ABL1 L387F

CI-VAR-00002344Explore in graph →NP_005148.2:p.Leu387PheNM_005157.5:c.1161G>CCIViC 1232

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Chronic Myeloid Leukemia, BCR-ABL1 Positive4
BCR::ABL1 Fusion AND ABL1 L387F	Bosutinib	Predictive	C	Supports Resistance	1	accepted	EID4552 This was a retrospective study of dasatinib and/or nilotinib-resistant or -intolerant patients pretreated with imatinib aimed at evaluating the efficacy of bosutanib monotherapy. All patients had chro… (full text at CIViC) PMID 22371878 · Khoury et al., 2012 · Open in CIViC	civic
BCR::ABL1 Fusion AND ABL1 L387F	Bosutinib	Predictive	C	Supports Sensitivity Response	2	submitted	EID4553 In a retrospective study of 288 imatinib-resistant or -intolerant, Philadelphia chromosome BCR-ABL1 fusion positive, chronic myeloid leukemia (chronic phase) patients, a patient with the L387F mutatio… (full text at CIViC) PMID 21865346 · Cortes et al., 2011 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.