Cancer Family
Malignant Neoplasm
CI-CAN-00000025CAExplore in graph →
20,108 active trials259 approved drugs3,741 evidence items
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Cancer Family
CI-CAN-00000025CAExplore in graph →
Genomics
442 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
982 cases with simple somatic mutation data · 1,108 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | PIK3CA | Ssm |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 319 |
| 982 |
| 32.5% |
| cbioportal |
| 2 | TP53 | Ssm | 301 | 982 | 30.7% | cbioportal |
| 3 | TTN | Ssm | 161 | 982 | 16.4% | cbioportal |
| 4 | CDH1 | Ssm | 112 | 982 | 11.4% | cbioportal |
| 5 | GATA3 | Ssm | 97 | 982 | 9.9% | cbioportal |
| 6 | MUC16 | Ssm | 74 | 982 | 7.5% | cbioportal |
| 7 | MAP3K1 | Ssm | 71 | 982 | 7.2% | cbioportal |
| 8 | KMT2C | Ssm | 70 | 982 | 7.1% | cbioportal |
| 9 | MUC12 | Ssm | 54 | 982 | 5.5% | cbioportal |
| 10 | MUC4 | Ssm | 53 | 982 | 5.4% | cbioportal |
| 12 | USH2A | Ssm | 45 | 982 | 4.6% | cbioportal |
| 11 | FLG | Ssm | 45 | 982 | 4.6% | cbioportal |
| 13 | SYNE1 | Ssm | 43 | 982 | 4.4% | cbioportal |
| 14 | RYR2 | Ssm | 42 | 982 | 4.3% | cbioportal |
| 15 | NCOR1 | Ssm | 40 | 982 | 4.1% | cbioportal |
| 16 | DMD | Ssm | 39 | 982 | 4% | cbioportal |
| 18 | NEB | Ssm | 37 | 982 | 3.8% | cbioportal |
| 20 | SYNE2 | Ssm | 37 | 982 | 3.8% | cbioportal |
| 19 | RYR3 | Ssm | 37 | 982 | 3.8% | cbioportal |
| 17 | HMCN1 | Ssm | 37 | 982 | 3.8% | cbioportal |
| 21 | MUC5B | Ssm | 36 | 982 | 3.7% | cbioportal |
| 23 | HUWE1 | Ssm | 35 | 982 | 3.6% | cbioportal |
| 22 | FAT3 | Ssm | 35 | 982 | 3.6% | cbioportal |
| 24 | PTEN | Ssm | 35 | 982 | 3.6% | cbioportal |
| 26 | LRP2 | Ssm | 34 | 982 | 3.5% | cbioportal |
| 25 | HRNR | Ssm | 34 | 982 | 3.5% | cbioportal |
| 30 | ZFHX4 | Ssm | 33 | 982 | 3.4% | cbioportal |
| 27 | OBSCN | Ssm | 33 | 982 | 3.4% | cbioportal |
| 29 | SPTA1 | Ssm | 33 | 982 | 3.4% | cbioportal |
| 28 | SPEN | Ssm | 33 | 982 | 3.4% | cbioportal |
Data updated 22 days agoSource updated 2026-01-05