Cancer Family
Malignant Neoplasm
CI-CAN-00000025CAExplore in graph →
20,108 active trials259 approved drugs3,741 evidence items
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Cancer Family
CI-CAN-00000025CAExplore in graph →
Genomics
442 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
507 cases with simple somatic mutation data · 825 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 190 |
| 507 |
| 37.5% |
| cbioportal |
| 2 | PIK3CA | Ssm | 179 | 507 | 35.3% | cbioportal |
| 3 | TTN | Ssm | 75 | 507 | 14.8% | cbioportal |
| 4 | GATA3 | Ssm | 54 | 507 | 10.7% | cbioportal |
| 5 | MAP3K1 | Ssm | 39 | 507 | 7.7% | cbioportal |
| 6 | KMT2C | Ssm | 38 | 507 | 7.5% | cbioportal |
| 7 | MUC16 | Ssm | 38 | 507 | 7.5% | cbioportal |
| 8 | CDH1 | Ssm | 34 | 507 | 6.7% | cbioportal |
| 9 | USH2A | Ssm | 27 | 507 | 5.3% | cbioportal |
| 10 | BRCA2 | Ssm | 24 | 507 | 4.7% | cbioportal |
| 11 | RYR2 | Ssm | 23 | 507 | 4.5% | cbioportal |
| 12 | FLG | Ssm | 22 | 507 | 4.3% | cbioportal |
| 13 | MAP2K4 | Ssm | 21 | 507 | 4.1% | cbioportal |
| 14 | ATM | Ssm | 20 | 507 | 3.9% | cbioportal |
| 15 | FAT3 | Ssm | 20 | 507 | 3.9% | cbioportal |
| 18 | OBSCN | Ssm | 19 | 507 | 3.7% | cbioportal |
| 16 | HMCN1 | Ssm | 19 | 507 | 3.7% | cbioportal |
| 17 | NEB | Ssm | 19 | 507 | 3.7% | cbioportal |
| 19 | BRCA1 | Ssm | 18 | 507 | 3.6% | cbioportal |
| 20 | MUC17 | Ssm | 18 | 507 | 3.6% | cbioportal |
| 22 | RUNX1 | Ssm | 18 | 507 | 3.6% | cbioportal |
| 21 | PTEN | Ssm | 18 | 507 | 3.6% | cbioportal |
| 25 | NCOR1 | Ssm | 17 | 507 | 3.4% | cbioportal |
| 23 | LRP2 | Ssm | 17 | 507 | 3.4% | cbioportal |
| 26 | SYNE1 | Ssm | 17 | 507 | 3.4% | cbioportal |
| 24 | MUC4 | Ssm | 17 | 507 | 3.4% | cbioportal |
| 27 | CSMD1 | Ssm | 16 | 507 | 3.2% | cbioportal |
| 28 | SYNE2 | Ssm | 16 | 507 | 3.2% | cbioportal |
| 29 | ZFHX4 | Ssm | 16 | 507 | 3.2% | cbioportal |
| 31 | DMD | Ssm | 15 | 507 | 3% | cbioportal |
Data updated 22 days agoSource updated 2026-01-05