PDGFRA L579M

CI-VAR-00002364Explore in graph →ENST00000257290.5:c.2455C>ACIViC 1540

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Gastrointestinal Stromal Tumor1
PDGFRA L579M	Sunitinib	Predictive	C	Supports Sensitivity Response	—	submitted	EID4575 In a retrospective study of 23 Taiwanese gastrointestinal stromal tumor patients, a patient with PDGFRA exon 18 mutation (n=1/21) was associated with partial response to sunitinib treatment. PMID 21547131 · Chen et al., 2011 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.