Gene

ABL1

ABL proto-oncogene 1, non-receptor tyrosine kinase

Explore in graph →CI-GENE-00000153HGNC:76 ENSG00000097007 NCBI 25 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (617)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 601–617 of 617 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ABL1 Fusion2
Imatinib	B Lymphoblastic Leukemia/LymphomaCURATED_BROADER	Predictive	C	Supports Reduced Sensitivity	1

Cohorts

Alteration frequency by cohort (122)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved122 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Lung Adenocarcinoma (MSK, J Thorac Oncol 2020) luad_mskcc_2020	Lung Adenocarcinoma	Ssm	13

Literature

Linked publications (65)

25 per page, newest first.

pubmedPublishedShowing 51–65 of 65 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

RCSD1-ABL1 Translocation Associated with IKZF1 Gene Deletion in B-Cell Acute Lymphoblastic Leukemia.
· Case Rep Hematol · 2015 · PMID 26600955 · validated civic_curation pubmed
Diagnostic evaluation of RNA sequencing for the detection of genetic abnormalities associated with Ph-like acute lymphoblastic leukemia (ALL).
· Leuk Lymphoma · 2017 · PMID 27855558 · validated civic_curation pubmed
BCR-ABL1-like B-Lymphoblastic Leukemia/Lymphoma with FOXP1-ABL1 Rearrangement: Comprehensive Laboratory Identification Allowing Tyrosine Kinase Inhibitor Use.
· Lab Med · 2019 · PMID 30938769 · validated civic_curation pubmed
SNX2-ABL1-positive acute lymphoblastic leukemia possibly has a poor prognosis.
· Leuk Lymphoma · 2017 · PMID 28278724 · validated

ABL1 Fusion1
(oncogenic)	T Acute Lymphoblastic LeukemiaCURATED_BROADER	Oncogenic	C	Supports Oncogenicity	3	submitted	EID13210 This retrospective study of COG ALL cases from a 5 year period identified 10 of 40 T-ALL cases with an ABL1 rearrangement. One 3 year old patient had a novel complex rearrangement between TNRC6B and A… (full text at CIViC) PMID 30803551 · Papenhausen et al., 2019 · Open in CIViC	civic

ABL1 Fusion1

(oncogenic)

T Acute Lymphoblastic LeukemiaCURATED_BROADER

Oncogenic

Supports Oncogenicity

submitted

EID13210

This retrospective study of COG ALL cases from a 5 year period identified 10 of 40 T-ALL cases with an ABL1 rearrangement. One 3 year old patient had a novel complex rearrangement between TNRC6B and A… (full text at CIViC)

PMID 30803551 · Papenhausen et al., 2019 · Open in CIViC

ABL1 Fusion13
(prognostic)	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Prognostic	B	Supports Better Outcome	4	accepted	EID9149 A multicenter, retrospective, cohort study that included 122 paediatric patients (aged 1-18 years) with newly diagnosed ABL-class fusion B-cell acute lymphocytic leukemia who had not received tyrosine… (full text at CIViC) PMID 33357483 · den Boer et al., 2021 · Open in CIViC	civic
(oncogenic)	B Lymphoblastic Leukemia/LymphomaCURATED_BROADER	Oncogenic	B	Supports Oncogenicity	3	submitted	EID12638 In a multicentre retrospective cohort study of 122 paediatric patients (aged 1-18 years) with newly diagnosed ABL-class fusion (ABL1 fusion-positive, ABL2 fusion-positive, CSF1R fusion-positive, and P… (full text at CIViC) PMID 33357483 · den Boer et al., 2021 · Open in CIViC	civic
(diagnostic)	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	C	Supports Positive	2	accepted	EID9077 This study included 1389 cases of high-risk pediatric B-ALL, of which 284 were identified by TaqMan Low Density Array to have a BCR-ABL1-like (Ph-like) gene expression signature. RT-PCR or RNAseq perf… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC	civic
〃	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	C	Supports Positive	2	accepted	EID9152 Study comprised 574 children with newly diagnosed B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and focused on B-other/BCR-ABL-like which were identified by hierarchical clustering of gene e… (full text at CIViC) PMID 27894077 · Boer et al., 2017 · Open in CIViC	civic
〃	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	C	Supports Positive	2	accepted	EID11619 B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 3 of 4 patients (ages 2.2, 2.6, a… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
(oncogenic)	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Oncogenic	C	Supports Oncogenicity	2	submitted	EID12635 A study of 204 children with B-cell precursor acute lymphoblastic leukemia from three Dutch trials (DCOG ALL-8, 9, 10) and two German trials (COALL 06-97, 07-03) included 73 cases of BCR-ABL1-like B-A… (full text at CIViC) Open in CIViC	civic
〃	B Lymphoblastic Leukemia/LymphomaCURATED_BROADER	Oncogenic	C	Supports Oncogenicity	1	accepted	EID9151 A 18-month-old female with B-cell acute lymphoblastic leukemia. Chromosome and FISH analysis using a BCR-ABL1 probe confirmed the involvement of ABL1 in a t(9;10)(q34;q22.3) translocation. Follow-up m… (full text at CIViC) PMID 18007576 · Soler et al., 2008 · Open in CIViC	civic
〃	Malignant NeoplasmALIAS	Oncogenic	D	Supports Oncogenicity	3	submitted	EID11117 BA/F3 cells transfected with ZMIZ1-ABL1 fusion were able to proliferate in the absence of IL3 by multiple orders of magnitude over 8 days, while cells transduced with empty vector failed to proliferat… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
Dasatinib	Malignant NeoplasmALIAS	Predictive	D	Supports Sensitivity Response	3	rejected	EID11118 IL3 indépendant Ba/F3 cells transduced with ZMIZ1-ABL1 driver fusion were treated with dasatinib. ZMIZ1-ABL1 cells had IC50 of 1-2 nM, whereas cells transduced with the driver PAX5-JAK2 were not respo… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
Azacitidine + DasatinibCombination	Chronic Myelomonocytic Leukemia	Predictive	C	Supports Sensitivity Response	4	submitted	EID12636 A 60-year-old presented with bloating and shortness of breath. Records showed leukocytosis (white blood cell count of 12 × 109/L) with enlarged spleen. WBC was 16.43 × 10^9/L. abdominal ultrasound sho… (full text at CIViC) PMID 36694063 · Liu et al., 2023 · Open in CIViC	civic
Chemotherapy + DasatinibCombination	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Predictive	C	Supports Sensitivity Response	4	submitted	EID11119 An 11 year old female (46,XX) had B-ALL. The patient received a 4-drug induction and end induction day 29 MRD was 5.4%. LDA card was used to analyze the patient and the leukemia was determined to be P… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
Chemotherapy + ImatinibCombination	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Predictive	C	Supports Sensitivity Response	4	submitted	EID12615 A pediatric patient had a hematopathologic diagnosis of B-ALL determined through bone marrow aspirate analysis. The patient had a hemoglobin level of 3 g/dL, severe neutropenia, and a normal platelet … (full text at CIViC) PMID 38749501 · Booth et al., 2025 · Open in CIViC	civic
Dasatinib + ImatinibSubstitutes	Malignant NeoplasmALIAS	Predictive	D	Supports Sensitivity Response	3	submitted	EID11120 IL3 indépendant Ba/F3 cells transduced with ZMIZ1-ABL1 driver fusion were treated with dasatinib. ZMIZ1-ABL1 cells had IC50 of 1-2 nM, whereas cells transduced with the driver PAX5-JAK2 were not respo… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic