Cancer Family
Malignant Neoplasm
CI-CAN-00000025CAExplore in graph →
20,108 active trials259 approved drugs3,741 evidence items
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Cancer Family
CI-CAN-00000025CAExplore in graph →
Genomics
442 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
2,433 cases with simple somatic mutation data · 2,509 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 975 |
| 2,433 |
| 40.1% |
| cbioportal |
| 2 | TP53 | Ssm | 864 | 2,433 | 35.5% | cbioportal |
| 3 | MUC16 | Ssm | 409 | 2,433 | 16.8% | cbioportal |
| 4 | AHNAK2 | Ssm | 395 | 2,433 | 16.2% | cbioportal |
| 5 | SYNE1 | Ssm | 294 | 2,433 | 12.1% | cbioportal |
| 6 | KMT2C | Ssm | 280 | 2,433 | 11.5% | cbioportal |
| 7 | GATA3 | Ssm | 269 | 2,433 | 11.1% | cbioportal |
| 8 | CDH1 | Ssm | 236 | 2,433 | 9.7% | cbioportal |
| 9 | MAP3K1 | Ssm | 236 | 2,433 | 9.7% | cbioportal |
| 10 | DNAH11 | Ssm | 226 | 2,433 | 9.3% | cbioportal |
| 11 | AHNAK | Ssm | 220 | 2,433 | 9% | cbioportal |
| 12 | DNAH2 | Ssm | 186 | 2,433 | 7.6% | cbioportal |
| 13 | KMT2D | Ssm | 176 | 2,433 | 7.2% | cbioportal |
| 14 | USH2A | Ssm | 170 | 2,433 | 7% | cbioportal |
| 15 | DNAH5 | Ssm | 167 | 2,433 | 6.9% | cbioportal |
| 17 | RYR2 | Ssm | 161 | 2,433 | 6.6% | cbioportal |
| 16 | HERC2 | Ssm | 161 | 2,433 | 6.6% | cbioportal |
| 18 | PDE4DIP | Ssm | 146 | 2,433 | 6% | cbioportal |
| 19 | AKAP9 | Ssm | 143 | 2,433 | 5.9% | cbioportal |
| 20 | TG | Ssm | 137 | 2,433 | 5.6% | cbioportal |
| 21 | BIRC6 | Ssm | 128 | 2,433 | 5.3% | cbioportal |
| 22 | UTRN | Ssm | 124 | 2,433 | 5.1% | cbioportal |
| 23 | TBX3 | Ssm | 123 | 2,433 | 5.1% | cbioportal |
| 24 | COL6A3 | Ssm | 119 | 2,433 | 4.9% | cbioportal |
| 25 | LAMA2 | Ssm | 117 | 2,433 | 4.8% | cbioportal |
| 26 | NOTCH1 | Ssm | 116 | 2,433 | 4.8% | cbioportal |
| 27 | ARID1A | Ssm | 114 | 2,433 | 4.7% | cbioportal |
| 28 | CBFB | Ssm | 112 | 2,433 | 4.6% | cbioportal |
| 29 | COL12A1 | Ssm | 103 | 2,433 | 4.2% | cbioportal |
| 30 | NCOR2 | Ssm | 102 | 2,433 | 4.2% | cbioportal |
Data updated 22 days agoSource updated 2026-01-05