Gene

PDGFRA

platelet derived growth factor receptor alpha

Explore in graph →CI-GENE-00019277HGNC:8803 ENSG00000134853 NCBI 5156 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (72)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 51–72 of 72 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PDGFRA K3852
(diagnostic)	Myxoid Glioneuronal TumorALIAS	Diagnostic	C	Supports Positive	3	submitted

Cohorts

Alteration frequency by cohort (126)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved126 cohort rows (showing 26, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Hepatocellular Carcinoma (MSK, JCO Precis Oncol 2023) hcc_jcopo_msk_2023	Hepatocellular Carcinoma	Ssm

Literature

Linked publications (20)

25 per page, newest first.

pubmedPublishedShowing 1–20 of 20 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.
· Blood · 2016 · PMID 27069254 · validated civic_curation pubmed
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor.
· J Clin Oncol · 2003 · PMID 14645423 · validated civic_curation pubmed
A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome.
· N Engl J Med · 2003 · PMID 12660384 · validated civic_curation pubmed
PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib.
· J Clin Oncol · 2005 · PMID 15928335 · validated

PDGFRA L579M1
Sunitinib	Gastrointestinal Stromal Tumor	Predictive	C	Supports Sensitivity Response	—	submitted	EID4575 In a retrospective study of 23 Taiwanese gastrointestinal stromal tumor patients, a patient with PDGFRA exon 18 mutation (n=1/21) was associated with partial response to sunitinib treatment. PMID 21547131 · Chen et al., 2011 · Open in CIViC	civic

PDGFRA L579M1

Sunitinib

Gastrointestinal Stromal Tumor

Predictive

Supports Sensitivity Response

—

submitted

EID4575

In a retrospective study of 23 Taiwanese gastrointestinal stromal tumor patients, a patient with PDGFRA exon 18 mutation (n=1/21) was associated with partial response to sunitinib treatment.

PMID 21547131 · Chen et al., 2011 · Open in CIViC

PDGFRA Mutation4
Imatinib	Gastrointestinal Stromal Tumor	Predictive	B	Supports Sensitivity Response	1	submitted	EID11331 In this retrospective survey among referral centers and collaborative groups with experience in conducting clinical studies in sarcoma and/or GISTs in Europe, 58 patients were included with advanced P… (full text at CIViC) PMID 22718859 · Cassier et al., 2012 · Open in CIViC	civic
〃	Gastrointestinal Stromal Tumor	Predictive	C	Supports Sensitivity Response	3	accepted	EID2487 This prospective study of 127 patients with metastatic gastrointestinal stromal tumors (GISTs) examined the relationship between kinase (KIT and PDGFRA) genotype and treatment outcome for patients enr… (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC	civic
Regorafenib Anhydrous	Gastrointestinal Stromal Tumor	Predictive	A	Supports Sensitivity Response	4	rejected	EID11332 In this phase III trial, 240 patients with histologically confirmed, metastatic or unresectable GIST, with failure of at least previous imatinib and sunitinib were randomized in 2:1 to receive either … (full text at CIViC) PMID 23177515 · Demetri et al., 2013 · Open in CIViC	civic
Ripretinib	Gastrointestinal Stromal Tumor	Predictive	A	Supports Sensitivity Response	4	submitted	EID11333 In this phase III trial, 154 assessed patients with advanced gastrointestinal stromal tumours with progression on at least imatinib, sunitinib, and regorafenib or documented intolerance to any of thes… (full text at CIViC) PMID 32511981 · Blay et al., 2020 · Open in CIViC	civic

PDGFRA Overexpression2
Dasatinib	High-Grade Glioma, NOS	Predictive	D	Supports Sensitivity Response	3	submitted	EID7934 Tumor cell line generated from pediatric high-grade glioma patient was found to have amplification of PDGFRA and FGF2. Gene expression of PDGFRA and FGF2 was found to be in the 99th percentile compare… (full text at CIViC) PMID 27582545 · Koschmann et al., 2016 · Open in CIViC	civic
Sunitinib	Rhabdomyosarcoma	Predictive	D	Supports Sensitivity Response	3	accepted	EID7988 A high-throughput screen of 637 cancer cell lines revealed 2 to be sensitive to the multiple tyrosine kinase inhibitor, sunitinib. The most highly sensitive line was A-204, a rhabdomyosarcoma cell lin… (full text at CIViC) PMID 19366796 · McDermott et al., 2009 · Open in CIViC	civic

PDGFRA V658A2
Crenolanib	Melanoma	Predictive	D	Supports Sensitivity Response	3	submitted	EID8890 PDGFRA mutations (exon 12, 14, 18) were assessed in 351 melanoma patient samples. 18 different mutations were detected in 4.6% of samples (all without chronic sun-induced damage and mainly in acral an… (full text at CIViC) PMID 24132921 · Dai et al., 2013 · Open in CIViC	civic
Imatinib	Melanoma	Predictive	D	Supports Resistance	3	submitted	EID8889 PDGFRA mutations (exon 12, 14, 18) were assessed in 351 melanoma patient samples. 18 different mutations were detected in 4.6% of samples (all without chronic sun-induced damage and mainly in acral an… (full text at CIViC) PMID 24132921 · Dai et al., 2013 · Open in CIViC	civic

PDGFRA Fusion2
(diagnostic)	Chronic Myelomonocytic Leukemia	Diagnostic	A	Supports Negative	5	accepted	EID1425 The 2016 World Health Organization guidelines for the classification of myeloid malignancies uses the detection of PCM1-JAK2 or rearrangements involving PDGFRA, PDGFRB, or FGFR1 as recommended exclusi… (full text at CIViC) PMID 27069254 · Arber et al., 2016 · Open in CIViC	civic
〃	Myeloid/Lymphoid Neoplasms with Eosinophilia and Tyrosine Kinase Gene FusionsALIAS	Diagnostic	A	Supports Positive	5	accepted	EID1433 The 2016 World Health Organization guidelines for the classification of myeloid malignancies and acute leukemia describes a new class of disease defined by myeloid or lymphoid neoplasms associated wit… (full text at CIViC) PMID 27069254 · Arber et al., 2016 · Open in CIViC	civic