Publication
Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (12)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 12
- cancerGastrointestinal Stromal Tumorcivic_curation1.00
- drugImatinibcivic_curation1.00
- geneKITcivic_curation1.00
- genePDGFRAcivic_curation1.00
- variantKIT Exon 11 Mutationcivic_curation1.00
- variantKIT Exon 9 Mutationcivic_curation1.00
- variantKIT EXPRESSIONcivic_curation1.00
- variantKIT F506_F508DUPcivic_curation1.00
- variantKIT K484_G487DELcivic_curation1.00
- variantKIT T417_D419delinsYcivic_curation1.00
- variantPDGFRA Exon 18 Mutationcivic_curation1.00
- variantPDGFRA V561Dcivic_curation1.00
Curated evidence
Evidence citing this paper (8)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 18955451
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| KIT Exon 11 Mutation1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | B | Supports Sensitivity Response | 4 | accepted | EID2471This prospective study of 397 patients with incurable (i.e. metastatic or unresectable) CD117-positive Gastrointestinal stromal tumors (GISTs) examined the relationship between KIT genotype and treatm… (full text at CIViC) PMID 18955451 · Heinrich et al., 2008 · Open in CIViC | civic |
| KIT Exon 9 Mutation1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | B | Supports Reduced Sensitivity | 2 | accepted | EID2477This prospective study of 397 patients with incurable (i.e. metastatic or unresectable) CD117-positive Gastrointestinal stromal tumors (GISTs) examined the relationship between KIT genotype and treatm… (full text at CIViC) PMID 18955451 · Heinrich et al., 2008 · Open in CIViC | civic |
| KIT EXPRESSION1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | B | Supports Sensitivity Response | 2 | accepted | EID2480In a prospective phase III study (SWOG S0033/CALGB 150105) of 407 patients with gastrointestinal stromal tumors (GISTs), 397 patients were observed to be CD117-positive (i.e. KIT-positive) and 10 pati… (full text at CIViC) PMID 18955451 · Heinrich et al., 2008 · Open in CIViC | civic |
| KIT F506_F508DUP1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | C | Does Not Support Sensitivity Response | 1 | accepted | EID2441This patient was part of a larger cohort of 397 patients with incurable (i.e. metastatic or unresectable) CD117-positive Gastrointestinal stromal tumors (GISTs) enrolled in the North American phase II… (full text at CIViC) PMID 18955451 · Heinrich et al., 2008 · Open in CIViC | civic |
| KIT K484_G487DEL1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | C | Supports Sensitivity Response | 1 | accepted | EID2465This patient was from a larger cohort of 397 patients with incurable (i.e. metastatic or unresectable) CD117-positive Gastrointestinal stromal tumors (GISTs) enrolled in the North American phase III s… (full text at CIViC) PMID 18955451 · Heinrich et al., 2008 · Open in CIViC | civic |
| KIT T417_D419delinsY1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | C | Supports Sensitivity Response | 2 | accepted | EID2417This patient was part of a larger cohort of 397 patients with incurable (i.e. metastatic or unresectable) CD117-positive Gastrointestinal stromal tumors (GISTs) enrolled in the North American phase II… (full text at CIViC) PMID 18955451 · Heinrich et al., 2008 · Open in CIViC | civic |
| PDGFRA Exon 18 Mutation1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | C | Does Not Support Sensitivity Response | 1 | accepted | EID2486These four patients were part of a larger cohort of 397 patients with incurable (i.e. metastatic or unresectable) CD117-positive Gastrointestinal stromal tumors (GISTs) enrolled in the North American … (full text at CIViC) PMID 18955451 · Heinrich et al., 2008 · Open in CIViC | civic |
| PDGFRA V561D1 | ||||||||
| Imatinib | Gastrointestinal Stromal Tumor | Predictive | C | Supports Sensitivity Response | 1 | accepted | EID2474This case study examines one patient from a larger cohort of 397 patients with incurable (i.e. metastatic or unresectable) CD117-positive Gastrointestinal stromal tumors (GISTs) enrolled in the North … (full text at CIViC) PMID 18955451 · Heinrich et al., 2008 · Open in CIViC | civic |