as published)
Evidence: expert curation
License: CC BY 4.0
Run: ING-NCITEVS-20260908-000001

Open at source Curated

Data updated 22 days agoSource updated 26.08e

Taxonomy

Position in the hierarchies

Several hierarchies coexist; edges are listed per hierarchy type with their source.

Parents

ncit

Mature T-Cell and NK-Cell NeoplasmHematologic Malignancy
T-Cell Non-Hodgkin LymphomaHematologic Malignancy

Children (16)

ncit

Adult T-Cell Leukemia/Lymphoma7 sub
Anaplastic Large Cell Lymphoma19 sub
Childhood Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma4 sub
Follicular Helper T-Cell Lymphoma3 sub
Hepatosplenic T-Cell Lymphoma
Indolent T-Cell Non-Hodgkin Lymphoma3 sub
Intestinal T-Cell Lymphoma3 sub

Anatomy

Anatomical sites

Hematopoietic and Lymphatic SystemC35813

Record

Identity

CancerIndex ID: CI-CAN-00005967
Entity type: Hematologic Malignancy
Malignant: Yes
Solid / hematologic: Hematologic
Pediatric relevant: Not flagged
Rare cancer: Unknown (no incidence data yet)
Hierarchy depth: 6
Classification version: 26.08e
Semantic types: Neoplastic Process
Status: Active
Record updated: 2026-09-08

Coverage

Data completeness

Trials (all / active)

Mature T- and NK-Cell Lymphoma by Ann Arbor Stage5 sub

Methotrexate-Associated Peripheral T-Cell Lymphoma

Mycosis Fungoides and Sezary Syndrome4 sub

Nasal Type Extranodal NK/T-Cell Lymphoma7 sub

NK-Cell Lymphoma, Unclassifiable

Peripheral T-Cell Lymphoma, Not Otherwise Specified5 sub

Primary Central Nervous System Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma1 sub

Primary Cutaneous T-Cell Non-Hodgkin Lymphoma8 sub

Primary Nodal EBV-Positive T-Cell/NK-Cell Lymphoma

92 descendants in total; counters on this page aggregate over all of them.

786 / 172

Publications (all / 5y)

5,755 / 1,579

Evidence items

9

Genes / variants

5 / 5

Drugs (any / approved)

2 / 13

Genomic cohorts

1

Epidemiology / survival obs.

0 / 0

Data updated 18 hours agoSource updated unknowncounters aggregate over descendants

Names

Synonyms (8)

Mature T- and NK-Cell Lymphomassynonym · NCIt
Mature T-Cell and NK-Cell Lymphomasynonym · NCIt
Mature T-Cell and NK-Cell Non-Hodgkin's Lymphomasynonym · NCIt
mature T-cell lymphomasynonym · NCIt
Mature T-Cell Non-Hodgkin's Lymphomasynonym · NCIt
Mature T/NK-cell lymphomas, unspecified, unspecified sitesynonym · NCIt
NK- and T-cell lymphomasynonym · NCIt
Peripheral T-Cell Lymphomasynonym · NCIt

CancerIndex is a research and information platform. It does not diagnose and does not recommend treatment.

Key figures

At a glance

Each figure carries its unit, period and source; ranks link to "Why this rank?".

US deaths19,882countUnited States · 2024 · both sexes · all agescdc-wonderObservedrank #8 of 31 (USA · both sexes · all ages · 2024 · top-level cancers)figures shown for Non-Hodgkin Lymphoma (registry level) — open Non-Hodgkin Lymphoma
US new cases75,946countUnited States · 2023 · both sexes · all agescdc-uscsObservedrank #8 of 32 (USA · both sexes · all ages · 2023 · top-level cancers)figures shown for Non-Hodgkin Lymphoma (registry level) — open Non-Hodgkin Lymphoma
US age-standardized mortality4.5per 100,000United States · 2024 · both sexes · all ages · 2000 U.S. Std. Populationcdc-wonderObservedrank #7 of 23 (USA · both sexes · all ages · 2024 · top-level cancers)figures shown for Non-Hodgkin Lymphoma (registry level) — open Non-Hodgkin Lymphoma
Active trials172countcurrent registry status · entity + descendantsclinicaltrialsComputedrank #149 of 1,654 (World · both sexes · all ages · latest · all malignant entities)
Recruiting trials93countstatus RECRUITING · entity + descendantsclinicaltrialsComputedrank #146 of 1,277 (World · both sexes · all ages · latest · all malignant entities)
Curated evidence items9countaccepted CIViC items · entity + descendantscivicComputedrank #202 of 492 (World · both sexes · all ages · latest · all malignant entities)
Publications, last 12 months302countPubMed records · stored query · 12-month windowpubmedComputedrank #194 of 2,294 (World · both sexes · all ages · latest · all malignant entities)
Genomic cohorts1countopen GDC projects · entity + descendantsgdcComputedrank #228 of 296 (World · both sexes · all ages · latest · all malignant entities)

Data updated 18 hours agoSource updated unknownregistry figures: cdc-uscs · latest year available per metric · counters aggregate over descendants