Cancer Family
Malignant Neoplasm
CI-CAN-00000025CAExplore in graph →
20,108 active trials259 approved drugs3,741 evidence items
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Cancer Family
CI-CAN-00000025CAExplore in graph →
Genomics
442 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
28 cases with simple somatic mutation data · 83 cases total · 2026-02-17 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 26 |
| 28 |
| 92.9% |
| cbioportal |
| 2 | APC | Ssm | 23 | 28 | 82.1% | cbioportal |
| 3 | KRAS | Ssm | 10 | 28 | 35.7% | cbioportal |
| 4 | FBXW7 | Ssm | 5 | 28 | 17.9% | cbioportal |
| 5 | TCF7L2 | Ssm | 5 | 28 | 17.9% | cbioportal |
| 6 | PIK3CA | Ssm | 4 | 28 | 14.3% | cbioportal |
| 7 | ATM | Ssm | 3 | 28 | 10.7% | cbioportal |
| 8 | SOX9 | Ssm | 3 | 28 | 10.7% | cbioportal |
| 13 | INHBA | Ssm | 2 | 28 | 7.1% | cbioportal |
| 9 | BARD1 | Ssm | 2 | 28 | 7.1% | cbioportal |
| 14 | JUN | Ssm | 2 | 28 | 7.1% | cbioportal |
| 19 | RB1 | Ssm | 2 | 28 | 7.1% | cbioportal |
| 12 | GNA11 | Ssm | 2 | 28 | 7.1% | cbioportal |
| 15 | KMT2B | Ssm | 2 | 28 | 7.1% | cbioportal |
| 16 | KMT2C | Ssm | 2 | 28 | 7.1% | cbioportal |
| 18 | NRAS | Ssm | 2 | 28 | 7.1% | cbioportal |
| 10 | CARD11 | Ssm | 2 | 28 | 7.1% | cbioportal |
| 20 | SMAD4 | Ssm | 2 | 28 | 7.1% | cbioportal |
| 17 | MDC1 | Ssm | 2 | 28 | 7.1% | cbioportal |
| 11 | FLT4 | Ssm | 2 | 28 | 7.1% | cbioportal |
| 41 | EZH2 | Ssm | 1 | 28 | 3.6% | cbioportal |
| 42 | FANCA | Ssm | 1 | 28 | 3.6% | cbioportal |
| 43 | FANCC | Ssm | 1 | 28 | 3.6% | cbioportal |
| 44 | FAT1 | Ssm | 1 | 28 | 3.6% | cbioportal |
| 45 | FLCN | Ssm | 1 | 28 | 3.6% | cbioportal |
| 46 | FLT1 | Ssm | 1 | 28 | 3.6% | cbioportal |
| 47 | GATA2 | Ssm | 1 | 28 | 3.6% | cbioportal |
| 48 | GATA3 | Ssm | 1 | 28 | 3.6% | cbioportal |
| 49 | GNAQ | Ssm | 1 | 28 | 3.6% | cbioportal |
| 50 | GRIN2A | Ssm | 1 | 28 | 3.6% | cbioportal |
Data updated 22 days agoSource updated 2026-02-17