Cancer Family
Malignant Neoplasm
CI-CAN-00000025CAExplore in graph →
20,108 active trials259 approved drugs3,741 evidence items
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Cancer Family
CI-CAN-00000025CAExplore in graph →
Genomics
442 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
122 cases with simple somatic mutation data · 122 cases total · 2026-02-11 · mapped to Melanoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TTN | Ssm |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 83 |
| 122 |
| 68% |
| cbioportal |
| 2 | MUC16 | Ssm | 77 | 122 | 63.1% | cbioportal |
| 3 | DNAH5 | Ssm | 60 | 122 | 49.2% | cbioportal |
| 4 | PCLO | Ssm | 56 | 122 | 45.9% | cbioportal |
| 5 | BRAF | Ssm | 50 | 122 | 41% | cbioportal |
| 6 | RP1 | Ssm | 47 | 122 | 38.5% | cbioportal |
| 7 | DNAH6 | Ssm | 46 | 122 | 37.7% | cbioportal |
| 8 | LRP1B | Ssm | 45 | 122 | 36.9% | cbioportal |
| 9 | ANK3 | Ssm | 44 | 122 | 36.1% | cbioportal |
| 11 | NEB | Ssm | 43 | 122 | 35.2% | cbioportal |
| 10 | CSMD1 | Ssm | 43 | 122 | 35.2% | cbioportal |
| 14 | OBSCN | Ssm | 42 | 122 | 34.4% | cbioportal |
| 12 | APOB | Ssm | 42 | 122 | 34.4% | cbioportal |
| 13 | DNAH7 | Ssm | 42 | 122 | 34.4% | cbioportal |
| 15 | PKHD1L1 | Ssm | 41 | 122 | 33.6% | cbioportal |
| 17 | MUC17 | Ssm | 40 | 122 | 32.8% | cbioportal |
| 16 | FSIP2 | Ssm | 40 | 122 | 32.8% | cbioportal |
| 18 | ADGRV1 | Ssm | 39 | 122 | 32% | cbioportal |
| 19 | FLG | Ssm | 39 | 122 | 32% | cbioportal |
| 20 | MXRA5 | Ssm | 38 | 122 | 31.1% | cbioportal |
| 22 | ZFHX4 | Ssm | 38 | 122 | 31.1% | cbioportal |
| 21 | SYNE1 | Ssm | 38 | 122 | 31.1% | cbioportal |
| 23 | NRAS | Ssm | 37 | 122 | 30.3% | cbioportal |
| 24 | DNAH9 | Ssm | 36 | 122 | 29.5% | cbioportal |
| 25 | CFAP54 | Ssm | 35 | 122 | 28.7% | cbioportal |
| 26 | THSD7B | Ssm | 34 | 122 | 27.9% | cbioportal |
| 27 | FAT4 | Ssm | 33 | 122 | 27% | cbioportal |
| 28 | WDFY4 | Ssm | 33 | 122 | 27% | cbioportal |
| 29 | ABCA13 | Ssm | 32 | 122 | 26.2% | cbioportal |
| 30 | CSMD2 | Ssm | 32 | 122 | 26.2% | cbioportal |
Data updated 22 days agoSource updated 2026-02-11