Cancer Family
Malignant Neoplasm
CI-CAN-00000025CAExplore in graph →
20,108 active trials259 approved drugs3,741 evidence items
Loading cancer entity…
Cancer Family
CI-CAN-00000025CAExplore in graph →
Genomics
442 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
183 cases with simple somatic mutation data · 183 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 95 |
| 183 |
| 51.9% |
| cbioportal |
| 2 | TTN | Ssm | 83 | 183 | 45.4% | cbioportal |
| 3 | MUC16 | Ssm | 71 | 183 | 38.8% | cbioportal |
| 4 | USH2A | Ssm | 64 | 183 | 35% | cbioportal |
| 6 | RYR2 | Ssm | 62 | 183 | 33.9% | cbioportal |
| 5 | CSMD3 | Ssm | 62 | 183 | 33.9% | cbioportal |
| 7 | LRP1B | Ssm | 59 | 183 | 32.2% | cbioportal |
| 8 | SPTA1 | Ssm | 56 | 183 | 30.6% | cbioportal |
| 10 | XIRP2 | Ssm | 49 | 183 | 26.8% | cbioportal |
| 11 | ZFHX4 | Ssm | 49 | 183 | 26.8% | cbioportal |
| 9 | KRAS | Ssm | 49 | 183 | 26.8% | cbioportal |
| 13 | FLG | Ssm | 48 | 183 | 26.2% | cbioportal |
| 12 | FAT3 | Ssm | 48 | 183 | 26.2% | cbioportal |
| 14 | PCLO | Ssm | 43 | 183 | 23.5% | cbioportal |
| 15 | PCDH15 | Ssm | 40 | 183 | 21.9% | cbioportal |
| 16 | OBSCN | Ssm | 37 | 183 | 20.2% | cbioportal |
| 23 | SI | Ssm | 35 | 183 | 19.1% | cbioportal |
| 21 | PAPPA2 | Ssm | 35 | 183 | 19.1% | cbioportal |
| 18 | APOB | Ssm | 35 | 183 | 19.1% | cbioportal |
| 22 | RYR3 | Ssm | 35 | 183 | 19.1% | cbioportal |
| 17 | ABCA13 | Ssm | 35 | 183 | 19.1% | cbioportal |
| 20 | MUC17 | Ssm | 35 | 183 | 19.1% | cbioportal |
| 19 | CSMD1 | Ssm | 35 | 183 | 19.1% | cbioportal |
| 24 | NRXN1 | Ssm | 34 | 183 | 18.6% | cbioportal |
| 25 | COL11A1 | Ssm | 32 | 183 | 17.5% | cbioportal |
| 28 | RP1L1 | Ssm | 32 | 183 | 17.5% | cbioportal |
| 26 | EGFR | Ssm | 32 | 183 | 17.5% | cbioportal |
| 27 | RELN | Ssm | 32 | 183 | 17.5% | cbioportal |
| 29 | ADGRL3 | Ssm | 31 | 183 | 16.9% | cbioportal |
| 30 | DNAH9 | Ssm | 31 | 183 | 16.9% | cbioportal |
Data updated 22 days agoSource updated 2026-01-07