ABL1 F311I

CI-VAR-00001101Explore in graph →NP_005148.2:p.Phe311IleNM_005157.5:c.931T>ACIViC 1507 rs137853304

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Chronic Myeloid Leukemia, BCR-ABL1 Positive4
ABL1 F311I	Imatinib Mesylate	Predictive	D	Supports Resistance	2	rejected	EID6248 In an in vitro study, stochastic mutations were introduced into the ABL1 region of a stably expressed p210 BCR-ABL fusion in Ba/F3 cells using N-ethyl-N-nitrosourea mutagenesis. Resulting clones were … (full text at CIViC) PMID 16772610 · Bradeen et al., 2006 · Open in CIViC	civic
BCR::ABL1 Fusion AND ABL1 F311I	Axitinib	Predictive	D	Supports Resistance	2	accepted	EID4477 In an in vitro study, pro-B Ba/F3 cell line expressing F311I mutation in the ABL1 portion of the BCR-ABL1 fusion protein (overexpression) demonstrated resistance to axitinib treatment (IC50: 935.6nM),… (full text at CIViC) PMID 26582647 · Zabriskie et al., 2016 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.