PDGFRA K385

CI-VAR-00002123Explore in graph →CIViC 4177

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Myxoid Glioneuronal Tumor2
PDGFRA K385	(diagnostic)	Diagnostic	C	Supports Positive	3	submitted	EID10669 Mutations at codon K385 are specific to glial and glioneuronal tumors. In addition, tumors with these mutations do not typically have other pathogenic mutations in other typical brain-cancer-associate… (full text at CIViC) PMID 30006677 · Solomon et al., 2018 · Open in CIViC	civic
PDGFRA K385	(diagnostic)	Diagnostic	C	Supports Positive	3	submitted	EID10670 PDGFRA K385L (6) or K385I (2) mutations were identified as the sole somatic pathogenic alteration in 8 patients with low-grade glioneuronal tumors; furthering defining "Myxoid glioneuronal tumor, PDGF… (full text at CIViC) PMID 31609499 · Lucas et al., 2020 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.