Publication
Molecular correlates of imatinib resistance in gastrointestinal stromal tumors.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (13)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 13
- cancerGastrointestinal Stromal Tumorcivic_curation1.00
- drugImatinibcivic_curation1.00
- geneKITcivic_curation1.00
- genePDGFRAcivic_curation1.00
- variantKIT C809Gcivic_curation1.00
- variantKIT D816Hcivic_curation1.00
- variantKIT D820Acivic_curation1.00
- variantKIT D820Gcivic_curation1.00
- variantKIT N822Kcivic_curation1.00
- variantKIT T670Icivic_curation1.00
- variantKIT V654Acivic_curation1.00
- variantKIT Y823Dcivic_curation1.00
- variantPDGFRA D842Vcivic_curation1.00
Curated evidence
Evidence citing this paper (9)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 16954519
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| KIT C809G1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | C | Supports Resistance | 3 | accepted | EID2920147 patients with advanced, unresectable GISTs were enrolled onto a randomized, phase II clinical study of imatinib (CSTI571-B2222). Specimens from 43 pretreatment and/or imatinib-resistant tumors wer… (full text at CIViC) PMID 16954519 · Heinrich et al., 2006 · Open in CIViC | civic |
| KIT D816H1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | C | Supports Resistance | 3 | accepted | EID2923147 patients with advanced, unresectable GISTs were enrolled onto a randomized, phase II clinical study of imatinib (CSTI571-B2222). Specimens from 43 pretreatment and/or imatinib-resistant tumors wer… (full text at CIViC) PMID 16954519 · Heinrich et al., 2006 · Open in CIViC | civic |
| KIT D820A1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | C | Supports Resistance | 3 | accepted | EID2921147 patients with advanced, unresectable GISTs were enrolled onto a randomized, phase II clinical study of imatinib (CSTI571-B2222). Specimens from 43 pretreatment and/or imatinib-resistant tumors wer… (full text at CIViC) PMID 16954519 · Heinrich et al., 2006 · Open in CIViC | civic |
| KIT D820G1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | C | Supports Resistance | 3 | accepted | EID2922147 patients with advanced, unresectable GISTs were enrolled onto a randomized, phase II clinical study of imatinib (CSTI571-B2222). Specimens from 43 pretreatment and/or imatinib-resistant tumors wer… (full text at CIViC) PMID 16954519 · Heinrich et al., 2006 · Open in CIViC | civic |
| KIT N822K1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | C | Supports Resistance | 3 | accepted | EID2918147 patients with advanced, unresectable GISTs were enrolled onto a randomized, phase II clinical study of imatinib (CSTI571-B2222). Specimens from 43 pretreatment and/or imatinib-resistant tumors wer… (full text at CIViC) PMID 16954519 · Heinrich et al., 2006 · Open in CIViC | civic |
| KIT T670I1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | C | Supports Resistance | 3 | accepted | EID2924147 patients with advanced, unresectable GISTs were enrolled onto a randomized, phase II clinical study of imatinib (CSTI571-B2222). Specimens from 43 pretreatment and/or imatinib-resistant tumors wer… (full text at CIViC) PMID 16954519 · Heinrich et al., 2006 · Open in CIViC | civic |
| KIT V654A1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | D | Supports Resistance | 3 | accepted | EID249KIT V654A results in imatinib resistance in GIST patient-derived cell lines. PMID 16954519 · Heinrich et al., 2006 · Open in CIViC | civic |
| KIT Y823D1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | C | Supports Resistance | 3 | accepted | EID2919147 patients with advanced, unresectable GISTs were enrolled onto a randomized, phase II clinical study of imatinib (CSTI571-B2222). Specimens from 43 pretreatment and/or imatinib-resistant tumors wer… (full text at CIViC) PMID 16954519 · Heinrich et al., 2006 · Open in CIViC | civic |
| PDGFRA D842V1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | B | Supports Resistance | 4 | accepted | EID16While cancer with PDGFRA V561D mutation is known to be sensitive to Imatinib, double mutation of V561D and D842V mutants are resistant to imatinib. PMID 16954519 · Heinrich et al., 2006 · Open in CIViC | civic |