Publication
Large-scale analysis of PDGFRA mutations in melanomas and evaluation of their sensitivity to tyrosine kinase inhibitors imatinib and crenolanib.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (8)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 8
- cancerMelanomacivic_curation1.00
- drugCrenolanibcivic_curation1.00
- drugImatinibcivic_curation1.00
- genePDGFRAcivic_curation1.00
- variantPDGFRA G853Dcivic_curation1.00
- variantPDGFRA H845Ycivic_curation1.00
- variantPDGFRA P577Scivic_curation1.00
- variantPDGFRA R841Kcivic_curation1.00
Curated evidence
Evidence citing this paper (6)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24132921
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PDGFRA G853D1 | ||||||||
| Crenolanib + ImatinibSubstitutes | Melanoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1977PDGFRA mutations (exon 12, 14, 18) were assessed in 351 melanoma patient samples. 18 different mutations were detected in 4,6% of samples (all without chronic sun-induced damage and mainly in acral an… (full text at CIViC) PMID 24132921 · Dai et al., 2013 · Open in CIViC | civic |
| PDGFRA H845Y1 | ||||||||
| Crenolanib + ImatinibSubstitutes | Melanoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1976PDGFRA mutations (exon 12, 14, 18) were assessed in 351 melanoma patient samples. 18 different mutations were detected in 4,6% of samples (all without chronic sun-induced damage and mainly in acral an… (full text at CIViC) PMID 24132921 · Dai et al., 2013 · Open in CIViC | civic |
| PDGFRA P577S1 | ||||||||
| Crenolanib + ImatinibSubstitutes | Melanoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1974PDGFRA mutations (exon 12, 14, 18) were assessed in 351 melanoma patient samples. 18 different mutations were detected in 4,6% of samples (all without chronic sun-induced damage and mainly in acral an… (full text at CIViC) PMID 24132921 · Dai et al., 2013 · Open in CIViC | civic |
| PDGFRA R841K1 | ||||||||
| Crenolanib + ImatinibSubstitutes | Melanoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1975PDGFRA mutations (exon 12, 14, 18) were assessed in 351 melanoma patient samples. 18 different mutations were detected in 4.6% of samples (all without chronic sun-induced damage and mainly in acral an… (full text at CIViC) PMID 24132921 · Dai et al., 2013 · Open in CIViC | civic |
| PDGFRA V658A2 | ||||||||
| Crenolanib | Melanoma | Predictive | D | Supports Sensitivity Response | 3 | submitted | EID8890PDGFRA mutations (exon 12, 14, 18) were assessed in 351 melanoma patient samples. 18 different mutations were detected in 4.6% of samples (all without chronic sun-induced damage and mainly in acral an… (full text at CIViC) PMID 24132921 · Dai et al., 2013 · Open in CIViC | civic |
| Imatinib | Melanoma | Predictive | D | Supports Resistance | 3 | submitted | EID8889PDGFRA mutations (exon 12, 14, 18) were assessed in 351 melanoma patient samples. 18 different mutations were detected in 4.6% of samples (all without chronic sun-induced damage and mainly in acral an… (full text at CIViC) PMID 24132921 · Dai et al., 2013 · Open in CIViC | civic |