PDGFRA V561D

CI-VAR-00004558Explore in graph →NP_006197.1:p.Val561AspNM_006206.5:c.1682T>AClinVar 13546 CIViC 941 rs121908586

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Gastrointestinal Stromal Tumor1
PDGFRA V561D	Imatinib	Predictive	C	Supports Sensitivity Response	1	accepted	EID2474 This case study examines one patient from a larger cohort of 397 patients with incurable (i.e. metastatic or unresectable) CD117-positive Gastrointestinal stromal tumors (GISTs) enrolled in the North … (full text at CIViC) PMID 18955451 · Heinrich et al., 2008 · Open in CIViC	civic
Malignant Neoplasm3
PDGFRA V561D	Imatinib	Predictive	D	Does Not Support Resistance	2	accepted	EID2454 In an in vitro study of imatinib sensitivity, PDGFRA V561D was cloned into a plasmid by site-directed mutagenesis of PDGFRA WT cDNA. Chinese hamster ovary cells were transiently transfected with the p… (full text at CIViC) PMID 14645423 ·

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
13546	Conflicting classifications of pathogenicity	no assertion criteria provided	0	Gastrointestinal stromal tumor; Polyps, multiple and recurrent inflammatory fibroid, gastrointestinal; Diffuse midline glioma, H3 K27M-mutant	somatic	4	Sep 01, 2007	clinvar