Lung Carcinoma — Genomics

Lung Carcinoma — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

40 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

APOLLO1: Proteogenomic characterization of lung adenocarcinoma APOLLO-LUADAPOLLO

87 cases with simple somatic mutation data · 87 cases total · Data Release 46.0 · mapped to Lung Adenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

CDDP Integrative Analysis of Lung Adenocarcinoma (Phase 2) CDDP_EAGLE-1CDDP_EAGLE

50 cases with simple somatic mutation data · 50 cases total · Data Release 46.0 · mapped to Lung Adenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	SPTA1	Ssm	35	50	70%	gdc
1	PRPF3	Ssm	35	50	70%	gdc
12	GBA	Ssm	34	50	68%	gdc
3	ECM1	Ssm	34	50	68%	gdc
4	SETDB1	Ssm	34	50	68%	gdc
5	CA14	Ssm	34	50	68%	gdc
6	PRUNE1	Ssm	34	50	68%	gdc
7	ADAMTSL4	Ssm	34	50	68%	gdc
8	PIP5K1A	Ssm	34	50	68%	gdc
9	MRPS21	Ssm	34	50	68%	gdc
10	ANP32E	Ssm	34	50	68%	gdc
11	RPRD2	Ssm	34	50	68%	gdc
13	TARS2	Ssm	34	50	68%	gdc
14	C1orf54	Ssm	34	50	68%	gdc
15	SYT11	Ssm	34	50	68%	gdc
16	CTXND2	Ssm	34	50	68%	gdc
17	MTX1	Ssm	34	50	68%	gdc
18	CIART	Ssm	34	50	68%	gdc
19	TTN	Ssm	34	50	68%	gdc
20	APH1A	Ssm	34	50	68%	gdc
21	CERS2	Ssm	34	50	68%	gdc
22	MSTO1	Ssm	33	50	66%	gdc
23	ANXA9	Ssm	33	50	66%	gdc
24	SCAMP3	Ssm	33	50	66%	gdc
25	CLK2	Ssm	33	50	66%	gdc
26	MLLT11	Ssm	33	50	66%	gdc
27	POGZ	Ssm	33	50	66%	gdc
28	GON4L	Ssm	33	50	66%	gdc
29	SEMA6C	Ssm	33	50	66%	gdc
30	RFX5	Ssm	33	50	66%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Lung Adenocarcinoma TCGA-LUADTCGA

573 cases with simple somatic mutation data · 585 cases total · Data Release 46.0 · mapped to Lung Adenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	RYR2	Ssm	413	573	72.1%	gdc
2	FLG	Ssm	406	573	70.9%	gdc
3	USH2A	Ssm	402	573	70.2%	gdc
4	SPTA1	Ssm	400	573	69.8%	gdc
5	TP53	Ssm	393	573	68.6%	gdc
6	FLG2	Ssm	388	573	67.7%	gdc
7	CSMD3	Ssm	383	573	66.8%	gdc
8	HRNR	Ssm	383	573	66.8%	gdc
11	ASH1L	Ssm	382	573	66.7%	gdc
10	TNN	Ssm	382	573	66.7%	gdc
9	TNR	Ssm	382	573	66.7%	gdc
12	HMCN1	Ssm	379	573	66.1%	gdc
13	MUC16	Ssm	376	573	65.6%	gdc
16	PAPPA2	Ssm	374	573	65.3%	gdc
14	CACNA1E	Ssm	374	573	65.3%	gdc
15	TCHH	Ssm	374	573	65.3%	gdc
17	ASTN1	Ssm	373	573	65.1%	gdc
18	KCNN3	Ssm	372	573	64.9%	gdc
19	NUP210L	Ssm	371	573	64.7%	gdc
20	ASPM	Ssm	371	573	64.7%	gdc
23	FCRL5	Ssm	370	573	64.6%	gdc
22	ADAR	Ssm	370	573	64.6%	gdc
21	ATP8B2	Ssm	370	573	64.6%	gdc
24	NPR1	Ssm	369	573	64.4%	gdc
26	PKLR	Ssm	369	573	64.4%	gdc
25	AQP10	Ssm	369	573	64.4%	gdc
33	IQGAP3	Ssm	368	573	64.2%	gdc
32	CHRNB2	Ssm	368	573	64.2%	gdc
31	TCHHL1	Ssm	368	573	64.2%	gdc
27	CLK2	Ssm	368	573	64.2%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Lung Adenocarcinoma (Broad, Cell 2012) luad_broadBroad

183 cases with simple somatic mutation data · 183 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	95	183	51.9%	cbioportal
2	TTN	Ssm	83	183	45.4%	cbioportal
3	MUC16	Ssm	71	183	38.8%	cbioportal
4	USH2A	Ssm	64	183	35%	cbioportal
5	CSMD3	Ssm	62	183	33.9%	cbioportal
6	RYR2	Ssm	62	183	33.9%	cbioportal
7	LRP1B	Ssm	59	183	32.2%	cbioportal
8	SPTA1	Ssm	56	183	30.6%	cbioportal
9	KRAS	Ssm	49	183	26.8%	cbioportal
11	ZFHX4	Ssm	49	183	26.8%	cbioportal
10	XIRP2	Ssm	49	183	26.8%	cbioportal
12	FAT3	Ssm	48	183	26.2%	cbioportal
13	FLG	Ssm	48	183	26.2%	cbioportal
14	PCLO	Ssm	43	183	23.5%	cbioportal
15	PCDH15	Ssm	40	183	21.9%	cbioportal
16	OBSCN	Ssm	37	183	20.2%	cbioportal
20	MUC17	Ssm	35	183	19.1%	cbioportal
18	APOB	Ssm	35	183	19.1%	cbioportal
17	ABCA13	Ssm	35	183	19.1%	cbioportal
19	CSMD1	Ssm	35	183	19.1%	cbioportal
23	SI	Ssm	35	183	19.1%	cbioportal
22	RYR3	Ssm	35	183	19.1%	cbioportal
21	PAPPA2	Ssm	35	183	19.1%	cbioportal
24	NRXN1	Ssm	34	183	18.6%	cbioportal
28	RP1L1	Ssm	32	183	17.5%	cbioportal
26	EGFR	Ssm	32	183	17.5%	cbioportal
25	COL11A1	Ssm	32	183	17.5%	cbioportal
27	RELN	Ssm	32	183	17.5%	cbioportal
30	DNAH9	Ssm	31	183	16.9%	cbioportal
29	ADGRL3	Ssm	31	183	16.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Adenocarcinoma (CAS, Cell 2020) luad_cas_2020CAS

103 cases with simple somatic mutation data · 103 cases total · 2026-01-19 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	53	103	51.5%	cbioportal
2	EGFR	Ssm	51	103	49.5%	cbioportal
3	TTN	Ssm	23	103	22.3%	cbioportal
4	RYR2	Ssm	15	103	14.6%	cbioportal
5	MUC16	Ssm	13	103	12.6%	cbioportal
8	OBSCN	Ssm	12	103	11.7%	cbioportal
6	AHNAK2	Ssm	12	103	11.7%	cbioportal
7	MUC17	Ssm	12	103	11.7%	cbioportal
9	ZNF536	Ssm	11	103	10.7%	cbioportal
10	APOB	Ssm	10	103	9.7%	cbioportal
11	CSMD3	Ssm	10	103	9.7%	cbioportal
12	FLG	Ssm	10	103	9.7%	cbioportal
13	HMCN1	Ssm	10	103	9.7%	cbioportal
16	FAT3	Ssm	9	103	8.7%	cbioportal
19	RYR1	Ssm	9	103	8.7%	cbioportal
21	USH2A	Ssm	9	103	8.7%	cbioportal
20	SPEG	Ssm	9	103	8.7%	cbioportal
17	MUC12	Ssm	9	103	8.7%	cbioportal
14	COL11A1	Ssm	9	103	8.7%	cbioportal
15	DMD	Ssm	9	103	8.7%	cbioportal
18	PLEC	Ssm	9	103	8.7%	cbioportal
30	TENM4	Ssm	8	103	7.8%	cbioportal
22	BRINP3	Ssm	8	103	7.8%	cbioportal
23	EYS	Ssm	8	103	7.8%	cbioportal
24	ICE1	Ssm	8	103	7.8%	cbioportal
25	MUC5B	Ssm	8	103	7.8%	cbioportal
26	PAPPA2	Ssm	8	103	7.8%	cbioportal
27	PCDH15	Ssm	8	103	7.8%	cbioportal
28	RELN	Ssm	8	103	7.8%	cbioportal
29	RYR3	Ssm	8	103	7.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Lung Adenocarcinoma (CPTAC, Cell 2020) luad_cptac_2020CPTAC

110 cases with simple somatic mutation data · 110 cases total · 2026-01-16 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	59	110	53.6%	cbioportal
2	EGFR	Ssm	38	110	34.5%	cbioportal
3	MUC16	Ssm	37	110	33.6%	cbioportal
5	TTN	Ssm	35	110	31.8%	cbioportal
4	RYR2	Ssm	35	110	31.8%	cbioportal
6	LRP1B	Ssm	34	110	30.9%	cbioportal
7	CSMD3	Ssm	33	110	30%	cbioportal
8	KRAS	Ssm	33	110	30%	cbioportal
9	USH2A	Ssm	28	110	25.5%	cbioportal
10	ZFHX4	Ssm	26	110	23.6%	cbioportal
11	FAT3	Ssm	23	110	20.9%	cbioportal
12	COL11A1	Ssm	22	110	20%	cbioportal
14	SPTA1	Ssm	21	110	19.1%	cbioportal
13	FAM135B	Ssm	21	110	19.1%	cbioportal
17	STK11	Ssm	20	110	18.2%	cbioportal
15	CSMD1	Ssm	20	110	18.2%	cbioportal
16	PCLO	Ssm	20	110	18.2%	cbioportal
18	APOB	Ssm	19	110	17.3%	cbioportal
19	EYS	Ssm	19	110	17.3%	cbioportal
20	MUC17	Ssm	19	110	17.3%	cbioportal
21	NRXN1	Ssm	19	110	17.3%	cbioportal
22	PCDH15	Ssm	19	110	17.3%	cbioportal
23	CNTNAP2	Ssm	18	110	16.4%	cbioportal
25	XIRP2	Ssm	18	110	16.4%	cbioportal
24	FLG	Ssm	18	110	16.4%	cbioportal
29	LRTM3	Ssm	17	110	15.5%	cbioportal
30	NAV3	Ssm	17	110	15.5%	cbioportal
26	ADAMTS12	Ssm	17	110	15.5%	cbioportal
27	ANK2	Ssm	17	110	15.5%	cbioportal
28	FBN2	Ssm	17	110	15.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Lung Adenocarcinoma (CPTAC GDC, 2025) luad_cptac_gdcCPTAC GDC

236 cases with simple somatic mutation data · 241 cases total · 2026-01-14 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	119	236	50.4%	cbioportal
2	RYR2	Ssm	80	236	33.9%	cbioportal
3	CSMD3	Ssm	76	236	32.2%	cbioportal
4	MUC16	Ssm	75	236	31.8%	cbioportal
5	EGFR	Ssm	70	236	29.7%	cbioportal
6	USH2A	Ssm	70	236	29.7%	cbioportal
7	KRAS	Ssm	69	236	29.2%	cbioportal
8	TTN	Ssm	68	236	28.8%	cbioportal
9	ZFHX4	Ssm	57	236	24.2%	cbioportal
10	LRP1B	Ssm	53	236	22.5%	cbioportal
11	XIRP2	Ssm	53	236	22.5%	cbioportal
12	CSMD1	Ssm	51	236	21.6%	cbioportal
13	FSIP2	Ssm	51	236	21.6%	cbioportal
15	SPTA1	Ssm	47	236	19.9%	cbioportal
14	LRTM3	Ssm	47	236	19.9%	cbioportal
16	FAT3	Ssm	45	236	19.1%	cbioportal
18	MUC17	Ssm	44	236	18.6%	cbioportal
17	EYS	Ssm	44	236	18.6%	cbioportal
19	PCLO	Ssm	42	236	17.8%	cbioportal
21	COL11A1	Ssm	41	236	17.4%	cbioportal
22	FLG	Ssm	41	236	17.4%	cbioportal
20	APOB	Ssm	41	236	17.4%	cbioportal
23	SYNE1	Ssm	40	236	16.9%	cbioportal
24	ZNF536	Ssm	40	236	16.9%	cbioportal
25	PCDH15	Ssm	38	236	16.1%	cbioportal
28	STK11	Ssm	37	236	15.7%	cbioportal
26	FAT4	Ssm	37	236	15.7%	cbioportal
27	NAV3	Ssm	37	236	15.7%	cbioportal
30	RYR3	Ssm	36	236	15.3%	cbioportal
29	ANK2	Ssm	36	236	15.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Lung Adenocarcinoma Met Organotropism (MSK, Cancer Cell 2023) luad_mskcc_2023_met_organotropismMSK

2,653 cases with simple somatic mutation data · 2,653 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	1,429	2,653	53.9%	cbioportal
59	TTN	Ssm	90	231	39%	cbioportal
65	RYR2	Ssm	85	231	36.8%	cbioportal
2	EGFR	Ssm	866	2,653	32.6%	cbioportal
82	MUC16	Ssm	72	231	31.2%	cbioportal
3	KRAS	Ssm	787	2,653	29.7%	cbioportal
90	CSMD3	Ssm	65	231	28.1%	cbioportal
94	LRP1B	Ssm	64	231	27.7%	cbioportal
102	USH2A	Ssm	61	231	26.4%	cbioportal
119	CSMD1	Ssm	54	231	23.4%	cbioportal
125	FSIP2	Ssm	52	231	22.5%	cbioportal
144	EYS	Ssm	45	231	19.5%	cbioportal
150	SPTA1	Ssm	43	231	18.6%	cbioportal
153	ZNF536	Ssm	43	231	18.6%	cbioportal
149	PCDH15	Ssm	43	231	18.6%	cbioportal
152	ZFHX4	Ssm	43	231	18.6%	cbioportal
154	ABCA13	Ssm	42	231	18.2%	cbioportal
164	CACNA1E	Ssm	41	231	17.7%	cbioportal
168	XIRP2	Ssm	41	231	17.7%	cbioportal
4	STK11	Ssm	450	2,653	17%	cbioportal
183	FAT3	Ssm	38	231	16.5%	cbioportal
182	ASXL3	Ssm	38	231	16.5%	cbioportal
186	RYR1	Ssm	38	231	16.5%	cbioportal
191	MUC17	Ssm	37	231	16%	cbioportal
189	COL11A1	Ssm	37	231	16%	cbioportal
198	PAPPA2	Ssm	36	231	15.6%	cbioportal
200	ANK2	Ssm	35	231	15.2%	cbioportal
5	KEAP1	Ssm	400	2,653	15.1%	cbioportal
6	RBM10	Ssm	294	2,653	11.1%	cbioportal
7	PTPRD	Ssm	270	2,653	10.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Adenocarcinoma (MSK, 2021) luad_mskimpact_2021MSK

186 cases with simple somatic mutation data · 186 cases total · 2026-04-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	EGFR	Ssm	183	186	98.4%	cbioportal
2	TP53	Ssm	128	186	68.8%	cbioportal
3	PIK3CA	Ssm	20	186	10.8%	cbioportal
4	RB1	Ssm	19	186	10.2%	cbioportal
5	CTNNB1	Ssm	18	186	9.7%	cbioportal
6	RBM10	Ssm	14	186	7.5%	cbioportal
7	PTEN	Ssm	13	186	7%	cbioportal
8	ARID1A	Ssm	10	186	5.4%	cbioportal
10	PTPRD	Ssm	9	186	4.8%	cbioportal
9	ATR	Ssm	9	186	4.8%	cbioportal
13	ZFHX3	Ssm	8	185	4.3%	cbioportal
12	KMT2C	Ssm	8	186	4.3%	cbioportal
11	APC	Ssm	8	186	4.3%	cbioportal
14	SMARCA4	Ssm	7	186	3.8%	cbioportal
16	FAT1	Ssm	6	186	3.2%	cbioportal
15	ASXL1	Ssm	6	186	3.2%	cbioportal
17	NOTCH4	Ssm	6	186	3.2%	cbioportal
18	TSC2	Ssm	6	186	3.2%	cbioportal
27	PLCG2	Ssm	5	185	2.7%	cbioportal
23	MGA	Ssm	5	185	2.7%	cbioportal
19	EPHA5	Ssm	5	186	2.7%	cbioportal
20	H1-2	Ssm	5	186	2.7%	cbioportal
21	KEAP1	Ssm	5	186	2.7%	cbioportal
22	MED12	Ssm	5	186	2.7%	cbioportal
24	MTOR	Ssm	5	186	2.7%	cbioportal
25	NBN	Ssm	5	186	2.7%	cbioportal
26	NOTCH2	Ssm	5	186	2.7%	cbioportal
28	PTPRT	Ssm	5	186	2.7%	cbioportal
29	TET1	Ssm	5	186	2.7%	cbioportal
35	CSF3R	Ssm	4	185	2.2%	cbioportal

Data updated 22 days agoSource updated 2026-04-07

Lung Adenocarcinoma (MSK, J Thorac Oncol 2020) luad_mskcc_2020MSK

604 cases with simple somatic mutation data · 604 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	230	604	38.1%	cbioportal
2	TP53	Ssm	219	604	36.3%	cbioportal
3	EGFR	Ssm	182	604	30.1%	cbioportal
4	RBM10	Ssm	97	604	16.1%	cbioportal
5	STK11	Ssm	90	604	14.9%	cbioportal
6	KEAP1	Ssm	68	604	11.3%	cbioportal
7	NF1	Ssm	48	604	7.9%	cbioportal
9	PTPRD	Ssm	47	604	7.8%	cbioportal
10	PTPRT	Ssm	47	604	7.8%	cbioportal
8	FAT1	Ssm	47	604	7.8%	cbioportal
11	ATM	Ssm	44	604	7.3%	cbioportal
12	SETD2	Ssm	43	604	7.1%	cbioportal
13	BRAF	Ssm	41	604	6.8%	cbioportal
14	MED12	Ssm	39	604	6.5%	cbioportal
15	EPHA3	Ssm	38	604	6.3%	cbioportal
16	PIK3CA	Ssm	35	604	5.8%	cbioportal
17	MET	Ssm	34	604	5.6%	cbioportal
18	NTRK3	Ssm	34	604	5.6%	cbioportal
19	MGA	Ssm	33	596	5.5%	cbioportal
20	SMARCA4	Ssm	33	604	5.5%	cbioportal
23	EPHA5	Ssm	30	604	5%	cbioportal
22	ATRX	Ssm	30	604	5%	cbioportal
21	ARID2	Ssm	30	604	5%	cbioportal
24	ERBB4	Ssm	29	604	4.8%	cbioportal
25	KMT2D	Ssm	28	604	4.6%	cbioportal
29	TERT	Ssm	27	604	4.5%	cbioportal
26	CDKN2A	Ssm	27	604	4.5%	cbioportal
28	GRIN2A	Ssm	27	604	4.5%	cbioportal
27	ERBB2	Ssm	27	604	4.5%	cbioportal
32	NOTCH4	Ssm	26	604	4.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Adenocarcinoma (MSK, NPJ Precision Oncology 2021) luad_msk_npjpo_2021MSK

426 cases with simple somatic mutation data · 426 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	155	426	36.4%	cbioportal
2	KRAS	Ssm	147	426	34.5%	cbioportal
3	EGFR	Ssm	139	426	32.6%	cbioportal
4	RBM10	Ssm	81	426	19%	cbioportal
5	STK11	Ssm	66	426	15.5%	cbioportal
6	KEAP1	Ssm	46	426	10.8%	cbioportal
7	FAT1	Ssm	36	426	8.5%	cbioportal
8	NF1	Ssm	35	426	8.2%	cbioportal
9	PTPRD	Ssm	34	426	8%	cbioportal
10	SETD2	Ssm	34	426	8%	cbioportal
11	PTPRT	Ssm	32	426	7.5%	cbioportal
12	ATM	Ssm	30	426	7%	cbioportal
13	BRAF	Ssm	29	426	6.8%	cbioportal
14	SMARCA4	Ssm	29	426	6.8%	cbioportal
15	KMT2D	Ssm	28	426	6.6%	cbioportal
16	MED12	Ssm	28	426	6.6%	cbioportal
21	MGA	Ssm	24	418	5.7%	cbioportal
20	MET	Ssm	24	426	5.6%	cbioportal
22	NTRK3	Ssm	24	426	5.6%	cbioportal
17	EPHA3	Ssm	24	426	5.6%	cbioportal
19	KMT2C	Ssm	24	426	5.6%	cbioportal
18	GRIN2A	Ssm	24	426	5.6%	cbioportal
23	ARID2	Ssm	23	426	5.4%	cbioportal
27	PIK3CA	Ssm	22	426	5.2%	cbioportal
25	ERBB4	Ssm	22	426	5.2%	cbioportal
24	EPHA5	Ssm	22	426	5.2%	cbioportal
26	PIK3C2G	Ssm	22	426	5.2%	cbioportal
29	NOTCH4	Ssm	21	426	4.9%	cbioportal
28	FLT1	Ssm	21	426	4.9%	cbioportal
30	TERT	Ssm	20	426	4.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Adenocarcinoma (MSK, Science 2015) luad_mskcc_2015MSK

35 cases with simple somatic mutation data · 35 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4	Ssm	19	35	54.3%	cbioportal
2	TP53	Ssm	16	35	45.7%	cbioportal
3	MUC16	Ssm	13	35	37.1%	cbioportal
4	CSMD3	Ssm	11	35	31.4%	cbioportal
5	LRP1B	Ssm	11	35	31.4%	cbioportal
6	TTN	Ssm	11	35	31.4%	cbioportal
7	HRNR	Ssm	10	35	28.6%	cbioportal
8	OBSCN	Ssm	10	35	28.6%	cbioportal
9	RYR2	Ssm	10	35	28.6%	cbioportal
10	ZFHX4	Ssm	10	35	28.6%	cbioportal
11	FLG	Ssm	9	35	25.7%	cbioportal
12	FLNC	Ssm	9	35	25.7%	cbioportal
13	TNRC18	Ssm	9	35	25.7%	cbioportal
14	CROCC	Ssm	8	35	22.9%	cbioportal
15	KRAS	Ssm	8	35	22.9%	cbioportal
16	CACNA1A	Ssm	7	35	20%	cbioportal
17	CRB2	Ssm	7	35	20%	cbioportal
18	CSMD1	Ssm	7	35	20%	cbioportal
19	MUC5B	Ssm	7	35	20%	cbioportal
20	PCDH15	Ssm	7	35	20%	cbioportal
28	MROH2B	Ssm	6	35	17.1%	cbioportal
21	ANK2	Ssm	6	35	17.1%	cbioportal
22	APOB	Ssm	6	35	17.1%	cbioportal
23	CDH10	Ssm	6	35	17.1%	cbioportal
24	CSMD2	Ssm	6	35	17.1%	cbioportal
25	DNAH11	Ssm	6	35	17.1%	cbioportal
26	FBN2	Ssm	6	35	17.1%	cbioportal
27	JAG2	Ssm	6	35	17.1%	cbioportal
29	MUC17	Ssm	6	35	17.1%	cbioportal
30	NPHP4	Ssm	6	35	17.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Adenocarcinoma (OncoSG, Nat Genet 2020) luad_oncosg_2020OncoSG

302 cases with simple somatic mutation data · 305 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	EGFR	Ssm	143	302	47.4%	cbioportal
2	TP53	Ssm	109	302	36.1%	cbioportal
3	TTN	Ssm	68	302	22.5%	cbioportal
5	USH2A	Ssm	50	302	16.6%	cbioportal
4	RYR2	Ssm	50	302	16.6%	cbioportal
6	MUC16	Ssm	46	302	15.2%	cbioportal
7	CSMD3	Ssm	43	302	14.2%	cbioportal
8	ZFHX4	Ssm	39	302	12.9%	cbioportal
9	FLG	Ssm	37	302	12.3%	cbioportal
10	LRP1B	Ssm	35	302	11.6%	cbioportal
11	KRAS	Ssm	33	302	10.9%	cbioportal
14	XIRP2	Ssm	30	302	9.9%	cbioportal
12	PCLO	Ssm	30	302	9.9%	cbioportal
13	SPTA1	Ssm	30	302	9.9%	cbioportal
15	ANK2	Ssm	29	302	9.6%	cbioportal
16	SI	Ssm	27	302	8.9%	cbioportal
18	FAT3	Ssm	26	302	8.6%	cbioportal
19	MUC17	Ssm	26	302	8.6%	cbioportal
17	CTNND2	Ssm	26	302	8.6%	cbioportal
22	CSMD1	Ssm	24	302	7.9%	cbioportal
21	COL11A1	Ssm	24	302	7.9%	cbioportal
20	AHNAK2	Ssm	24	302	7.9%	cbioportal
24	PRDM9	Ssm	24	302	7.9%	cbioportal
23	FAT4	Ssm	24	302	7.9%	cbioportal
28	ZNF536	Ssm	23	302	7.6%	cbioportal
27	NEB	Ssm	23	302	7.6%	cbioportal
26	NAV3	Ssm	23	302	7.6%	cbioportal
25	MUC4	Ssm	23	302	7.6%	cbioportal
29	RBM10	Ssm	22	302	7.3%	cbioportal
30	ADAMTS12	Ssm	21	302	7%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Adenocarcinoma (TCGA, Firehose Legacy) luad_tcgaTCGA

230 cases with simple somatic mutation data · 586 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	108	230	47%	cbioportal
2	TP53	Ssm	106	230	46.1%	cbioportal
3	MUC16	Ssm	91	230	39.6%	cbioportal
4	RYR2	Ssm	82	230	35.7%	cbioportal
5	KRAS	Ssm	75	230	32.6%	cbioportal
6	LRP1B	Ssm	68	230	29.6%	cbioportal
7	USH2A	Ssm	68	230	29.6%	cbioportal
8	ZFHX4	Ssm	63	230	27.4%	cbioportal
9	FLG	Ssm	62	230	27%	cbioportal
10	SPTA1	Ssm	58	230	25.2%	cbioportal
11	MUC17	Ssm	48	230	20.9%	cbioportal
12	XIRP2	Ssm	47	230	20.4%	cbioportal
13	PCLO	Ssm	46	230	20%	cbioportal
14	NAV3	Ssm	45	230	19.6%	cbioportal
15	CSMD1	Ssm	44	230	19.1%	cbioportal
16	FAT3	Ssm	44	230	19.1%	cbioportal
19	ZNF536	Ssm	42	230	18.3%	cbioportal
18	PCDH15	Ssm	42	230	18.3%	cbioportal
17	KMT2C	Ssm	42	230	18.3%	cbioportal
22	STK11	Ssm	40	230	17.4%	cbioportal
20	COL11A1	Ssm	40	230	17.4%	cbioportal
21	KEAP1	Ssm	40	230	17.4%	cbioportal
25	RP1L1	Ssm	39	230	17%	cbioportal
23	ADGRG4	Ssm	39	230	17%	cbioportal
24	PAPPA2	Ssm	39	230	17%	cbioportal
29	ZNF804A	Ssm	38	230	16.5%	cbioportal
26	ADAMTS12	Ssm	38	230	16.5%	cbioportal
27	AHNAK2	Ssm	38	230	16.5%	cbioportal
28	APOB	Ssm	38	230	16.5%	cbioportal
30	DNAH9	Ssm	37	230	16.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Adenocarcinoma (TCGA GDC, 2025) luad_tcga_gdcTCGA GDC

559 cases with simple somatic mutation data · 571 cases total · 2026-01-13 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	284	559	50.8%	cbioportal
2	TTN	Ssm	245	559	43.8%	cbioportal
3	MUC16	Ssm	225	559	40.3%	cbioportal
4	CSMD3	Ssm	213	559	38.1%	cbioportal
5	RYR2	Ssm	200	559	35.8%	cbioportal
6	LRP1B	Ssm	184	559	32.9%	cbioportal
7	ZFHX4	Ssm	172	559	30.8%	cbioportal
8	USH2A	Ssm	168	559	30.1%	cbioportal
9	KRAS	Ssm	149	559	26.7%	cbioportal
10	XIRP2	Ssm	134	559	24%	cbioportal
11	FLG	Ssm	129	559	23.1%	cbioportal
12	SPTA1	Ssm	124	559	22.2%	cbioportal
13	NAV3	Ssm	117	559	20.9%	cbioportal
14	COL11A1	Ssm	114	559	20.4%	cbioportal
15	ZNF536	Ssm	112	559	20%	cbioportal
16	FAT3	Ssm	107	559	19.1%	cbioportal
17	ANK2	Ssm	106	559	19%	cbioportal
18	CSMD1	Ssm	103	559	18.4%	cbioportal
19	PCLO	Ssm	103	559	18.4%	cbioportal
20	APOB	Ssm	101	559	18.1%	cbioportal
21	PCDH15	Ssm	101	559	18.1%	cbioportal
22	KEAP1	Ssm	98	559	17.5%	cbioportal
24	MUC17	Ssm	97	559	17.4%	cbioportal
23	ADAMTS12	Ssm	97	559	17.4%	cbioportal
25	TNR	Ssm	95	559	17%	cbioportal
26	DNAH9	Ssm	93	559	16.6%	cbioportal
27	PAPPA2	Ssm	90	559	16.1%	cbioportal
28	RP1L1	Ssm	90	559	16.1%	cbioportal
29	ADGRG4	Ssm	89	559	15.9%	cbioportal
30	RYR3	Ssm	89	559	15.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Lung Adenocarcinoma (TCGA, Nature 2014) luad_tcga_pubTCGA

230 cases with simple somatic mutation data · 230 cases total · 2026-01-19 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	108	230	47%	cbioportal
2	TP53	Ssm	107	230	46.5%	cbioportal
3	MUC16	Ssm	91	230	39.6%	cbioportal
4	RYR2	Ssm	82	230	35.7%	cbioportal
5	CSMD3	Ssm	81	230	35.2%	cbioportal
6	KRAS	Ssm	75	230	32.6%	cbioportal
7	LRP1B	Ssm	68	230	29.6%	cbioportal
8	USH2A	Ssm	68	230	29.6%	cbioportal
9	ZFHX4	Ssm	63	230	27.4%	cbioportal
10	FLG	Ssm	62	230	27%	cbioportal
11	SPTA1	Ssm	58	230	25.2%	cbioportal
12	MUC17	Ssm	48	230	20.9%	cbioportal
13	XIRP2	Ssm	47	230	20.4%	cbioportal
14	PCLO	Ssm	46	230	20%	cbioportal
15	NAV3	Ssm	45	230	19.6%	cbioportal
17	FAT3	Ssm	44	230	19.1%	cbioportal
16	CSMD1	Ssm	44	230	19.1%	cbioportal
18	KMT2C	Ssm	43	230	18.7%	cbioportal
20	ZNF536	Ssm	42	230	18.3%	cbioportal
19	PCDH15	Ssm	42	230	18.3%	cbioportal
22	KEAP1	Ssm	40	230	17.4%	cbioportal
21	COL11A1	Ssm	40	230	17.4%	cbioportal
23	STK11	Ssm	40	230	17.4%	cbioportal
26	RP1L1	Ssm	39	230	17%	cbioportal
24	ADGRG4	Ssm	39	230	17%	cbioportal
25	PAPPA2	Ssm	39	230	17%	cbioportal
30	ZNF804A	Ssm	38	230	16.5%	cbioportal
27	ADAMTS12	Ssm	38	230	16.5%	cbioportal
28	AHNAK2	Ssm	38	230	16.5%	cbioportal
29	APOB	Ssm	38	230	16.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Lung Adenocarcinoma (TCGA, PanCancer Atlas) luad_tcga_pan_can_atlas_2018TCGA

566 cases with simple somatic mutation data · 566 cases total · 2026-06-04 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	295	566	52.1%	cbioportal
2	TTN	Ssm	272	566	48.1%	cbioportal
3	MUC16	Ssm	242	566	42.8%	cbioportal
4	CSMD3	Ssm	226	566	39.9%	cbioportal
5	RYR2	Ssm	217	566	38.3%	cbioportal
6	LRP1B	Ssm	201	566	35.5%	cbioportal
7	ZFHX4	Ssm	185	566	32.7%	cbioportal
8	USH2A	Ssm	177	566	31.3%	cbioportal
9	KRAS	Ssm	168	566	29.7%	cbioportal
10	XIRP2	Ssm	150	566	26.5%	cbioportal
11	SPTA1	Ssm	148	566	26.1%	cbioportal
12	FLG	Ssm	145	566	25.6%	cbioportal
13	CSMD1	Ssm	125	566	22.1%	cbioportal
14	NAV3	Ssm	123	566	21.7%	cbioportal
15	FAT3	Ssm	121	566	21.4%	cbioportal
16	COL11A1	Ssm	120	566	21.2%	cbioportal
17	PCDH15	Ssm	118	566	20.8%	cbioportal
18	ZNF536	Ssm	117	566	20.7%	cbioportal
19	ANK2	Ssm	111	566	19.6%	cbioportal
20	MUC17	Ssm	111	566	19.6%	cbioportal
21	PCLO	Ssm	109	566	19.3%	cbioportal
22	RYR3	Ssm	106	566	18.7%	cbioportal
23	APOB	Ssm	104	566	18.4%	cbioportal
24	KEAP1	Ssm	102	566	18%	cbioportal
25	PAPPA2	Ssm	101	566	17.8%	cbioportal
26	ADAMTS12	Ssm	99	566	17.5%	cbioportal
27	DNAH9	Ssm	99	566	17.5%	cbioportal
28	ADGRG4	Ssm	98	566	17.3%	cbioportal
29	RP1L1	Ssm	97	566	17.1%	cbioportal
30	RYR1	Ssm	95	566	16.8%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Lung Adenocarcinoma (TSP, Nature 2008) luad_tspTSP

163 cases with simple somatic mutation data · 163 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	64	163	39.3%	cbioportal
2	KRAS	Ssm	60	163	36.8%	cbioportal
3	STK11	Ssm	34	163	20.9%	cbioportal
4	EGFR	Ssm	30	163	18.4%	cbioportal
5	LRP1B	Ssm	16	163	9.8%	cbioportal
6	ATM	Ssm	13	163	8%	cbioportal
7	NF1	Ssm	13	163	8%	cbioportal
8	APC	Ssm	11	163	6.7%	cbioportal
9	EPHA3	Ssm	10	163	6.1%	cbioportal
10	CDKN2A	Ssm	9	163	5.5%	cbioportal
11	PTPRD	Ssm	9	163	5.5%	cbioportal
13	KDR	Ssm	8	163	4.9%	cbioportal
12	ERBB4	Ssm	8	163	4.9%	cbioportal
19	PRKDC	Ssm	7	163	4.3%	cbioportal
20	RB1	Ssm	7	163	4.3%	cbioportal
18	NTRK3	Ssm	7	163	4.3%	cbioportal
17	NTRK1	Ssm	7	163	4.3%	cbioportal
16	MYO3B	Ssm	7	163	4.3%	cbioportal
15	FGFR4	Ssm	7	163	4.3%	cbioportal
14	EPHA5	Ssm	7	163	4.3%	cbioportal
23	LTK	Ssm	6	163	3.7%	cbioportal
22	INSRR	Ssm	6	163	3.7%	cbioportal
21	EPHA7	Ssm	6	163	3.7%	cbioportal
25	PDGFRA	Ssm	6	163	3.7%	cbioportal
24	NTRK2	Ssm	6	163	3.7%	cbioportal
28	EPHB6	Ssm	5	163	3.1%	cbioportal
26	CDC42BPA	Ssm	5	163	3.1%	cbioportal
30	JAK2	Ssm	5	163	3.1%	cbioportal
29	INHBA	Ssm	5	163	3.1%	cbioportal
27	DOCK3	Ssm	5	163	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Cancer in Never Smokers (NCI, Nature Genetics 2021) lung_nci_2022NCI

232 cases with simple somatic mutation data · 232 cases total · 2026-01-16 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	EGFR	Ssm	66	232	28.4%	cbioportal
2	TP53	Ssm	36	232	15.5%	cbioportal
3	TTN	Ssm	21	232	9.1%	cbioportal
4	KRAS	Ssm	17	232	7.3%	cbioportal
5	RBM10	Ssm	17	232	7.3%	cbioportal
6	MUC16	Ssm	12	232	5.2%	cbioportal
8	PIK3CA	Ssm	10	232	4.3%	cbioportal
7	LRRK2	Ssm	10	232	4.3%	cbioportal
9	SETD2	Ssm	10	232	4.3%	cbioportal
10	ERBB2	Ssm	9	232	3.9%	cbioportal
16	ZFHX4	Ssm	9	232	3.9%	cbioportal
15	XIRP2	Ssm	9	232	3.9%	cbioportal
14	UBA1	Ssm	9	232	3.9%	cbioportal
13	RYR2	Ssm	9	232	3.9%	cbioportal
12	REV3L	Ssm	9	232	3.9%	cbioportal
11	HUWE1	Ssm	9	232	3.9%	cbioportal
18	CSMD1	Ssm	8	232	3.4%	cbioportal
17	BIRC6	Ssm	8	232	3.4%	cbioportal
20	LRP1B	Ssm	8	232	3.4%	cbioportal
19	CSMD3	Ssm	8	232	3.4%	cbioportal
21	AR	Ssm	7	232	3%	cbioportal
25	FBN2	Ssm	7	232	3%	cbioportal
26	FSIP2	Ssm	7	232	3%	cbioportal
27	GLUD2	Ssm	7	232	3%	cbioportal
28	MET	Ssm	7	232	3%	cbioportal
22	ARID1A	Ssm	7	232	3%	cbioportal
23	ARID2	Ssm	7	232	3%	cbioportal
24	DNAH5	Ssm	7	232	3%	cbioportal
30	ADGRV1	Ssm	6	232	2.6%	cbioportal
29	ADGRG4	Ssm	6	232	2.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Lung Squamous Cell Carcinoma TCGA-LUSCTCGA

504 cases with simple somatic mutation data · 504 cases total · Data Release 46.0 · mapped to Lung Squamous Cell Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	453	504	89.9%	gdc
2	DVL3	Ssm	444	504	88.1%	gdc
8	EPHB3	Ssm	444	504	88.1%	gdc
7	CCDC39	Ssm	444	504	88.1%	gdc
6	ATP11B	Ssm	444	504	88.1%	gdc
5	EEF1AKMT4-ECE2	Ssm	444	504	88.1%	gdc
4	ABCC5	Ssm	444	504	88.1%	gdc
3	KLHL6	Ssm	444	504	88.1%	gdc
19	ABCF3	Ssm	443	504	87.9%	gdc
18	TNIK	Ssm	443	504	87.9%	gdc
17	ZBBX	Ssm	443	504	87.9%	gdc
16	MAGEF1	Ssm	443	504	87.9%	gdc
15	AC131160.1	Ssm	443	504	87.9%	gdc
14	PARL	Ssm	443	504	87.9%	gdc
13	SOX2	Ssm	443	504	87.9%	gdc
12	MECOM	Ssm	443	504	87.9%	gdc
11	HTR3C	Ssm	443	504	87.9%	gdc
10	ACTRT3	Ssm	443	504	87.9%	gdc
9	HTR3E	Ssm	443	504	87.9%	gdc
26	FNDC3B	Ssm	443	504	87.9%	gdc
25	VPS8	Ssm	443	504	87.9%	gdc
24	EIF2B5	Ssm	443	504	87.9%	gdc
23	CHRD	Ssm	443	504	87.9%	gdc
22	MAP6D1	Ssm	443	504	87.9%	gdc
21	DCUN1D1	Ssm	443	504	87.9%	gdc
20	CLCN2	Ssm	443	504	87.9%	gdc
27	LAMP3	Ssm	442	504	87.7%	gdc
29	SAMD7	Ssm	442	504	87.7%	gdc
30	EIF4G1	Ssm	442	504	87.7%	gdc
28	USP13	Ssm	442	504	87.7%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Lung Squamous Cell Carcinoma (CPTAC, Cell 2021) lusc_cptac_2021CPTAC

108 cases with simple somatic mutation data · 80 cases total · 2026-01-16 · mapped to Lung Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	102	108	94.4%	cbioportal
2	TTN	Ssm	74	108	68.5%	cbioportal
3	CSMD3	Ssm	51	108	47.2%	cbioportal
4	USH2A	Ssm	43	108	39.8%	cbioportal
5	RYR2	Ssm	40	108	37%	cbioportal
6	ZFHX4	Ssm	40	108	37%	cbioportal
7	LRP1B	Ssm	34	108	31.5%	cbioportal
8	SYNE1	Ssm	34	108	31.5%	cbioportal
9	FAM135B	Ssm	33	108	30.6%	cbioportal
10	MUC16	Ssm	33	108	30.6%	cbioportal
11	DNAH5	Ssm	26	108	24.1%	cbioportal
12	KMT2D	Ssm	26	108	24.1%	cbioportal
13	PCDH15	Ssm	25	108	23.1%	cbioportal
14	COL22A1	Ssm	23	108	21.3%	cbioportal
15	COL11A1	Ssm	22	108	20.4%	cbioportal
16	FSIP2	Ssm	22	108	20.4%	cbioportal
18	CDH10	Ssm	21	108	19.4%	cbioportal
19	FAT3	Ssm	21	108	19.4%	cbioportal
21	RYR3	Ssm	21	108	19.4%	cbioportal
20	OBSCN	Ssm	21	108	19.4%	cbioportal
22	XIRP2	Ssm	21	108	19.4%	cbioportal
17	ADAMTS12	Ssm	21	108	19.4%	cbioportal
26	NAV3	Ssm	20	108	18.5%	cbioportal
28	UNC80	Ssm	20	108	18.5%	cbioportal
23	CSMD2	Ssm	20	108	18.5%	cbioportal
24	EYS	Ssm	20	108	18.5%	cbioportal
25	FLG	Ssm	20	108	18.5%	cbioportal
27	PCLO	Ssm	20	108	18.5%	cbioportal
30	ERICH3	Ssm	19	108	17.6%	cbioportal
29	CUBN	Ssm	19	108	17.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Lung Squamous Cell Carcinoma (CPTAC GDC, 2025) lusc_cptac_gdcCPTAC GDC

110 cases with simple somatic mutation data · 110 cases total · 2026-01-14 · mapped to Lung Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	101	110	91.8%	cbioportal
2	TTN	Ssm	72	110	65.5%	cbioportal
3	CSMD3	Ssm	42	110	38.2%	cbioportal
4	USH2A	Ssm	42	110	38.2%	cbioportal
5	RYR2	Ssm	39	110	35.5%	cbioportal
6	ZFHX4	Ssm	34	110	30.9%	cbioportal
7	MUC16	Ssm	33	110	30%	cbioportal
8	SYNE1	Ssm	32	110	29.1%	cbioportal
9	LRP1B	Ssm	31	110	28.2%	cbioportal
10	FAM135B	Ssm	28	110	25.5%	cbioportal
11	KMT2D	Ssm	26	110	23.6%	cbioportal
12	DNAH5	Ssm	24	110	21.8%	cbioportal
13	FSIP2	Ssm	24	110	21.8%	cbioportal
14	COL22A1	Ssm	22	110	20%	cbioportal
15	COL11A1	Ssm	21	110	19.1%	cbioportal
16	PCLO	Ssm	21	110	19.1%	cbioportal
17	LRTM3	Ssm	20	110	18.2%	cbioportal
18	MUC19	Ssm	20	110	18.2%	cbioportal
24	RYR3	Ssm	19	110	17.3%	cbioportal
23	PRDM9	Ssm	19	110	17.3%	cbioportal
22	PCDH15	Ssm	19	110	17.3%	cbioportal
21	EYS	Ssm	19	110	17.3%	cbioportal
20	CTNND2	Ssm	19	110	17.3%	cbioportal
19	CDH10	Ssm	19	110	17.3%	cbioportal
25	XIRP2	Ssm	19	110	17.3%	cbioportal
28	CUBN	Ssm	18	110	16.4%	cbioportal
27	CDKN2A	Ssm	18	110	16.4%	cbioportal
26	ADAMTS12	Ssm	18	110	16.4%	cbioportal
29	NAV3	Ssm	18	110	16.4%	cbioportal
30	PKHD1L1	Ssm	18	110	16.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Lung Squamous Cell Carcinoma (TCGA, Firehose Legacy) lusc_tcgaTCGA

178 cases with simple somatic mutation data · 511 cases total · 2026-01-07 · mapped to Lung Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	145	178	81.5%	cbioportal
2	TTN	Ssm	126	178	70.8%	cbioportal
4	RYR2	Ssm	77	178	43.3%	cbioportal
3	MUC16	Ssm	77	178	43.3%	cbioportal
5	LRP1B	Ssm	69	178	38.8%	cbioportal
6	USH2A	Ssm	68	178	38.2%	cbioportal
7	ZFHX4	Ssm	65	178	36.5%	cbioportal
8	ADAM6	Ssm	53	178	29.8%	cbioportal
9	SYNE1	Ssm	52	178	29.2%	cbioportal
10	RYR3	Ssm	42	178	23.6%	cbioportal
11	SPTA1	Ssm	40	178	22.5%	cbioportal
12	DNAH11	Ssm	39	178	21.9%	cbioportal
13	FAM135B	Ssm	37	178	20.8%	cbioportal
14	KMT2D	Ssm	37	178	20.8%	cbioportal
15	PKHD1	Ssm	37	178	20.8%	cbioportal
16	COL11A1	Ssm	36	178	20.2%	cbioportal
17	FLG	Ssm	36	178	20.2%	cbioportal
18	PKHD1L1	Ssm	36	178	20.2%	cbioportal
19	SI	Ssm	36	178	20.2%	cbioportal
21	MUC5B	Ssm	34	178	19.1%	cbioportal
22	NAV3	Ssm	34	178	19.1%	cbioportal
20	ERICH3	Ssm	34	178	19.1%	cbioportal
24	LRP2	Ssm	33	178	18.5%	cbioportal
25	TENM1	Ssm	33	178	18.5%	cbioportal
26	XIRP2	Ssm	33	178	18.5%	cbioportal
27	ZNF536	Ssm	33	178	18.5%	cbioportal
23	CUBN	Ssm	33	178	18.5%	cbioportal
28	CSMD1	Ssm	32	178	18%	cbioportal
30	CDH10	Ssm	31	178	17.4%	cbioportal
29	ADGRV1	Ssm	31	178	17.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Squamous Cell Carcinoma (TCGA GDC, 2025) lusc_tcga_gdcTCGA GDC

484 cases with simple somatic mutation data · 503 cases total · 2026-01-13 · mapped to Lung Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	408	484	84.3%	cbioportal
2	TTN	Ssm	340	484	70.2%	cbioportal
3	CSMD3	Ssm	205	484	42.4%	cbioportal
4	MUC16	Ssm	187	484	38.6%	cbioportal
5	RYR2	Ssm	179	484	37%	cbioportal
6	LRP1B	Ssm	160	484	33.1%	cbioportal
7	USH2A	Ssm	156	484	32.2%	cbioportal
8	SYNE1	Ssm	148	484	30.6%	cbioportal
9	ZFHX4	Ssm	142	484	29.3%	cbioportal
10	FAM135B	Ssm	112	484	23.1%	cbioportal
11	KMT2D	Ssm	105	484	21.7%	cbioportal
12	NAV3	Ssm	101	484	20.9%	cbioportal
13	XIRP2	Ssm	95	484	19.6%	cbioportal
14	CDH10	Ssm	93	484	19.2%	cbioportal
15	RYR3	Ssm	93	484	19.2%	cbioportal
16	SPTA1	Ssm	93	484	19.2%	cbioportal
17	PKHD1	Ssm	90	484	18.6%	cbioportal
18	PCDH15	Ssm	89	484	18.4%	cbioportal
19	PCLO	Ssm	87	484	18%	cbioportal
20	PAPPA2	Ssm	86	484	17.8%	cbioportal
21	DNAH5	Ssm	84	484	17.4%	cbioportal
22	DNAH8	Ssm	84	484	17.4%	cbioportal
23	PKHD1L1	Ssm	83	484	17.1%	cbioportal
24	MUC17	Ssm	80	484	16.5%	cbioportal
25	FLG	Ssm	79	484	16.3%	cbioportal
27	HCN1	Ssm	78	484	16.1%	cbioportal
26	ADAMTS12	Ssm	78	484	16.1%	cbioportal
29	SI	Ssm	77	484	15.9%	cbioportal
28	ERICH3	Ssm	77	484	15.9%	cbioportal
30	COL11A1	Ssm	76	484	15.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Lung Squamous Cell Carcinoma (TCGA, Nature 2012) lusc_tcga_pubTCGA

178 cases with simple somatic mutation data · 178 cases total · 2026-02-19 · mapped to Lung Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	149	178	83.7%	cbioportal
2	TTN	Ssm	129	178	72.5%	cbioportal
3	CSMD3	Ssm	80	178	44.9%	cbioportal
4	RYR2	Ssm	78	178	43.8%	cbioportal
5	MUC16	Ssm	74	178	41.6%	cbioportal
7	ZFHX4	Ssm	68	178	38.2%	cbioportal
6	LRP1B	Ssm	68	178	38.2%	cbioportal
8	USH2A	Ssm	67	178	37.6%	cbioportal
9	SYNE1	Ssm	52	178	29.2%	cbioportal
10	RYR3	Ssm	49	178	27.5%	cbioportal
11	DNAH11	Ssm	40	178	22.5%	cbioportal
12	FLG	Ssm	40	178	22.5%	cbioportal
14	PKHD1	Ssm	39	178	21.9%	cbioportal
13	FAM135B	Ssm	39	178	21.9%	cbioportal
15	SPTA1	Ssm	39	178	21.9%	cbioportal
16	PKHD1L1	Ssm	38	178	21.3%	cbioportal
17	KMT2D	Ssm	37	178	20.8%	cbioportal
18	SI	Ssm	37	178	20.8%	cbioportal
19	COL11A1	Ssm	36	178	20.2%	cbioportal
20	NAV3	Ssm	36	178	20.2%	cbioportal
21	LRP2	Ssm	35	178	19.7%	cbioportal
22	XIRP2	Ssm	35	178	19.7%	cbioportal
23	ERICH3	Ssm	34	178	19.1%	cbioportal
25	MUC17	Ssm	34	178	19.1%	cbioportal
24	HCN1	Ssm	34	178	19.1%	cbioportal
28	CSMD1	Ssm	33	178	18.5%	cbioportal
26	AHNAK2	Ssm	33	178	18.5%	cbioportal
27	CDH10	Ssm	33	178	18.5%	cbioportal
30	DNAH5	Ssm	33	178	18.5%	cbioportal
29	CUBN	Ssm	33	178	18.5%	cbioportal

Data updated 22 days agoSource updated 2026-02-19

Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) lusc_tcga_pan_can_atlas_2018TCGA

484 cases with simple somatic mutation data · 487 cases total · 2026-06-04 · mapped to Lung Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	404	484	83.5%	cbioportal
2	TTN	Ssm	345	484	71.3%	cbioportal
3	CSMD3	Ssm	209	484	43.2%	cbioportal
4	RYR2	Ssm	192	484	39.7%	cbioportal
5	MUC16	Ssm	188	484	38.8%	cbioportal
6	LRP1B	Ssm	171	484	35.3%	cbioportal
7	USH2A	Ssm	160	484	33.1%	cbioportal
8	SYNE1	Ssm	151	484	31.2%	cbioportal
9	ZFHX4	Ssm	143	484	29.5%	cbioportal
10	FAM135B	Ssm	118	484	24.4%	cbioportal
11	KMT2D	Ssm	111	484	22.9%	cbioportal
12	NAV3	Ssm	104	484	21.5%	cbioportal
13	RYR3	Ssm	99	484	20.5%	cbioportal
14	CDH10	Ssm	97	484	20%	cbioportal
15	SPTA1	Ssm	97	484	20%	cbioportal
18	XIRP2	Ssm	93	484	19.2%	cbioportal
16	DNAH5	Ssm	93	484	19.2%	cbioportal
17	PCDH15	Ssm	93	484	19.2%	cbioportal
19	PKHD1L1	Ssm	91	484	18.8%	cbioportal
20	PAPPA2	Ssm	89	484	18.4%	cbioportal
21	PCLO	Ssm	88	484	18.2%	cbioportal
22	PKHD1	Ssm	87	484	18%	cbioportal
23	COL11A1	Ssm	84	484	17.4%	cbioportal
24	ERICH3	Ssm	84	484	17.4%	cbioportal
26	SI	Ssm	84	484	17.4%	cbioportal
25	FLG	Ssm	84	484	17.4%	cbioportal
27	COL22A1	Ssm	83	484	17.1%	cbioportal
29	RYR1	Ssm	83	484	17.1%	cbioportal
28	DNAH8	Ssm	83	484	17.1%	cbioportal
30	CSMD1	Ssm	82	484	16.9%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Metastatic Non-Small Cell Lung Cancer (MSK, Nature Medicine 2022) nsclc_ctdx_msk_2022MSK

2,621 cases with simple somatic mutation data · 2,621 cases total · 2026-01-08 · mapped to Lung Non-Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	1,123	2,621	42.8%	cbioportal
2	EGFR	Ssm	662	2,621	25.3%	cbioportal
3	KRAS	Ssm	523	2,621	20%	cbioportal
4	STK11	Ssm	222	2,621	8.5%	cbioportal
11	RBM10	Ssm	75	945	7.9%	cbioportal
5	KEAP1	Ssm	197	2,621	7.5%	cbioportal
13	PTPRD	Ssm	70	945	7.4%	cbioportal
10	PTEN	Ssm	77	1,257	6.1%	cbioportal
12	ATM	Ssm	71	1,257	5.6%	cbioportal
23	ZFHX3	Ssm	52	940	5.5%	cbioportal
14	APC	Ssm	69	1,257	5.5%	cbioportal
15	ARID1A	Ssm	68	1,257	5.4%	cbioportal
24	FAT1	Ssm	51	954	5.3%	cbioportal
16	SMARCA4	Ssm	67	1,257	5.3%	cbioportal
26	PTPRT	Ssm	50	945	5.3%	cbioportal
25	MGA	Ssm	50	949	5.3%	cbioportal
17	NF1	Ssm	66	1,257	5.3%	cbioportal
6	MET	Ssm	134	2,621	5.1%	cbioportal
27	KMT2D	Ssm	48	954	5%	cbioportal
19	CDKN2A	Ssm	63	1,257	5%	cbioportal
20	CTNNB1	Ssm	62	1,257	4.9%	cbioportal
21	RB1	Ssm	59	1,257	4.7%	cbioportal
22	SMAD4	Ssm	58	1,257	4.6%	cbioportal
32	GRIN2A	Ssm	40	954	4.2%	cbioportal
33	KMT2C	Ssm	38	954	4%	cbioportal
7	ERBB2	Ssm	103	2,621	3.9%	cbioportal
35	EPHA3	Ssm	37	954	3.9%	cbioportal
8	PIK3CA	Ssm	101	2,621	3.9%	cbioportal
39	ARID1B	Ssm	35	954	3.7%	cbioportal
40	ATR	Ssm	35	954	3.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Non-Small Cell Cancer (MSK, Cancer Discov 2017) lung_msk_2017MSK

915 cases with simple somatic mutation data · 915 cases total · 2026-04-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	485	915	53%	cbioportal
2	EGFR	Ssm	268	915	29.3%	cbioportal
3	KRAS	Ssm	241	915	26.3%	cbioportal
4	STK11	Ssm	157	915	17.2%	cbioportal
5	KEAP1	Ssm	153	915	16.7%	cbioportal
6	SMARCA4	Ssm	92	915	10.1%	cbioportal
7	PTPRD	Ssm	89	915	9.7%	cbioportal
8	RBM10	Ssm	78	915	8.5%	cbioportal
9	FAT1	Ssm	71	915	7.8%	cbioportal
10	ARID1A	Ssm	69	915	7.5%	cbioportal
11	NF1	Ssm	67	915	7.3%	cbioportal
12	PTPRT	Ssm	67	915	7.3%	cbioportal
14	PIK3CA	Ssm	65	915	7.1%	cbioportal
13	ATM	Ssm	65	915	7.1%	cbioportal
15	EPHA3	Ssm	59	915	6.4%	cbioportal
16	KMT2D	Ssm	58	915	6.3%	cbioportal
17	HGF	Ssm	56	915	6.1%	cbioportal
18	SETD2	Ssm	56	915	6.1%	cbioportal
19	KMT2C	Ssm	53	915	5.8%	cbioportal
20	ATRX	Ssm	52	915	5.7%	cbioportal
23	RB1	Ssm	50	915	5.5%	cbioportal
21	BRAF	Ssm	50	915	5.5%	cbioportal
22	EPHA5	Ssm	50	915	5.5%	cbioportal
42	ZFHX3	Ssm	34	623	5.5%	cbioportal
25	CDKN2A	Ssm	49	915	5.4%	cbioportal
24	APC	Ssm	49	915	5.4%	cbioportal
50	EPHA7	Ssm	31	623	5%	cbioportal
26	ARID2	Ssm	45	915	4.9%	cbioportal
27	NTRK3	Ssm	44	915	4.8%	cbioportal
55	MGA	Ssm	29	623	4.7%	cbioportal

Data updated 22 days agoSource updated 2026-04-07

Non-Small Cell Lung Cancer Brain Metastasis (MSK, Nat Commun 2023) bm_nsclc_mskcc_2023MSK

322 cases with simple somatic mutation data · 322 cases total · 2026-01-05 · mapped to Lung Non-Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	229	322	71.1%	cbioportal
2	KRAS	Ssm	90	322	28%	cbioportal
3	EGFR	Ssm	74	322	23%	cbioportal
4	KEAP1	Ssm	69	322	21.4%	cbioportal
5	STK11	Ssm	60	322	18.6%	cbioportal
6	PTPRT	Ssm	46	322	14.3%	cbioportal
7	ARID1A	Ssm	44	322	13.7%	cbioportal
8	SMARCA4	Ssm	42	322	13%	cbioportal
9	PTPRD	Ssm	38	322	11.8%	cbioportal
11	KMT2D	Ssm	37	322	11.5%	cbioportal
10	ATM	Ssm	37	322	11.5%	cbioportal
12	FAT1	Ssm	35	322	10.9%	cbioportal
13	NF1	Ssm	32	322	9.9%	cbioportal
17	ZFHX3	Ssm	30	304	9.9%	cbioportal
30	PREX2	Ssm	23	236	9.7%	cbioportal
14	CDKN2A	Ssm	31	322	9.6%	cbioportal
16	KMT2C	Ssm	30	322	9.3%	cbioportal
15	EPHA5	Ssm	30	322	9.3%	cbioportal
18	RB1	Ssm	29	322	9%	cbioportal
19	APC	Ssm	28	322	8.7%	cbioportal
21	HGF	Ssm	27	322	8.4%	cbioportal
20	EPHA3	Ssm	27	322	8.4%	cbioportal
22	RBM10	Ssm	27	322	8.4%	cbioportal
23	CREBBP	Ssm	26	322	8.1%	cbioportal
24	PIK3CA	Ssm	26	322	8.1%	cbioportal
25	SETD2	Ssm	25	322	7.8%	cbioportal
29	MGA	Ssm	23	304	7.6%	cbioportal
27	PDGFRA	Ssm	24	322	7.5%	cbioportal
26	ALK	Ssm	24	322	7.5%	cbioportal
28	FLT4	Ssm	23	322	7.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Non-Small Cell Lung Cancer (MSK, 2026) alk_msk_2026MSK

90 cases with simple somatic mutation data · 90 cases total · 2026-06-23 · mapped to Lung Non-Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	26	90	28.9%	cbioportal
2	ALK	Ssm	18	90	20%	cbioportal
5	USP8	Ssm	9	46	19.6%	cbioportal
3	CDKN2A	Ssm	11	90	12.2%	cbioportal
4	KMT2C	Ssm	10	90	11.1%	cbioportal
26	HLA-C	Ssm	5	46	10.9%	cbioportal
58	MARCHF7	Ssm	4	37	10.8%	cbioportal
75	ZNF141	Ssm	4	37	10.8%	cbioportal
62	MTTP	Ssm	4	37	10.8%	cbioportal
6	ZFHX3	Ssm	9	86	10.5%	cbioportal
7	SETD2	Ssm	8	90	8.9%	cbioportal
69	REST	Ssm	4	46	8.7%	cbioportal
13	MST1	Ssm	7	86	8.1%	cbioportal
100	HLA-G	Ssm	3	37	8.1%	cbioportal
125	PPIAL4G	Ssm	3	37	8.1%	cbioportal
119	NPAP1	Ssm	3	37	8.1%	cbioportal
91	DPP6	Ssm	3	37	8.1%	cbioportal
89	CWC22	Ssm	3	37	8.1%	cbioportal
130	SLFN13	Ssm	3	37	8.1%	cbioportal
14	PIK3C2G	Ssm	7	90	7.8%	cbioportal
9	ATM	Ssm	7	90	7.8%	cbioportal
8	ARID1A	Ssm	7	90	7.8%	cbioportal
10	BRCA1	Ssm	7	90	7.8%	cbioportal
11	ERBB2	Ssm	7	90	7.8%	cbioportal
16	TSC2	Ssm	7	90	7.8%	cbioportal
15	PTPRD	Ssm	7	90	7.8%	cbioportal
12	FAT1	Ssm	7	90	7.8%	cbioportal
21	SOS1	Ssm	6	80	7.5%	cbioportal
18	KMT2D	Ssm	6	90	6.7%	cbioportal
17	EP300	Ssm	6	90	6.7%	cbioportal

Data updated 22 days agoSource updated 2026-06-23

Non-Small Cell Lung Cancer (MSK, Cancer Cell 2018) nsclc_mskcc_2018MSK

75 cases with simple somatic mutation data · 75 cases total · 2026-01-12 · mapped to Lung Non-Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	42	75	56%	cbioportal
2	TTN	Ssm	36	75	48%	cbioportal
3	RYR2	Ssm	30	75	40%	cbioportal
4	MUC16	Ssm	25	75	33.3%	cbioportal
5	KRAS	Ssm	23	75	30.7%	cbioportal
6	USH2A	Ssm	22	75	29.3%	cbioportal
7	CSMD3	Ssm	20	75	26.7%	cbioportal
9	OBSCN	Ssm	19	75	25.3%	cbioportal
8	LRP1B	Ssm	19	75	25.3%	cbioportal
11	ZFHX4	Ssm	18	75	24%	cbioportal
10	XIRP2	Ssm	18	75	24%	cbioportal
13	FLG	Ssm	16	75	21.3%	cbioportal
12	FAT3	Ssm	16	75	21.3%	cbioportal
16	MUC17	Ssm	15	75	20%	cbioportal
15	CTNND2	Ssm	15	75	20%	cbioportal
14	COL22A1	Ssm	15	75	20%	cbioportal
23	RELN	Ssm	14	75	18.7%	cbioportal
21	DYNC2H1	Ssm	14	75	18.7%	cbioportal
20	DNAH5	Ssm	14	75	18.7%	cbioportal
19	DNAH11	Ssm	14	75	18.7%	cbioportal
18	CACNA1E	Ssm	14	75	18.7%	cbioportal
17	ANK2	Ssm	14	75	18.7%	cbioportal
22	FLNC	Ssm	14	75	18.7%	cbioportal
28	SYNE1	Ssm	13	75	17.3%	cbioportal
26	PCDH15	Ssm	13	75	17.3%	cbioportal
25	CSMD1	Ssm	13	75	17.3%	cbioportal
24	COL11A1	Ssm	13	75	17.3%	cbioportal
27	SPTA1	Ssm	13	75	17.3%	cbioportal
30	APOB	Ssm	12	75	16%	cbioportal
29	ANKRD30B	Ssm	12	75	16%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Non-Small Cell Lung Cancer (MSK, J Clin Oncol 2018) nsclc_pd1_msk_2018MSK

240 cases with simple somatic mutation data · 240 cases total · 2026-01-12 · mapped to Lung Non-Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	141	240	58.8%	cbioportal
2	KRAS	Ssm	86	240	35.8%	cbioportal
3	KEAP1	Ssm	53	240	22.1%	cbioportal
4	STK11	Ssm	53	240	22.1%	cbioportal
5	PTPRD	Ssm	30	240	12.5%	cbioportal
6	SMARCA4	Ssm	27	240	11.3%	cbioportal
8	RBM10	Ssm	26	240	10.8%	cbioportal
7	EGFR	Ssm	26	240	10.8%	cbioportal
10	KMT2C	Ssm	25	240	10.4%	cbioportal
12	PTPRT	Ssm	25	240	10.4%	cbioportal
11	NF1	Ssm	25	240	10.4%	cbioportal
9	EPHA5	Ssm	25	240	10.4%	cbioportal
13	EPHA3	Ssm	24	240	10%	cbioportal
14	FAT1	Ssm	24	240	10%	cbioportal
15	ARID1A	Ssm	23	240	9.6%	cbioportal
16	KMT2D	Ssm	23	240	9.6%	cbioportal
21	MGA	Ssm	17	184	9.2%	cbioportal
27	EPHA7	Ssm	15	184	8.2%	cbioportal
18	PIK3CG	Ssm	19	240	7.9%	cbioportal
17	ATM	Ssm	19	240	7.9%	cbioportal
19	CDKN2A	Ssm	18	240	7.5%	cbioportal
20	HGF	Ssm	17	240	7.1%	cbioportal
23	TERT	Ssm	17	240	7.1%	cbioportal
22	NOTCH4	Ssm	17	240	7.1%	cbioportal
26	SETD2	Ssm	16	240	6.7%	cbioportal
25	RB1	Ssm	16	240	6.7%	cbioportal
24	ERBB4	Ssm	16	240	6.7%	cbioportal
45	ZFHX3	Ssm	12	184	6.5%	cbioportal
42	PGR	Ssm	12	184	6.5%	cbioportal
28	ALK	Ssm	14	240	5.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Non-Small Cell Lung Cancer (MSK, Science 2015) nsclc_mskcc_2015MSK

16 cases with simple somatic mutation data · 16 cases total · 2026-01-08 · mapped to Lung Non-Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	8	16	50%	cbioportal
2	MUC16	Ssm	7	16	43.8%	cbioportal
3	MUC4	Ssm	7	16	43.8%	cbioportal
4	TTN	Ssm	7	16	43.8%	cbioportal
6	RYR2	Ssm	6	16	37.5%	cbioportal
5	CSMD3	Ssm	6	16	37.5%	cbioportal
11	MUC5B	Ssm	5	16	31.3%	cbioportal
7	DCHS2	Ssm	5	16	31.3%	cbioportal
8	FLG	Ssm	5	16	31.3%	cbioportal
10	LRP1B	Ssm	5	16	31.3%	cbioportal
9	KRAS	Ssm	5	16	31.3%	cbioportal
12	PAPPA2	Ssm	5	16	31.3%	cbioportal
13	PKD1	Ssm	5	16	31.3%	cbioportal
17	COL11A1	Ssm	4	16	25%	cbioportal
28	MUC17	Ssm	4	16	25%	cbioportal
27	MROH2B	Ssm	4	16	25%	cbioportal
26	MAGEC1	Ssm	4	16	25%	cbioportal
15	ANK2	Ssm	4	16	25%	cbioportal
16	CACNA1A	Ssm	4	16	25%	cbioportal
25	HRNR	Ssm	4	16	25%	cbioportal
24	HMCN1	Ssm	4	16	25%	cbioportal
23	FLNC	Ssm	4	16	25%	cbioportal
14	ABCA9	Ssm	4	16	25%	cbioportal
22	DLGAP3	Ssm	4	16	25%	cbioportal
21	DCAF12L1	Ssm	4	16	25%	cbioportal
29	MYO9B	Ssm	4	16	25%	cbioportal
18	CROCC	Ssm	4	16	25%	cbioportal
20	CSMD2	Ssm	4	16	25%	cbioportal
19	CSMD1	Ssm	4	16	25%	cbioportal
30	NALCN	Ssm	4	16	25%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) nsclc_tracerx_2017TRACERx

447 cases with simple somatic mutation data · 447 cases total · 2026-01-12 · mapped to Lung Non-Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	257	447	57.5%	cbioportal
2	TTN	Ssm	209	447	46.8%	cbioportal
3	CSMD3	Ssm	155	447	34.7%	cbioportal
4	RYR2	Ssm	154	447	34.5%	cbioportal
5	LRP1B	Ssm	130	447	29.1%	cbioportal
6	ZFHX4	Ssm	109	447	24.4%	cbioportal
7	KRAS	Ssm	103	447	23%	cbioportal
8	USH2A	Ssm	96	447	21.5%	cbioportal
9	MUC16	Ssm	91	447	20.4%	cbioportal
10	RYR3	Ssm	89	447	19.9%	cbioportal
11	UNC80	Ssm	88	447	19.7%	cbioportal
12	CSMD1	Ssm	85	447	19%	cbioportal
13	XIRP2	Ssm	81	447	18.1%	cbioportal
14	LRP2	Ssm	79	447	17.7%	cbioportal
15	SI	Ssm	78	447	17.4%	cbioportal
16	CACNA1E	Ssm	77	447	17.2%	cbioportal
17	OBSCN	Ssm	75	447	16.8%	cbioportal
18	COL22A1	Ssm	74	447	16.6%	cbioportal
19	SPTA1	Ssm	74	447	16.6%	cbioportal
20	SYNE1	Ssm	74	447	16.6%	cbioportal
22	EYS	Ssm	73	447	16.3%	cbioportal
21	CSMD2	Ssm	73	447	16.3%	cbioportal
23	RELN	Ssm	70	447	15.7%	cbioportal
24	CNTNAP5	Ssm	69	447	15.4%	cbioportal
25	CNTNAP2	Ssm	68	447	15.2%	cbioportal
26	NEB	Ssm	68	447	15.2%	cbioportal
27	DNAH9	Ssm	67	447	15%	cbioportal
28	FAM135B	Ssm	66	447	14.8%	cbioportal
29	PAPPA2	Ssm	65	447	14.5%	cbioportal
30	FSIP2	Ssm	64	447	14.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Non-Small Cell Lung Cancer (University of Turin, Lung Cancer 2017) nsclc_unito_2016University of Turin

41 cases with simple somatic mutation data · 41 cases total · 2026-01-12 · mapped to Lung Non-Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved29 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	22	41	53.7%	cbioportal
2	EGFR	Ssm	12	41	29.3%	cbioportal
3	KRAS	Ssm	10	41	24.4%	cbioportal
4	ATM	Ssm	6	41	14.6%	cbioportal
5	STK11	Ssm	5	41	12.2%	cbioportal
6	PIK3CA	Ssm	4	41	9.8%	cbioportal
7	BRAF	Ssm	3	41	7.3%	cbioportal
8	FGFR3	Ssm	3	41	7.3%	cbioportal
9	KDR	Ssm	3	41	7.3%	cbioportal
10	KIT	Ssm	3	41	7.3%	cbioportal
11	MET	Ssm	3	41	7.3%	cbioportal
12	SMAD4	Ssm	3	41	7.3%	cbioportal
15	CDKN2A	Ssm	2	41	4.9%	cbioportal
13	APC	Ssm	2	41	4.9%	cbioportal
14	CDH1	Ssm	2	41	4.9%	cbioportal
16	PTPN11	Ssm	2	41	4.9%	cbioportal
17	RB1	Ssm	2	41	4.9%	cbioportal
18	RET	Ssm	2	41	4.9%	cbioportal
19	VHL	Ssm	2	41	4.9%	cbioportal
27	IDH1	Ssm	1	41	2.4%	cbioportal
29	SMO	Ssm	1	41	2.4%	cbioportal
28	NOTCH1	Ssm	1	41	2.4%	cbioportal
20	ABL1	Ssm	1	41	2.4%	cbioportal
21	AKT1	Ssm	1	41	2.4%	cbioportal
22	ERBB2	Ssm	1	41	2.4%	cbioportal
23	ERBB4	Ssm	1	41	2.4%	cbioportal
24	FGFR2	Ssm	1	41	2.4%	cbioportal
25	FLT3	Ssm	1	41	2.4%	cbioportal
26	HNF1A	Ssm	1	41	2.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pan-Lung Cancer (TCGA, Nat Genet 2016) nsclc_tcga_broad_2016TCGA

1,144 cases with simple somatic mutation data · 1,144 cases total · 2026-01-12 · mapped to Lung Non-Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	775	1,144	67.7%	cbioportal
2	TTN	Ssm	682	1,144	59.6%	cbioportal
3	CSMD3	Ssm	477	1,144	41.7%	cbioportal
4	MUC16	Ssm	463	1,144	40.5%	cbioportal
5	RYR2	Ssm	448	1,144	39.2%	cbioportal
6	LRP1B	Ssm	402	1,144	35.1%	cbioportal
7	USH2A	Ssm	390	1,144	34.1%	cbioportal
8	ZFHX4	Ssm	356	1,144	31.1%	cbioportal
9	SPTA1	Ssm	284	1,144	24.8%	cbioportal
10	XIRP2	Ssm	268	1,144	23.4%	cbioportal
11	FLG	Ssm	253	1,144	22.1%	cbioportal
12	SYNE1	Ssm	253	1,144	22.1%	cbioportal
13	NAV3	Ssm	234	1,144	20.5%	cbioportal
14	PCDH15	Ssm	230	1,144	20.1%	cbioportal
15	CSMD1	Ssm	225	1,144	19.7%	cbioportal
16	FAM135B	Ssm	223	1,144	19.5%	cbioportal
17	FAT3	Ssm	222	1,144	19.4%	cbioportal
18	KRAS	Ssm	222	1,144	19.4%	cbioportal
20	PCLO	Ssm	219	1,144	19.1%	cbioportal
19	MUC17	Ssm	219	1,144	19.1%	cbioportal
21	RYR3	Ssm	217	1,144	19%	cbioportal
22	COL11A1	Ssm	214	1,144	18.7%	cbioportal
23	PAPPA2	Ssm	212	1,144	18.5%	cbioportal
24	APOB	Ssm	210	1,144	18.4%	cbioportal
25	SI	Ssm	203	1,144	17.7%	cbioportal
26	CDH10	Ssm	202	1,144	17.7%	cbioportal
27	DNAH9	Ssm	197	1,144	17.2%	cbioportal
28	ADAMTS12	Ssm	196	1,144	17.1%	cbioportal
29	ZNF536	Ssm	195	1,144	17%	cbioportal
30	TNR	Ssm	192	1,144	16.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Small Cell Lung Cancer (CLCGP, Nat Genet 2012) sclc_clcgpCLCGP

29 cases with simple somatic mutation data · 29 cases total · 2026-01-13 · mapped to Lung Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	26	29	89.7%	cbioportal
2	RB1	Ssm	19	29	65.5%	cbioportal
4	USH2A	Ssm	13	29	44.8%	cbioportal
3	LRP1B	Ssm	13	29	44.8%	cbioportal
5	TTN	Ssm	11	29	37.9%	cbioportal
7	PKHD1	Ssm	10	29	34.5%	cbioportal
6	CSMD3	Ssm	10	29	34.5%	cbioportal
9	MUC17	Ssm	9	29	31%	cbioportal
8	COL11A1	Ssm	9	29	31%	cbioportal
10	PRDM9	Ssm	9	29	31%	cbioportal
14	ZNF521	Ssm	8	29	27.6%	cbioportal
13	SYNE1	Ssm	8	29	27.6%	cbioportal
12	SPHKAP	Ssm	8	29	27.6%	cbioportal
11	DMD	Ssm	8	29	27.6%	cbioportal
15	ZNF536	Ssm	8	29	27.6%	cbioportal
16	CSMD2	Ssm	7	29	24.1%	cbioportal
21	TNN	Ssm	7	29	24.1%	cbioportal
22	ZNF804A	Ssm	7	29	24.1%	cbioportal
20	TMEM132D	Ssm	7	29	24.1%	cbioportal
19	TKTL2	Ssm	7	29	24.1%	cbioportal
18	SI	Ssm	7	29	24.1%	cbioportal
17	FLG	Ssm	7	29	24.1%	cbioportal
30	HCN1	Ssm	6	29	20.7%	cbioportal
28	ERICH3	Ssm	6	29	20.7%	cbioportal
27	ERBB4	Ssm	6	29	20.7%	cbioportal
26	DNAH9	Ssm	6	29	20.7%	cbioportal
25	COL22A1	Ssm	6	29	20.7%	cbioportal
24	CDH10	Ssm	6	29	20.7%	cbioportal
23	ANKRD30A	Ssm	6	29	20.7%	cbioportal
29	FAT4	Ssm	6	29	20.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Small Cell Lung Cancer (Johns Hopkins, Nat Genet 2012) sclc_jhuJohns Hopkins

80 cases with simple somatic mutation data · 80 cases total · 2026-01-13 · mapped to Lung Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	36	80	45%	cbioportal
2	RB1	Ssm	19	80	23.8%	cbioportal
3	CSMD3	Ssm	17	80	21.3%	cbioportal
4	TTN	Ssm	16	80	20%	cbioportal
5	LRP1B	Ssm	15	80	18.8%	cbioportal
6	MUC17	Ssm	12	80	15%	cbioportal
8	USH2A	Ssm	11	80	13.8%	cbioportal
7	HCN1	Ssm	11	80	13.8%	cbioportal
9	DNAH7	Ssm	10	80	12.5%	cbioportal
12	SYNE1	Ssm	9	80	11.3%	cbioportal
11	COL22A1	Ssm	9	80	11.3%	cbioportal
10	COL11A1	Ssm	9	80	11.3%	cbioportal
14	GRIN2B	Ssm	8	80	10%	cbioportal
13	BRINP3	Ssm	8	80	10%	cbioportal
24	PKHD1	Ssm	7	80	8.8%	cbioportal
15	ANK2	Ssm	7	80	8.8%	cbioportal
16	DNAH5	Ssm	7	80	8.8%	cbioportal
17	ERICH3	Ssm	7	80	8.8%	cbioportal
18	FAM135B	Ssm	7	80	8.8%	cbioportal
19	FSIP2	Ssm	7	80	8.8%	cbioportal
20	KIF21A	Ssm	7	80	8.8%	cbioportal
21	MORC1	Ssm	7	80	8.8%	cbioportal
22	MYH2	Ssm	7	80	8.8%	cbioportal
23	NAV3	Ssm	7	80	8.8%	cbioportal
25	RYR2	Ssm	7	80	8.8%	cbioportal
30	DIP2C	Ssm	6	80	7.5%	cbioportal
29	DCC	Ssm	6	80	7.5%	cbioportal
26	ADGRG4	Ssm	6	80	7.5%	cbioportal
27	CNTNAP2	Ssm	6	80	7.5%	cbioportal
28	COL4A2	Ssm	6	80	7.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Small-Cell Lung Cancer (Multi-Institute, Cancer Cell 2017) sclc_cancercell_gardner_2017Multi-Institute

20 cases with simple somatic mutation data · 20 cases total · 2026-01-13 · mapped to Lung Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	POLE	Ssm	20	20	100%	cbioportal
3	GRIN2C	Ssm	19	20	95%	cbioportal
2	CUBN	Ssm	19	20	95%	cbioportal
10	OR10Q1	Ssm	18	20	90%	cbioportal
5	DBN1	Ssm	18	20	90%	cbioportal
4	CATSPERT	Ssm	18	20	90%	cbioportal
7	FSIP2	Ssm	18	20	90%	cbioportal
8	GART	Ssm	18	20	90%	cbioportal
9	MUC16	Ssm	18	20	90%	cbioportal
6	DGKG	Ssm	18	20	90%	cbioportal
13	PIKFYVE	Ssm	17	20	85%	cbioportal
12	OBSCN	Ssm	17	20	85%	cbioportal
11	IGLV1-47	Ssm	17	20	85%	cbioportal
19	AHNAK2	Ssm	16	20	80%	cbioportal
29	BCL2L2	Ssm	16	20	80%	cbioportal
28	B3GALT5-AS1	Ssm	16	20	80%	cbioportal
27	ATP11A	Ssm	16	20	80%	cbioportal
26	ATG2B	Ssm	16	20	80%	cbioportal
25	ARMC9	Ssm	16	20	80%	cbioportal
24	ARHGAP22	Ssm	16	20	80%	cbioportal
23	AP3B1	Ssm	16	20	80%	cbioportal
22	ANTXR2	Ssm	16	20	80%	cbioportal
21	ANKS6	Ssm	16	20	80%	cbioportal
20	AKAP9	Ssm	16	20	80%	cbioportal
30	C4ORF36	Ssm	16	20	80%	cbioportal
18	AHNAK	Ssm	16	20	80%	cbioportal
17	ADGRG6	Ssm	16	20	80%	cbioportal
16	ADAM22	Ssm	16	20	80%	cbioportal
15	ABCB11	Ssm	16	20	80%	cbioportal
14	ABCA6	Ssm	16	20	80%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Small Cell Lung Cancer (U Cologne, Nature 2015) sclc_ucologne_2015U Cologne

120 cases with simple somatic mutation data · 120 cases total · 2026-01-13 · mapped to Lung Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	103	120	85.8%	cbioportal
2	RB1	Ssm	87	120	72.5%	cbioportal
3	TTN	Ssm	77	120	64.2%	cbioportal
4	RYR2	Ssm	54	120	45%	cbioportal
5	LRP1B	Ssm	51	120	42.5%	cbioportal
6	MUC16	Ssm	49	120	40.8%	cbioportal
7	ZFHX4	Ssm	46	120	38.3%	cbioportal
8	USH2A	Ssm	44	120	36.7%	cbioportal
9	CSMD3	Ssm	42	120	35%	cbioportal
10	NAV3	Ssm	35	120	29.2%	cbioportal
11	PCDH15	Ssm	32	120	26.7%	cbioportal
12	COL11A1	Ssm	31	120	25.8%	cbioportal
13	CSMD1	Ssm	28	120	23.3%	cbioportal
16	SYNE1	Ssm	27	120	22.5%	cbioportal
14	EYS	Ssm	27	120	22.5%	cbioportal
15	MUC17	Ssm	27	120	22.5%	cbioportal
18	FAM135B	Ssm	26	120	21.7%	cbioportal
17	ANKRD30B	Ssm	26	120	21.7%	cbioportal
19	FSIP2	Ssm	25	120	20.8%	cbioportal
20	TMEM132D	Ssm	25	120	20.8%	cbioportal
21	ERICH3	Ssm	24	120	20%	cbioportal
22	PKHD1	Ssm	24	120	20%	cbioportal
23	SI	Ssm	24	120	20%	cbioportal
25	RYR1	Ssm	23	120	19.2%	cbioportal
24	PKHD1L1	Ssm	23	120	19.2%	cbioportal
27	TENM1	Ssm	23	120	19.2%	cbioportal
26	SPTA1	Ssm	23	120	19.2%	cbioportal
28	XIRP2	Ssm	23	120	19.2%	cbioportal
29	ADGB	Ssm	22	120	18.3%	cbioportal
30	FAT3	Ssm	22	120	18.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13