Hematologic Malignancy
B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like
CI-CAN-00004540Explore in graph →
Hematologic3 active trials80 evidence items
- NCIt
- C129787
- OncoTree
- BLLBCRABL1L
- DOID
- 0080650
- UMLS CUI
- C4329382
Loading cancer entity…
Loading cancer entity…
Hematologic Malignancy
CI-CAN-00004540Explore in graph →
Variants & evidence
128 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.
| Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|
| ABL1 Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 3 | accepted | EID9160A 34-year-old woman was hospitalized because of weakness and mild fever. Physical examination revealed multiple and superficial lymph nodes. Peripheral blood counting showed a 47% blasts. Bone marrow … (full text at CIViC) PMID 27894117 · Sheng et al., 2017 · Open in CIViC | civic |
| PDGFRB e6::e112 | |||||||
| (oncogenic) | Oncogenic | C | Supports Oncogenicity | 4 | submitted | EID13007A 4 yr old boy was diagnosed with precursor B-cell ALL. Patient had normal karyotype. The patient was refractory to prolonged induction therapy. Presence of PDGFRB rearrangement was indicated by F… (full text at CIViC) PMID 29434033 · Zhang et al., 2018 · Open in CIViC | civic |
| Imatinib | Predictive | C | Supports Sensitivity Response | 4 | submitted | EID13008A 4 yr old boy with AGGF1::PDGFRB Fusion, and Ph-Like B-ALL was refractory to chemotherapy and did not respond to induction therapy. The patient was given imatinib, and within 8 weeks leukemia clearan… (full text at CIViC) PMID 29434033 · Zhang et al., 2018 · Open in CIViC | civic |
| PDGFRB Fusion + PDGFRB C843G1 | |||||||
| CHZ868 | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID6999A 4 year old boy with normal karyotype relapsed, refractory B-cell ALL had initial but not sustained response to TKIs including imatinib, dasatinib and nilotinib, followed by a bone marrow transplant.… (full text at CIViC) PMID 29434033 · Zhang et al., 2018 · Open in CIViC | civic |
| JAK2 Fusion2 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 3 | accepted | EID7671In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 3 | accepted | EID8095In B-lymphoblastic leukemia/lymphoma (B-ALL), the presence of this fusion is associated with so-called BCR/ABL1 like (Ph-like) subtype of the disease. The ATF7IP-JAK2 fusion is rare; in this study inv… (full text at CIViC) PMID 27870571 · Roberts et al., 2017 · Open in CIViC | civic |
| JAK2 Fusion4 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 4 | accepted | EID7698In this study which included 1389 cases of high-risk pediatric B-ALL, 284 were identified by TaqMan Low Density Array to have a Ph-like gene expression signature. RT-PCR or RNAseq performed on the 129… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 4 | accepted | EID8101In this study involving 574 pediatric B-ALL patients (from a Dutch/German cohort), 77 were shown to be Ph-like cases identified by hierarchical clustering of gene expression data. In one male patient … (full text at CIViC) PMID 27894077 · Boer et al., 2017 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 3 | accepted | EID7697In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … | |
| PDGFRA Fusion1 | |||||||
| Chemotherapy + ImatinibCombination | Predictive | C | Supports Sensitivity Response | 2 | submitted | EID12582A 39-year-old Chinese man was hospitalized in May 2021 with concerns of thirst and weight loss. Immature B lymphocytes were detected in blood (83.8%) and bone marrow (87%) and FISH showed the absence … (full text at CIViC) PMID 41143846 · Hua et al., 2024 · Open in CIViC | civic |
| ABL1 Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 2 | accepted | EID9078This study included 1389 cases of high-risk pediatric B-ALL, of which 284 were identified by TaqMan Low Density Array to have a BCR-ABL1-like (Ph-like) gene expression signature. RT-PCR or RNAseq perf… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC | civic |
| ABL1 Fusion1 | |||||||
| (oncogenic) | Oncogenic | C | Supports Oncogenicity | 2 | submitted | EID13001In a 56-year-old female diagnosed with B-lymphoblastic leukemia/lymphoma (B-ALL), transcriptome sequencing (RNA-seq) identified a CNTRL::ABL1 fusion. At diagnosis, the patient had a white blood cell c… (full text at CIViC) PMID 37103615 · Tan et al., 2023 · Open in CIViC | civic |
| JAK2 Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 3 | accepted | EID7672In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| PDGFRB Fusion6 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 3 | submitted | EID11625B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 3 patients (ages 6, 14.4, and 19.… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| Imatinib | Predictive | C | Supports Sensitivity Response | 3 | accepted | EID1310A 10-year-old boy with B-cell acute lymphoblastic leukemia refractory to conventional chemotherapy and harboring an EBF1-PDGFRB fusion responded to imatinib plus induction chemotherapy (vincristine, d… (full text at CIViC) PMID 23835704 · Weston et al., 2013 · Open in CIViC | civic |
| 〃 | Predictive | C | Supports Sensitivity Response | 2 | submitted | EID7127EBF1-PDGFRB fusion was detected in leukemia cells of a 6 year old male who presented with B-ALL and an initial WBC of 244,400. He received 4-drug induction chemotherapy but failed to enter remission w… | |
| EPOR Overexpression1 | |||||||
| (diagnostic) | Diagnostic | A | Supports Positive | 3 | submitted | EID7023The study showed that the EPOR gene rearrangements with immunoglobulin loci are associated with Ph-like molecular subtype of B-ALL, characterized by a gene-expression profile similar to that of the BC… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| EPOR rearrangements1 | |||||||
| (diagnostic) | Diagnostic | B | Supports Positive | 4 | accepted | EID12397This 2017 study is result of collaboration of multiple institutions and was led by St. Jude Children's Research Hospital team. The total cohort of 3115 B-ALL patients (all ages) was studied, with 212 … (full text at CIViC) PMID 26859458 · Iacobucci et al., 2016 · Open in CIViC | civic |
| ABL1 Fusion2 | |||||||
| (diagnostic) | Diagnostic | B | Supports Positive | 4 | accepted | EID9073This study determined the incidence, clinical characteristics and associated genetic abnormalities in hematologic malignancies with the ETV6-ABL1 fusion. The total of 44 new and previously published E… (full text at CIViC) PMID 27229714 · Zaliova et al., 2016 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 2 | submitted | EID11614B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 2 of 2 patients (ages 5 and 82 ye… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| JAK2 Fusion3 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 4 | accepted | EID8102In this study which included 1389 cases of high-risk pediatric B-ALL, 284 were identified by TaqMan Low Density Array to have a Ph-like gene expression signature. RT-PCR or RNAseq performed on CRLF2 n… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 3 | accepted | EID7696In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 3 | accepted | EID8097In B-lymphoblastic leukemia/lymphoma (B-ALL), the presence of this fusion is associated with so-called BCR/ABL1 like (Ph-like) subtype of the disease. In this study involving 798 B-ALL patients of whi… | |
| NTRK3 Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 1 | submitted | EID12295Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk subtype characterised by genomic alterations that activate cytokine receptor and kinase signaling. The author e… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC | civic |
| PDGFRA Fusion2 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 3 | submitted | EID13331In a 10-year-old female diagnosed with B-lymphoblastic leukemia/lymphoma (B-LL/B-ALL), FISH analysis identified a CHIC2 deletion, suggestive of a FIP1L1::PDGFRA fusion, which was subsequently confirme… (full text at CIViC) PMID 39996417 · Nunn et al., 2025 · Open in CIViC | civic |
| Chemotherapy + ImatinibCombination | Predictive | C | Supports Sensitivity Response | 2 | submitted | EID12565A 10‐year‐old female patient presented with pancytopenia and normal eosinophils and had the diagnosis of B‐lymphoblastic leukemia/lymphoma. FISH identified a CHIC2 deletion, suggestive of FIP1L1::PDG… (full text at CIViC) PMID 39996417 · Nunn et al., 2025 · Open in CIViC | civic |
| ABL1 Fusion4 | |||||||
| (oncogenic) | Oncogenic | C | Supports Oncogenicity | 2 | accepted | EID7253In a 16-year old Caucasian female with B-lymphoblastic leukemia (B-ALL), the t(3;9)(p12;q34) was identified by cytogenetic studies. 5'RACE PCR detected the in-frame FOXP1::ABL1 (exon 19::exon 4) fusio… (full text at CIViC) PMID 21391972 · Ernst et al., 2011 · Open in CIViC | civic |
| (prognostic) | Prognostic | C | Supports Poor Outcome | 1 | accepted | EID7651The FOXP1::ABL1 fusion was identified in a male patient in a Dutch/German cohort of 77 BCR::ABL1-like cases. The FOXP1::ABL1 fusion was confirmed by PCR and targeted ligation amplification, and was fo… (full text at CIViC) PMID 27894077 · Boer et al., 2017 · Open in CIViC | civic |
| (diagnostic) | Diagnostic | C | Supports Positive | 1 | accepted | EID11615B-lymphoblastic leukemia/lymphoma (B-ALL) cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine BCR::ABL1-like… (full text at CIViC) | |
| KIT Fusion1 | |||||||
| (oncogenic) | Oncogenic | D | Supports Oncogenicity | 4 | submitted | EID10172A 52-year-old Caucasian male with second relapsed B-ALL following chemotherapy and blinatumomab (NCT02013167). BMA obtained at study entry on the INOVATE trial (NCT01564784) was analyzed by RNA-seq an… (full text at CIViC) PMID 34991158 · Iacobucci et al., 2022 · Open in CIViC | civic |
| JAK2 Fusion1 | |||||||
| Ruxolitinib | Predictive | C | Supports Sensitivity Response | 3 | accepted | EID7007A 10-year-old Caucasian boy with high risk B-cell acute lymphoblastic leukemia failed induction therapy. The patient had a complex karyotype and microarray revealed a 9p duplication involving JAK2 and… (full text at CIViC) PMID 29773603 · Ding et al., 2018 · Open in CIViC | civic |
| CRLF2 Fusion3 | |||||||
| (diagnostic) | Diagnostic | B | Supports Positive | 5 | accepted | EID11613The authors performed genomic profiling of 1725 cases of B-lymphoblastic leukemia/lymphoma (B-ALL). Overall, 264 of 1725 B-ALL cases (15.3%) were identified as BCR::ABL1 (Ph)-like based on their expr… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 4 | accepted | EID8233Among 284 cases with Ph-like expression signature who were identified by testing 1389 high-risk cases of pediatric B-ALL, overexpression and rearrangement of CRLF2 were identified in 124 (43.7%). This… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 2 | accepted | EID11621B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 2 patients (ages 7.6 and 16.3 yea… | |
| EPOR Fusion4 | |||||||
| (diagnostic) | Diagnostic | B | Supports Positive | 4 | accepted | EID12395This MD Anderson Cancer Center study describes six adult patients (3 males and 3 females, median age 39 yo) with t(14;19)(q32;p13) resulting in IGH::EPOR. 3 patients did not receive any prior chemothe… (full text at CIViC) PMID 24030742 · Jaso et al., 2014 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 4 | accepted | EID12393In this 2024 case report the authors describe a case of BCR::ABL1-like B-ALL with unusual granular morphology in a female patient, 12 year old, with the following symptoms: paroxysmal headache, vomiti… (full text at CIViC) PMID 38302862 · Long et al., 2024 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 4 | accepted | EID12394This is a case report from MD Anderson Cancer Center. A 40yo Caucasian male patient was diagnosed with B-ALL with IGH::EPOR fusion. The patient received 4 cycles of R-hyper-CVAD and archived CR with M… | |
| IL7R S185C1 | |||||||
| (oncogenic) | Oncogenic | C | Supports Oncogenicity | 4 | submitted | EID6226The manuscript shows that somatic gain-of-function mutations in IL7R occur in the cases of pediatric B-lymphoblastic leukemias characterized by aberrant expression of cytokine receptor-like factor 2 (… (full text at CIViC) PMID 21536738 · Shochat et al., 2011 · Open in CIViC | civic |
| JAK1 S646F1 | |||||||
| Ruxolitinib | Predictive | D | Supports Sensitivity Response | 2 | submitted | EID7957A patient derived Ph-like B-ALL Xenograft (V) harboring the JAK1 S646F mutation was treated with ruxolitinib. Compared to vehicle, the ruxolitinib treated Xenograft had lower peripheral and splenic b… (full text at CIViC) PMID 22955920 · Maude et al., 2012 · Open in CIViC | civic |
| ABL1 Fusion2 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 2 | accepted | EID9080This retrospective study included 1389 cases of high-risk pediatric B-ALL, of which 284 were identified by TaqMan Low Density Array to have a BCR-ABL1-like (Ph-like) gene expression signature. RT-PCR … (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC | civic |
| (prognostic) | Prognostic | C | Supports Poor Outcome | 2 | accepted | EID9153This retrospective study reported the outcome of 24 patients with Ph-like acute lymphoblastic leukemia (Ph-like ALL) harboring ABL-class fusions who were treated with a combination of tyrosine kinase … (full text at CIViC) PMID 31434701 · Tanasi et al., 2019 · Open in CIViC | civic |
| CSF1R Fusion1 | |||||||
| Imatinib | Predictive | C | Supports Sensitivity Response | 3 | accepted | EID9360This study describes a cohort of 24 patients with BCR-ABL1-like B-ALL and ABL-class kinase rearrangement exposed to TKI frontline or at relapse, who showed favorable MRD response and outcome. Specific… (full text at CIViC) PMID 31434701 · Tanasi et al., 2019 · Open in CIViC | civic |
| TYK2 Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 3 | accepted | EID12810In this 2014 genomic profiling study of 1,725 patients with precursor B-cell acute lymphoblastic leukemia (B-ALL), the authors define the high-risk "Philadelphia chromosome-like" (Ph-like or BCR::ABL1… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| ABL1 Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 2 | accepted | EID9079This study included 1389 cases of high-risk pediatric B-ALL, of which 284 were identified by TaqMan Low Density Array to have a BCR-ABL1-like (Ph-like) gene expression signature. RT-PCR or RNAseq perf… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC | civic |
Data updated 21 hours agoSource updated unknownsource: civic (CC0)
Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.
PMID 25207766 · Roberts et al., 2014 · Open in CIViC
| civic |
| 〃 | Diagnostic | C | Supports Positive | 3 | accepted | EID8096In B-lymphoblastic leukemia/lymphoma (B-ALL), the presence of this fusion is associated with so-called BCR/ABL1 like (Ph-like) subtype of the disease. In this study involving 798 B-ALL patients of whi… (full text at CIViC) PMID 27870571 · Roberts et al., 2017 · Open in CIViC | civic |
PMID 25207766 · Roberts et al., 2014 · Open in CIViC
| civic |
| 〃 | Predictive | D | Supports Sensitivity Response | 3 | submitted | EID12644In a group of 73 of Dutch and German children with Ph-Like B Cell Precursor ALL, 12 tyrosine kinase-activating fusion genes were found. 4 of the Fusions were EBF1::PDGFRB. Leukemic cells taken from t… (full text at CIViC) | civic |
| Chemotherapy + ImatinibCombination | Predictive | C | Supports Sensitivity Response | 3 | accepted | EID8260A 9 year old girl with B-lymphoblastic leukemia/ lymphoma (2016 WHO) relapsed 15 months post-maintenance chemotherapy. FISH and genomic analysis detected the EBF1-PDGFRB fusion (exon 11 with Exon14). … (full text at CIViC) PMID 32068648 · Sakurai et al., 2021 · Open in CIViC | civic |
| Dasatinib + ImatinibSubstitutes | Predictive | C | Supports Sensitivity Response | 2 | accepted | EID7128The EBF1-PDGFRB fusion was detected in leukemia cells of a 7 year old Latino boy who presented with B-ALL and initial WBC of 600,000. He failed to enter remission with 4 drug induction (90% blasts at … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
PMID 27870571 · Roberts et al., 2017 · Open in CIViC
| civic |
PMID 25207766 · Roberts et al., 2014 · Open in CIViC
| civic |
| Dasatinib | Predictive | C | Supports Sensitivity Response | 1 | accepted | EID7292A 16-year-old Caucasian boy was diagnosed with B-lymphoblastic leukemia (B-ALL). Karyotype showed an abnormal clone characterized by the t(3;9)(p13;q34.1). This translocation has been shown previously… (full text at CIViC) PMID 30938769 · Yenamandra et al., 2019 · Open in CIViC | civic |
PMID 25207766 · Roberts et al., 2014 · Open in CIViC
| civic |
PMID 32330662 · Liu et al., 2020 · Open in CIViC
| civic |
| 〃 | Diagnostic | C | Supports Positive | 4 | accepted | EID12396This 2021 study reports 3 adolescent/young adult patients with IGH::EPOR-positive B-ALL treated with post-induction chemotherapy combined with JAKi ruxolitinib or TKI ponatinib. Patient 1 was hispanic… (full text at CIViC) PMID 34196168 · Niswander et al., 2021 · Open in CIViC | civic |