ABL1 M244V

CI-VAR-00002581Explore in graph →NP_005148.2:p.Met244ValNM_005157.5:c.730A>GCIViC 4597 rs121913456

Curated evidence

Evidence by cancer (20 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–20 of 20 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Lymphoblastic Leukemia1
BCR::ABL1 Fusion AND ABL1 M244V	Dasatinib	Predictive	C	Supports Resistance	3	submitted	EID4387 In a retrospective study of 84 imatinib-resistant or -intolerant Philadelphia chromosome BCR-ABL1 fusion positive (Ph+) chronic myeloid leukemia (in accelerated-phase or with blast crisis) or Ph+ acut… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
Chronic Myeloid Leukemia, BCR-ABL1 Positive16
BCR::ABL1 Fusion AND ABL1 L364I AND ABL1 M244V	Dasatinib	Predictive	C	Does Not Support Resistance	3	accepted	EID7943 Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in myeloid blast crisis had the BCR-ABL1 fusion with M244V/L364I, M244V/L364I/N53S, M244V/L364I/M458T, L364I/… (full text at CIViC)

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Malignant Neoplasm3
BCR::ABL1 Fusion AND ABL1 M244V	Imatinib	Predictive	D	Supports Sensitivity Response	3	accepted	EID2638 A panel of 16 mutations seen in imatinib CML patents were used to evaluate the effectiveness of drug binding. All mutations were compared with non-mutated BCR-ABL protein and evaluated for antiprolife… (full text at CIViC) PMID 15930265 · O'Hare et al., 2005 · Open in CIViC	civic
BCR::ABL1 Fusion AND ABL1 M244V	Bafetinib + ImatinibSubstitutes	Predictive	D	Supports Resistance	3	accepted	EID7850 In an in vitro study, a Ba/F3 cell line stably expressing the M244V mutation in the ABL1 portion of the BCR-ABL1 fusion protein was associated with resistance to imatinib and bafetinib (INNO-406) trea… (full text at CIViC) PMID 18191450 · Deguchi et al., 2008 · Open in CIViC	civic
BCR::ABL1 Fusion AND ABL1 M244V	Dasatinib + NilotinibSubstitutes	Predictive	D	Does Not Support Resistance	3	accepted	EID2640 In an in vitro study, a Ba/F3 cell line stably expressing the M244V mutation in the ABL1 portion of the BCR-ABL1 fusion protein was associated with similar sensitivity to dasatinib and nilotinib treat… (full text at CIViC) PMID 18191450 · Deguchi et al., 2008 · Open in CIViC	civic