Publication
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (20)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 20
- cancerGastrointestinal Stromal Tumorcivic_curation1.00
- cancerMalignant Neoplasmcivic_curation1.00
- drugImatinibcivic_curation1.00
- geneKITcivic_curation1.00
- genePDGFRAcivic_curation1.00
- variantKIT D816Vcivic_curation1.00
- variantKIT Exon 11 Mutationcivic_curation1.00
- variantKIT Exon 13 Mutationcivic_curation1.00
- variantKIT Exon 9 Mutationcivic_curation1.00
- variantKIT K642Ecivic_curation1.00
- variantKIT N822Hcivic_curation1.00
- variantKIT N822Kcivic_curation1.00
- variantKIT V560Gcivic_curation1.00
- variantKIT W557_K558delcivic_curation1.00
- variantKIT Y503_F504insAYcivic_curation1.00
- variantPDGFRA D842_H845DELDIMHcivic_curation1.00
- variantPDGFRA D842Vcivic_curation1.00
- variantPDGFRA I843DELcivic_curation1.00
- variantPDGFRA Mutationcivic_curation1.00
- variantPDGFRA V561Dcivic_curation1.00
Curated evidence
Evidence citing this paper (18)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 14645423
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| KIT Exon 11 Mutation3 | ||||||||
| (prognostic) | Gastrointestinal Stromal Tumor | Prognostic | B | Supports Better Outcome | 4 | rejected | EID653Patients with Exon 11 Kit mutations (N=85) had significantly better event-free and overall survival than patients with Exon 9 Kit mutations (N=23) or no Kit mutations (N=9). PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | A | Supports Sensitivity Response | 4 | accepted | EID654This prospective study of 127 pretreatment patients with metastatic gastrointestinal stromal tumors (GISTs) examined the relationship between kinase (KIT and PDGFRA) genotype and treatment outcome for… (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |
| 〃 | Gastrointestinal Stromal Tumor | Predictive | E | Supports Sensitivity Response | 2 | submitted | civic | |
| KIT Exon 13 Mutation1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | C | Supports Sensitivity Response | 2 | accepted | EID2475This prospective study of 127 patients with metastatic gastrointestinal stromal tumors (GISTs) examined the relationship between kinase (KIT and PDGFRA) genotype and treatment outcome for patients enr… (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |
| KIT Exon 9 Mutation1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | B | Supports Sensitivity Response | 3 | accepted | EID2466This prospective study of 127 patients with metastatic gastrointestinal stromal tumors (GISTs) examined the relationship between KIT genotype and treatment outcome for patients enrolled in a randomize… (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |
| PDGFRA D842V2 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | C | Supports Resistance | 2 | accepted | EID2478This prospective study of 127 patients with metastatic gastrointestinal stromal tumors (GISTs) examined the relationship between kinase (KIT and PDGFRA) genotype and treatment outcome for patients enr… (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |
| 〃 | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 2 | accepted | EID2463In an in vitro study of imatinib sensitivity, PDGFRA D842V was cloned into a plasmid by site-directed mutagenesis of PDGFRA WT cDNA. Chinese hamster ovary cells were transiently transfected with the p… (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |
| PDGFRA I843DEL1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID130915/127 patients with KIT-WT metastatic gastrointestinal stromal tumors were tested for PDGFRA mutations. 6 GISTs harbored PDGFRA mutations. 1 patient had a deletion of I843. CHO cells expressing this … (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |
| PDGFRA Mutation1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | C | Supports Sensitivity Response | 3 | accepted | EID2487This prospective study of 127 patients with metastatic gastrointestinal stromal tumors (GISTs) examined the relationship between kinase (KIT and PDGFRA) genotype and treatment outcome for patients enr… (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |
| KIT D816V1 | ||||||||
| Imatinib | Malignant NeoplasmALIAS | Predictive | D | Supports Resistance | 2 | accepted | EID2451In an in vitro study of imatinib sensitivity, KIT D816V was cloned into a plasmid by site-directed mutagenesis of KIT WT cDNA. Chinese hamster ovary cells were transiently transfected with the plasmid… (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |
| KIT K642E1 | ||||||||
| Imatinib | Malignant NeoplasmALIAS | Predictive | D | Does Not Support Resistance | 2 | accepted | EID2472In an in vitro study of imatinib sensitivity, KIT K642E was cloned into a plasmid by site-directed mutagenesis of KIT WT cDNA. Chinese hamster ovary cells were transiently transfected with the plasmid… (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |
| KIT N822H1 | ||||||||
| Imatinib | Malignant NeoplasmALIAS | Predictive | D | Does Not Support Resistance | 2 | accepted | EID2445In an in vitro study of imatinib sensitivity, KIT N822H was cloned into a plasmid by site-directed mutagenesis of KIT WT cDNA. Chinese hamster ovary cells were transiently transfected with the plasmid… (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |
| KIT N822K1 | ||||||||
| Imatinib | Malignant NeoplasmALIAS | Predictive | D | Does Not Support Sensitivity Response | 2 | accepted | EID2448In an in vitro study of imatinib sensitivity, KIT N822K was cloned into a plasmid by site-directed mutagenesis of KIT WT cDNA. Chinese hamster ovary cells were transiently transfected with the plasmid… (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |
| KIT V560G1 | ||||||||
| Imatinib | Malignant NeoplasmALIAS | Predictive | D | Does Not Support Resistance | 2 | accepted | EID2469In an in vitro study of imatinib sensitivity, KIT V560G was cloned into a plasmid by site-directed mutagenesis of KIT WT cDNA. Chinese hamster ovary cells were transiently transfected with the plasmid… (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |
| KIT W557_K558del1 | ||||||||
| Imatinib | Malignant NeoplasmALIAS | Predictive | D | Does Not Support Resistance | 2 | accepted | EID2481In an in vitro study of imatinib sensitivity, KIT W557_K558del was cloned into a plasmid by site-directed mutagenesis of KIT WT cDNA. Chinese hamster ovary cells were transiently transfected with the … (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |
| KIT Y503_F504insAY1 | ||||||||
| Imatinib | Malignant NeoplasmALIAS | Predictive | D | Does Not Support Resistance | 2 | accepted | EID2484In an in vitro study of imatinib sensitivity, KIT Y503_F504insAY was cloned into a plasmid by site-directed mutagenesis of KIT WT cDNA. Chinese hamster ovary cells were transiently transfected with th… (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |
| PDGFRA D842_H845DELDIMH1 | ||||||||
| Imatinib | Malignant NeoplasmALIAS | Predictive | D | Does Not Support Resistance | 2 | accepted | EID2460In an in vitro study of imatinib sensitivity, PDGFRA D842_H845del was cloned into a plasmid by site-directed mutagenesis of PDGFRA WT cDNA. Chinese hamster ovary cells were transiently transfected wit… (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |
| PDGFRA V561D1 | ||||||||
| Imatinib | Malignant NeoplasmALIAS | Predictive | D | Does Not Support Resistance | 2 | accepted | EID2454In an in vitro study of imatinib sensitivity, PDGFRA V561D was cloned into a plasmid by site-directed mutagenesis of PDGFRA WT cDNA. Chinese hamster ovary cells were transiently transfected with the p… (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC | civic |