Kidney Carcinoma — Genomics

Kidney Carcinoma — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

24 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Chromophobe Renal Cell Carcinoma (TCGA GDC, 2025) chrcc_tcga_gdcTCGA GDC

66 cases with simple somatic mutation data · 66 cases total · 2026-01-13 · mapped to Chromophobe Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Clear Cell Renal Cell Carcinoma (DFCI, Science 2019) ccrcc_dfci_2019DFCI

35 cases with simple somatic mutation data · 35 cases total · 2026-01-05 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	25	35	71.4%	cbioportal
2	PBRM1	Ssm	19	35	54.3%	cbioportal
3	SETD2	Ssm	15	35	42.9%	cbioportal
5	MACF1	Ssm	7	35	20%	cbioportal
4	KDM5C	Ssm	7	35	20%	cbioportal
7	TTN	Ssm	6	35	17.1%	cbioportal
6	CACNA1I	Ssm	6	35	17.1%	cbioportal
8	BAP1	Ssm	5	35	14.3%	cbioportal
13	HDAC9	Ssm	4	35	11.4%	cbioportal
17	VPS13B	Ssm	4	35	11.4%	cbioportal
16	USP32	Ssm	4	35	11.4%	cbioportal
15	MTOR	Ssm	4	35	11.4%	cbioportal
14	ITCH	Ssm	4	35	11.4%	cbioportal
12	DYNC1I1	Ssm	4	35	11.4%	cbioportal
11	DACH2	Ssm	4	35	11.4%	cbioportal
10	ATXN7L1	Ssm	4	35	11.4%	cbioportal
9	AK9	Ssm	4	35	11.4%	cbioportal
26	FIRRM	Ssm	3	35	8.6%	cbioportal
25	EPB41	Ssm	3	35	8.6%	cbioportal
24	DNAH14	Ssm	3	35	8.6%	cbioportal
23	CTNNA2	Ssm	3	35	8.6%	cbioportal
22	CLCA4	Ssm	3	35	8.6%	cbioportal
21	CHD9	Ssm	3	35	8.6%	cbioportal
20	CD2AP	Ssm	3	35	8.6%	cbioportal
19	CABIN1	Ssm	3	35	8.6%	cbioportal
18	ADAMTS16	Ssm	3	35	8.6%	cbioportal
30	HUWE1	Ssm	3	35	8.6%	cbioportal
29	HMCN1	Ssm	3	35	8.6%	cbioportal
28	HIF1A	Ssm	3	35	8.6%	cbioportal
27	GUCY2C	Ssm	3	35	8.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Kidney Chromophobe TCGA-KICHTCGA

86 cases with simple somatic mutation data · 113 cases total · Data Release 46.0 · mapped to Chromophobe Renal Cell Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	GPRIN2	Ssm	61	86	70.9%	gdc
2	SCNN1D	Ssm	59	86	68.6%	gdc
3	SYT15	Ssm	59	86	68.6%	gdc
4	NBPF1	Ssm	59	86	68.6%	gdc
8	FAM131C	Ssm	59	86	68.6%	gdc
9	CROCC	Ssm	59	86	68.6%	gdc
7	GABRD	Ssm	59	86	68.6%	gdc
6	ACAP3	Ssm	59	86	68.6%	gdc
10	ANXA8L1	Ssm	59	86	68.6%	gdc
5	TP53	Ssm	59	86	68.6%	gdc
17	KCNAB2	Ssm	58	86	67.4%	gdc
19	TMEM240	Ssm	58	86	67.4%	gdc
20	DUSP22	Ssm	58	86	67.4%	gdc
21	MIB2	Ssm	58	86	67.4%	gdc
22	TMEM52	Ssm	58	86	67.4%	gdc
23	ATAD3A	Ssm	58	86	67.4%	gdc
24	NADK	Ssm	58	86	67.4%	gdc
25	TAS1R1	Ssm	58	86	67.4%	gdc
26	GNB1	Ssm	58	86	67.4%	gdc
27	DFFA	Ssm	58	86	67.4%	gdc
28	MMP23B	Ssm	58	86	67.4%	gdc
29	ATAD3C	Ssm	58	86	67.4%	gdc
30	NECAP2	Ssm	58	86	67.4%	gdc
13	CDK11A	Ssm	58	86	67.4%	gdc
14	TTC34	Ssm	58	86	67.4%	gdc
15	SSU72	Ssm	58	86	67.4%	gdc
16	PUSL1	Ssm	58	86	67.4%	gdc
18	MRPL20	Ssm	58	86	67.4%	gdc
11	INTS11	Ssm	58	86	67.4%	gdc
12	UBE2J2	Ssm	58	86	67.4%	gdc

Data updated 23 days agoSource updated Data Release 46.0

Kidney Chromophobe (TCGA, Cancer Cell 2014) kich_tcga_pubTCGA

65 cases with simple somatic mutation data · 66 cases total · 2026-01-07 · mapped to Chromophobe Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	20	65	30.8%	cbioportal
2	PTEN	Ssm	6	65	9.2%	cbioportal
5	TTN	Ssm	3	65	4.6%	cbioportal
4	ICE1	Ssm	3	65	4.6%	cbioportal
3	CRACD	Ssm	3	65	4.6%	cbioportal
22	DDX50	Ssm	2	65	3.1%	cbioportal
30	FLT4	Ssm	2	65	3.1%	cbioportal
29	ESPL1	Ssm	2	65	3.1%	cbioportal
28	ENTREP3	Ssm	2	65	3.1%	cbioportal
27	ELAPOR1	Ssm	2	65	3.1%	cbioportal
26	DYNC2H1	Ssm	2	65	3.1%	cbioportal
25	DSPP	Ssm	2	65	3.1%	cbioportal
24	DSCAM	Ssm	2	65	3.1%	cbioportal
23	DIDO1	Ssm	2	65	3.1%	cbioportal
21	CSMD1	Ssm	2	65	3.1%	cbioportal
20	CSF2RB	Ssm	2	65	3.1%	cbioportal
19	CLCN2	Ssm	2	65	3.1%	cbioportal
18	CDKN1A	Ssm	2	65	3.1%	cbioportal
17	CDC27	Ssm	2	65	3.1%	cbioportal
16	CASP5	Ssm	2	65	3.1%	cbioportal
15	CACNA1B	Ssm	2	65	3.1%	cbioportal
14	CACNA1A	Ssm	2	65	3.1%	cbioportal
13	C3ORF20	Ssm	2	65	3.1%	cbioportal
12	BLTP1	Ssm	2	65	3.1%	cbioportal
11	BAIAP2L2	Ssm	2	65	3.1%	cbioportal
10	ATM	Ssm	2	65	3.1%	cbioportal
9	ARHGEF2	Ssm	2	65	3.1%	cbioportal
8	AICDA	Ssm	2	65	3.1%	cbioportal
7	AFF3	Ssm	2	65	3.1%	cbioportal
6	ADAMTS7	Ssm	2	65	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Kidney Chromophobe (TCGA, Firehose Legacy) kich_tcgaTCGA

66 cases with simple somatic mutation data · 113 cases total · 2026-01-07 · mapped to Chromophobe Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4	Ssm	46	66	69.7%	cbioportal
2	FRG1BP	Ssm	33	66	50%	cbioportal
4	TP53	Ssm	22	66	33.3%	cbioportal
3	MUC6	Ssm	22	66	33.3%	cbioportal
6	MUC2	Ssm	15	66	22.7%	cbioportal
5	MUC16	Ssm	15	66	22.7%	cbioportal
7	FRG1	Ssm	14	66	21.2%	cbioportal
8	MUC5B	Ssm	12	66	18.2%	cbioportal
9	NBPF10	Ssm	12	66	18.2%	cbioportal
10	CDC27	Ssm	11	66	16.7%	cbioportal
12	KMT2C	Ssm	10	66	15.2%	cbioportal
11	AHNAK2	Ssm	10	66	15.2%	cbioportal
14	PABPC1	Ssm	8	66	12.1%	cbioportal
15	PABPC3	Ssm	8	66	12.1%	cbioportal
13	DSPP	Ssm	8	66	12.1%	cbioportal
16	HLA-C	Ssm	7	66	10.6%	cbioportal
24	PRSS3	Ssm	6	66	9.1%	cbioportal
17	DDX11	Ssm	6	66	9.1%	cbioportal
18	GOLGA6L6	Ssm	6	66	9.1%	cbioportal
19	HLA-A	Ssm	6	66	9.1%	cbioportal
20	MUC17	Ssm	6	66	9.1%	cbioportal
21	MUC21	Ssm	6	66	9.1%	cbioportal
22	PCDHA8	Ssm	6	66	9.1%	cbioportal
23	PRB2	Ssm	6	66	9.1%	cbioportal
25	PTEN	Ssm	6	66	9.1%	cbioportal
26	RBMXL1	Ssm	6	66	9.1%	cbioportal
27	SLC35G5	Ssm	6	66	9.1%	cbioportal
28	TAS2R43	Ssm	6	66	9.1%	cbioportal
29	ZNF469	Ssm	6	66	9.1%	cbioportal
30	ADAMTS7	Ssm	5	66	7.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Kidney Chromophobe (TCGA, PanCancer Atlas) kich_tcga_pan_can_atlas_2018TCGA

65 cases with simple somatic mutation data · 65 cases total · 2026-06-23 · mapped to Chromophobe Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	21	65	32.3%	cbioportal
2	PTEN	Ssm	6	65	9.2%	cbioportal
3	ZAN	Ssm	5	65	7.7%	cbioportal
4	HERC2	Ssm	4	65	6.2%	cbioportal
5	TTN	Ssm	4	65	6.2%	cbioportal
6	ATG2A	Ssm	3	65	4.6%	cbioportal
7	BIRC6	Ssm	3	65	4.6%	cbioportal
8	CFAP47	Ssm	3	65	4.6%	cbioportal
9	CSF2RB	Ssm	3	65	4.6%	cbioportal
10	DNAH1	Ssm	3	65	4.6%	cbioportal
12	FLT4	Ssm	3	65	4.6%	cbioportal
11	FAT4	Ssm	3	65	4.6%	cbioportal
13	ICE1	Ssm	3	65	4.6%	cbioportal
14	KALRN	Ssm	3	65	4.6%	cbioportal
15	MUC16	Ssm	3	65	4.6%	cbioportal
16	PCLO	Ssm	3	65	4.6%	cbioportal
17	ZFHX4	Ssm	3	65	4.6%	cbioportal
23	AGBL1	Ssm	2	65	3.1%	cbioportal
29	ARFGAP3	Ssm	2	65	3.1%	cbioportal
28	ANKRD17	Ssm	2	65	3.1%	cbioportal
27	ANKHD1	Ssm	2	65	3.1%	cbioportal
26	AMPD2	Ssm	2	65	3.1%	cbioportal
25	AICDA	Ssm	2	65	3.1%	cbioportal
18	ABCE1	Ssm	2	65	3.1%	cbioportal
24	AGRN	Ssm	2	65	3.1%	cbioportal
30	ARHGEF18	Ssm	2	65	3.1%	cbioportal
19	ACAP3	Ssm	2	65	3.1%	cbioportal
20	ADAMTSL1	Ssm	2	65	3.1%	cbioportal
21	ADGRB1	Ssm	2	65	3.1%	cbioportal
22	AFF3	Ssm	2	65	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-06-23

Kidney Renal Clear Cell Carcinoma TCGA-KIRCTCGA

536 cases with simple somatic mutation data · 537 cases total · Data Release 46.0 · mapped to Clear Cell Renal Cell Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	463	536	86.4%	gdc
2	PBRM1	Ssm	456	536	85.1%	gdc
3	BAP1	Ssm	451	536	84.1%	gdc
6	GLB1	Ssm	450	536	84%	gdc
5	COL7A1	Ssm	450	536	84%	gdc
4	PLXNB1	Ssm	450	536	84%	gdc
7	TREX1	Ssm	449	536	83.8%	gdc
27	TMEM89	Ssm	449	536	83.8%	gdc
26	IP6K2	Ssm	449	536	83.8%	gdc
25	TMA7	Ssm	449	536	83.8%	gdc
24	ATRIP	Ssm	449	536	83.8%	gdc
23	VIPR1	Ssm	449	536	83.8%	gdc
22	HHATL	Ssm	449	536	83.8%	gdc
21	NCKIPSD	Ssm	449	536	83.8%	gdc
20	SCN5A	Ssm	449	536	83.8%	gdc
19	FBXW12	Ssm	449	536	83.8%	gdc
18	PFKFB4	Ssm	449	536	83.8%	gdc
17	CCDC51	Ssm	449	536	83.8%	gdc
16	SHISA5	Ssm	449	536	83.8%	gdc
15	UCN2	Ssm	449	536	83.8%	gdc
14	SETD2	Ssm	449	536	83.8%	gdc
13	SLC26A6	Ssm	449	536	83.8%	gdc
12	PTH1R	Ssm	449	536	83.8%	gdc
11	UQCRC1	Ssm	449	536	83.8%	gdc
10	PRKAR2A	Ssm	449	536	83.8%	gdc
9	CELSR3	Ssm	449	536	83.8%	gdc
8	CDC25A	Ssm	449	536	83.8%	gdc
30	DCAF1	Ssm	448	536	83.6%	gdc
28	SLC25A20	Ssm	448	536	83.6%	gdc
29	LAMB2	Ssm	448	536	83.6%	gdc

Data updated 23 days agoSource updated Data Release 46.0

Kidney Renal Clear Cell Carcinoma (BGI, Nat Genet 2012) kirc_bgiBGI

98 cases with simple somatic mutation data · 98 cases total · 2026-01-07 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	25	98	25.5%	cbioportal
2	KDM5C	Ssm	9	98	9.2%	cbioportal
4	LRP1B	Ssm	7	98	7.1%	cbioportal
5	SYNE2	Ssm	7	98	7.1%	cbioportal
3	BAP1	Ssm	7	98	7.1%	cbioportal
6	TP53	Ssm	6	98	6.1%	cbioportal
10	RYR1	Ssm	5	98	5.1%	cbioportal
8	AKAP13	Ssm	5	98	5.1%	cbioportal
7	AHNAK	Ssm	5	98	5.1%	cbioportal
11	SPTBN4	Ssm	5	98	5.1%	cbioportal
9	CSMD3	Ssm	5	98	5.1%	cbioportal
14	NAV3	Ssm	4	98	4.1%	cbioportal
13	FAM111B	Ssm	4	98	4.1%	cbioportal
12	CARD11	Ssm	4	98	4.1%	cbioportal
16	ZNF804A	Ssm	4	98	4.1%	cbioportal
15	SETD2	Ssm	4	98	4.1%	cbioportal
23	PZP	Ssm	3	98	3.1%	cbioportal
25	TSC1	Ssm	3	98	3.1%	cbioportal
19	FMN2	Ssm	3	98	3.1%	cbioportal
18	CUL7	Ssm	3	98	3.1%	cbioportal
17	ATRNL1	Ssm	3	98	3.1%	cbioportal
20	KMT2C	Ssm	3	98	3.1%	cbioportal
21	LRRK2	Ssm	3	98	3.1%	cbioportal
22	MTOR	Ssm	3	98	3.1%	cbioportal
24	SHANK1	Ssm	3	98	3.1%	cbioportal
26	ADCY9	Ssm	2	98	2%	cbioportal
29	APC	Ssm	2	98	2%	cbioportal
30	BTRC	Ssm	2	98	2%	cbioportal
28	AGXT	Ssm	2	98	2%	cbioportal
27	AFDN	Ssm	2	98	2%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Kidney Renal Clear Cell Carcinoma (IRC, Nat Genet 2014) ccrcc_irc_2014IRC

78 cases with simple somatic mutation data · 79 cases total · 2026-01-05 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	62	78	79.5%	cbioportal
2	PBRM1	Ssm	29	78	37.2%	cbioportal
3	SETD2	Ssm	21	78	26.9%	cbioportal
4	BAP1	Ssm	19	78	24.4%	cbioportal
5	DOP1A	Ssm	17	78	21.8%	cbioportal
6	UGT2A1	Ssm	15	78	19.2%	cbioportal
7	DAPK1	Ssm	13	78	16.7%	cbioportal
9	CENPF	Ssm	12	78	15.4%	cbioportal
8	ANO5	Ssm	12	78	15.4%	cbioportal
10	MYH8	Ssm	12	78	15.4%	cbioportal
17	PPP6R1	Ssm	11	78	14.1%	cbioportal
16	OR2A14	Ssm	11	78	14.1%	cbioportal
15	MUC16	Ssm	11	78	14.1%	cbioportal
14	ITGB3	Ssm	11	78	14.1%	cbioportal
13	GLTPD2	Ssm	11	78	14.1%	cbioportal
12	EDC4	Ssm	11	78	14.1%	cbioportal
11	DUSP19	Ssm	11	78	14.1%	cbioportal
18	UNC80	Ssm	11	78	14.1%	cbioportal
25	CYP4F3	Ssm	10	78	12.8%	cbioportal
19	ATP11B	Ssm	10	78	12.8%	cbioportal
20	ATXN1	Ssm	10	78	12.8%	cbioportal
21	BCAS2	Ssm	10	78	12.8%	cbioportal
22	C11ORF68	Ssm	10	78	12.8%	cbioportal
23	CCR6	Ssm	10	78	12.8%	cbioportal
24	CLCN2	Ssm	10	78	12.8%	cbioportal
26	DDX52	Ssm	10	78	12.8%	cbioportal
27	EIF4G2	Ssm	10	78	12.8%	cbioportal
28	EXT1	Ssm	10	78	12.8%	cbioportal
29	FCAMR	Ssm	10	78	12.8%	cbioportal
30	GARRE1	Ssm	10	78	12.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Kidney Renal Clear Cell Carcinoma (TCGA, Firehose Legacy) kirc_tcgaTCGA

451 cases with simple somatic mutation data · 538 cases total · 2026-01-07 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	225	451	49.9%	cbioportal
2	PBRM1	Ssm	133	451	29.5%	cbioportal
3	MUC4	Ssm	77	451	17.1%	cbioportal
4	TTN	Ssm	71	451	15.7%	cbioportal
5	MUC16	Ssm	58	451	12.9%	cbioportal
6	SETD2	Ssm	51	451	11.3%	cbioportal
7	BAP1	Ssm	40	451	8.9%	cbioportal
8	MTOR	Ssm	32	451	7.1%	cbioportal
9	FBN2	Ssm	30	451	6.7%	cbioportal
10	XIRP2	Ssm	28	451	6.2%	cbioportal
11	DNAH3	Ssm	27	451	6%	cbioportal
12	KDM5C	Ssm	27	451	6%	cbioportal
13	HMCN1	Ssm	26	451	5.8%	cbioportal
14	ARAP3	Ssm	25	451	5.5%	cbioportal
15	ARID1A	Ssm	25	451	5.5%	cbioportal
16	TSHZ3	Ssm	25	451	5.5%	cbioportal
17	SSH2	Ssm	24	451	5.3%	cbioportal
21	VWF	Ssm	23	451	5.1%	cbioportal
18	AKAP9	Ssm	23	451	5.1%	cbioportal
19	NAV3	Ssm	23	451	5.1%	cbioportal
20	SPEN	Ssm	23	451	5.1%	cbioportal
22	ABCA1	Ssm	22	451	4.9%	cbioportal
23	CD4	Ssm	22	451	4.9%	cbioportal
24	GRIN2B	Ssm	22	451	4.9%	cbioportal
25	MAP1B	Ssm	22	451	4.9%	cbioportal
26	PDZD2	Ssm	22	451	4.9%	cbioportal
27	ABCA6	Ssm	21	451	4.7%	cbioportal
28	DCHS1	Ssm	21	451	4.7%	cbioportal
29	DDB1	Ssm	21	451	4.7%	cbioportal
30	DNMT1	Ssm	21	451	4.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Kidney Renal Clear Cell Carcinoma (TCGA, Nature 2013) kirc_tcga_pubTCGA

426 cases with simple somatic mutation data · 446 cases total · 2026-02-19 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	218	426	51.2%	cbioportal
2	PBRM1	Ssm	145	426	34%	cbioportal
3	MUC4	Ssm	90	426	21.1%	cbioportal
4	TTN	Ssm	63	426	14.8%	cbioportal
5	SETD2	Ssm	55	426	12.9%	cbioportal
6	BAP1	Ssm	42	426	9.9%	cbioportal
7	MUC16	Ssm	34	426	8%	cbioportal
8	KDM5C	Ssm	29	426	6.8%	cbioportal
9	MTOR	Ssm	23	426	5.4%	cbioportal
10	PABPC1	Ssm	19	426	4.5%	cbioportal
11	HMCN1	Ssm	18	426	4.2%	cbioportal
12	AHNAK2	Ssm	17	426	4%	cbioportal
15	USH2A	Ssm	17	426	4%	cbioportal
14	PTEN	Ssm	17	426	4%	cbioportal
13	KMT2C	Ssm	17	426	4%	cbioportal
17	MAGEC1	Ssm	16	426	3.8%	cbioportal
16	MACF1	Ssm	16	426	3.8%	cbioportal
19	DNAH9	Ssm	15	426	3.5%	cbioportal
20	LRP1B	Ssm	15	426	3.5%	cbioportal
21	PCLO	Ssm	15	426	3.5%	cbioportal
22	SYNE1	Ssm	15	426	3.5%	cbioportal
18	ADGRV1	Ssm	15	426	3.5%	cbioportal
24	ATM	Ssm	14	426	3.3%	cbioportal
25	DST	Ssm	14	426	3.3%	cbioportal
26	KMT2D	Ssm	14	426	3.3%	cbioportal
23	ARID1A	Ssm	14	426	3.3%	cbioportal
30	MUC2	Ssm	13	426	3.1%	cbioportal
29	MUC17	Ssm	13	426	3.1%	cbioportal
28	FMN2	Ssm	13	426	3.1%	cbioportal
27	FBN2	Ssm	13	426	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-02-19

Kidney Renal Clear Cell Carcinoma (TCGA, PanCancer Atlas) kirc_tcga_pan_can_atlas_2018TCGA

402 cases with simple somatic mutation data · 512 cases total · 2026-06-05 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	166	402	41.3%	cbioportal
2	PBRM1	Ssm	145	402	36.1%	cbioportal
3	TTN	Ssm	69	402	17.2%	cbioportal
4	SETD2	Ssm	49	402	12.2%	cbioportal
5	BAP1	Ssm	38	402	9.5%	cbioportal
6	MTOR	Ssm	31	402	7.7%	cbioportal
7	MUC16	Ssm	30	402	7.5%	cbioportal
8	KDM5C	Ssm	20	402	5%	cbioportal
9	DNAH9	Ssm	18	402	4.5%	cbioportal
10	CSMD3	Ssm	17	402	4.2%	cbioportal
11	HMCN1	Ssm	17	402	4.2%	cbioportal
12	FBN2	Ssm	16	402	4%	cbioportal
17	XIRP2	Ssm	15	402	3.7%	cbioportal
13	KMT2C	Ssm	15	402	3.7%	cbioportal
15	MACF1	Ssm	15	402	3.7%	cbioportal
16	PCLO	Ssm	15	402	3.7%	cbioportal
14	LRP2	Ssm	15	402	3.7%	cbioportal
18	AHNAK2	Ssm	14	402	3.5%	cbioportal
22	SPEN	Ssm	14	402	3.5%	cbioportal
21	FLG	Ssm	14	402	3.5%	cbioportal
20	DST	Ssm	14	402	3.5%	cbioportal
19	ARID1A	Ssm	14	402	3.5%	cbioportal
28	NEB	Ssm	13	402	3.2%	cbioportal
29	PKHD1L1	Ssm	13	402	3.2%	cbioportal
30	USH2A	Ssm	13	402	3.2%	cbioportal
23	ABCA13	Ssm	13	402	3.2%	cbioportal
24	ATM	Ssm	13	402	3.2%	cbioportal
25	DNAH2	Ssm	13	402	3.2%	cbioportal
26	LRP1B	Ssm	13	402	3.2%	cbioportal
27	MUC17	Ssm	13	402	3.2%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Kidney Renal Papillary Cell Carcinoma TCGA-KIRPTCGA

291 cases with simple somatic mutation data · 291 cases total · Data Release 46.0 · mapped to Papillary Renal Cell Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
3	MED13	Ssm	187	291	64.3%	gdc
1	HELZ	Ssm	187	291	64.3%	gdc
2	MRC2	Ssm	187	291	64.3%	gdc
4	RNF213	Ssm	187	291	64.3%	gdc
5	CCDC57	Ssm	186	291	63.9%	gdc
6	TEX2	Ssm	186	291	63.9%	gdc
7	ACE	Ssm	186	291	63.9%	gdc
8	CLTC	Ssm	186	291	63.9%	gdc
9	UBE2O	Ssm	186	291	63.9%	gdc
10	KCNH6	Ssm	186	291	63.9%	gdc
11	BPTF	Ssm	186	291	63.9%	gdc
12	USP32	Ssm	186	291	63.9%	gdc
13	EFCAB3	Ssm	185	291	63.6%	gdc
30	TBX4	Ssm	185	291	63.6%	gdc
29	PPM1D	Ssm	185	291	63.6%	gdc
28	DCAF7	Ssm	185	291	63.6%	gdc
27	TMC6	Ssm	185	291	63.6%	gdc
26	NOL11	Ssm	185	291	63.6%	gdc
25	AC127029.3	Ssm	185	291	63.6%	gdc
24	NPTX1	Ssm	185	291	63.6%	gdc
23	KCNJ16	Ssm	185	291	63.6%	gdc
22	KIF19	Ssm	185	291	63.6%	gdc
21	TNRC6C	Ssm	185	291	63.6%	gdc
20	UNC13D	Ssm	185	291	63.6%	gdc
19	GNA13	Ssm	185	291	63.6%	gdc
18	RNF157	Ssm	185	291	63.6%	gdc
17	TBCD	Ssm	185	291	63.6%	gdc
16	POLG2	Ssm	185	291	63.6%	gdc
15	QRICH2	Ssm	185	291	63.6%	gdc
14	LRRC37A3	Ssm	185	291	63.6%	gdc

Data updated 23 days agoSource updated Data Release 46.0

Kidney Renal Papillary Cell Carcinoma (TCGA, Firehose Legacy) kirp_tcgaTCGA

282 cases with simple somatic mutation data · 293 cases total · 2026-01-07 · mapped to Papillary Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	35	282	12.4%	cbioportal
2	MUC16	Ssm	24	282	8.5%	cbioportal
3	MET	Ssm	21	282	7.4%	cbioportal
4	KMT2C	Ssm	18	282	6.4%	cbioportal
7	SETD2	Ssm	16	282	5.7%	cbioportal
6	KIF1A	Ssm	16	282	5.7%	cbioportal
5	BLTP1	Ssm	16	282	5.7%	cbioportal
8	MUC4	Ssm	15	282	5.3%	cbioportal
10	KMT2D	Ssm	14	282	5%	cbioportal
9	BAP1	Ssm	14	282	5%	cbioportal
13	PKHD1	Ssm	13	282	4.6%	cbioportal
11	AR	Ssm	13	282	4.6%	cbioportal
12	OBSCN	Ssm	13	282	4.6%	cbioportal
19	WDFY3	Ssm	12	282	4.3%	cbioportal
14	CUBN	Ssm	12	282	4.3%	cbioportal
15	DNAH8	Ssm	12	282	4.3%	cbioportal
16	FAT1	Ssm	12	282	4.3%	cbioportal
17	NEFH	Ssm	12	282	4.3%	cbioportal
18	PCLO	Ssm	12	282	4.3%	cbioportal
20	LRP2	Ssm	11	282	3.9%	cbioportal
24	SYNE1	Ssm	11	282	3.9%	cbioportal
23	PCF11	Ssm	11	282	3.9%	cbioportal
22	PBRM1	Ssm	11	282	3.9%	cbioportal
21	MUC2	Ssm	11	282	3.9%	cbioportal
26	HELZ2	Ssm	10	282	3.5%	cbioportal
25	CUL3	Ssm	10	282	3.5%	cbioportal
29	SMARCA4	Ssm	10	282	3.5%	cbioportal
28	NF2	Ssm	10	282	3.5%	cbioportal
27	KDM6A	Ssm	10	282	3.5%	cbioportal
30	ADGRV1	Ssm	9	282	3.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Kidney Renal Papillary Cell Carcinoma (TCGA, PanCancer Atlas) kirp_tcga_pan_can_atlas_2018TCGA

276 cases with simple somatic mutation data · 283 cases total · 2026-06-05 · mapped to Papillary Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	51	276	18.5%	cbioportal
2	MUC16	Ssm	27	276	9.8%	cbioportal
3	MET	Ssm	22	276	8%	cbioportal
4	BLTP1	Ssm	19	276	6.9%	cbioportal
5	KMT2C	Ssm	19	276	6.9%	cbioportal
7	OBSCN	Ssm	18	276	6.5%	cbioportal
8	PKHD1	Ssm	18	276	6.5%	cbioportal
6	KMT2D	Ssm	18	276	6.5%	cbioportal
10	SETD2	Ssm	17	276	6.2%	cbioportal
9	MACF1	Ssm	17	276	6.2%	cbioportal
11	FAT1	Ssm	16	276	5.8%	cbioportal
12	USH2A	Ssm	15	276	5.4%	cbioportal
15	WDFY3	Ssm	14	276	5.1%	cbioportal
13	BAP1	Ssm	14	276	5.1%	cbioportal
14	DNAH8	Ssm	14	276	5.1%	cbioportal
21	SYNE1	Ssm	13	276	4.7%	cbioportal
19	HUWE1	Ssm	13	276	4.7%	cbioportal
18	HERC2	Ssm	13	276	4.7%	cbioportal
17	DNAH1	Ssm	13	276	4.7%	cbioportal
16	CUBN	Ssm	13	276	4.7%	cbioportal
20	SRRM2	Ssm	13	276	4.7%	cbioportal
22	UBR4	Ssm	13	276	4.7%	cbioportal
28	NEB	Ssm	12	276	4.3%	cbioportal
27	MDN1	Ssm	12	276	4.3%	cbioportal
26	DST	Ssm	12	276	4.3%	cbioportal
25	CENPF	Ssm	12	276	4.3%	cbioportal
30	SYNE2	Ssm	12	276	4.3%	cbioportal
23	ARID1A	Ssm	12	276	4.3%	cbioportal
24	BIRC6	Ssm	12	276	4.3%	cbioportal
29	PBRM1	Ssm	12	276	4.3%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Metastatic Renal Clear Cell Carcinoma (Phase 1 Biomarker Trial, Clin Cancer Res. 2016) - iAtlas Harmonized ccrcc_iatlas_choueiri_2016

16 cases with simple somatic mutation data · 16 cases total · 2026-02-16 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SETD2	Ssm	10	16	62.5%	cbioportal
2	VHL	Ssm	8	16	50%	cbioportal
3	PBRM1	Ssm	6	16	37.5%	cbioportal
6	ZFC3H1	Ssm	4	16	25%	cbioportal
4	BTG4	Ssm	4	16	25%	cbioportal
5	FBXL13	Ssm	4	16	25%	cbioportal
23	VCPIP1	Ssm	3	16	18.8%	cbioportal
7	ARHGAP39	Ssm	3	16	18.8%	cbioportal
8	CENPB	Ssm	3	16	18.8%	cbioportal
9	DMXL2	Ssm	3	16	18.8%	cbioportal
10	FNDC1	Ssm	3	16	18.8%	cbioportal
11	HEATR1	Ssm	3	16	18.8%	cbioportal
12	HUWE1	Ssm	3	16	18.8%	cbioportal
13	LRP2	Ssm	3	16	18.8%	cbioportal
14	MYO10	Ssm	3	16	18.8%	cbioportal
15	PRKDC	Ssm	3	16	18.8%	cbioportal
16	SCUBE2	Ssm	3	16	18.8%	cbioportal
17	SLC9A9	Ssm	3	16	18.8%	cbioportal
18	SPEF2	Ssm	3	16	18.8%	cbioportal
19	SRPK1	Ssm	3	16	18.8%	cbioportal
20	SYNE1	Ssm	3	16	18.8%	cbioportal
21	TTN	Ssm	3	16	18.8%	cbioportal
22	UBR4	Ssm	3	16	18.8%	cbioportal
24	WDR47	Ssm	3	16	18.8%	cbioportal
30	AGBL2	Ssm	2	16	12.5%	cbioportal
25	ABCA5	Ssm	2	16	12.5%	cbioportal
26	ABCC2	Ssm	2	16	12.5%	cbioportal
27	ADAMTS20	Ssm	2	16	12.5%	cbioportal
28	ADAMTSL3	Ssm	2	16	12.5%	cbioportal
29	ADAR	Ssm	2	16	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-02-16

Papillary Renal Cell Carcinoma (TCGA GDC, 2025) prcc_tcga_gdcTCGA GDC

279 cases with simple somatic mutation data · 292 cases total · 2026-01-13 · mapped to Papillary Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	40	279	14.3%	cbioportal
2	MUC16	Ssm	22	279	7.9%	cbioportal
3	MET	Ssm	20	279	7.2%	cbioportal
4	KMT2C	Ssm	18	279	6.5%	cbioportal
6	PKHD1	Ssm	15	279	5.4%	cbioportal
5	BLTP1	Ssm	15	279	5.4%	cbioportal
7	SETD2	Ssm	15	279	5.4%	cbioportal
9	CUBN	Ssm	14	279	5%	cbioportal
8	BAP1	Ssm	14	279	5%	cbioportal
10	FAT1	Ssm	14	279	5%	cbioportal
12	SYNE1	Ssm	13	279	4.7%	cbioportal
11	KMT2D	Ssm	13	279	4.7%	cbioportal
13	USH2A	Ssm	13	279	4.7%	cbioportal
16	SYNE2	Ssm	12	279	4.3%	cbioportal
14	DNAH8	Ssm	12	279	4.3%	cbioportal
15	HERC2	Ssm	12	279	4.3%	cbioportal
17	WDFY3	Ssm	12	279	4.3%	cbioportal
21	PBRM1	Ssm	11	279	3.9%	cbioportal
18	ARID1A	Ssm	11	279	3.9%	cbioportal
19	LRP2	Ssm	11	279	3.9%	cbioportal
20	OBSCN	Ssm	11	279	3.9%	cbioportal
22	PCF11	Ssm	11	279	3.9%	cbioportal
25	MACF1	Ssm	10	279	3.6%	cbioportal
23	CUL3	Ssm	10	279	3.6%	cbioportal
24	KDM6A	Ssm	10	279	3.6%	cbioportal
26	SRRM2	Ssm	10	279	3.6%	cbioportal
30	HERC1	Ssm	9	279	3.2%	cbioportal
29	BIRC6	Ssm	9	279	3.2%	cbioportal
28	ANK3	Ssm	9	279	3.2%	cbioportal
27	ADGRV1	Ssm	9	279	3.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Renal Cell Carcinoma (CPTAC GDC, 2025) rcc_cptac_gdcCPTAC GDC

352 cases with simple somatic mutation data · 354 cases total · 2026-01-14 · mapped to Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	237	352	67.3%	cbioportal
2	PBRM1	Ssm	114	352	32.4%	cbioportal
3	BAP1	Ssm	48	352	13.6%	cbioportal
4	TTN	Ssm	44	352	12.5%	cbioportal
5	KDM5C	Ssm	43	352	12.2%	cbioportal
6	SETD2	Ssm	39	352	11.1%	cbioportal
7	CSMD3	Ssm	34	352	9.7%	cbioportal
8	MTOR	Ssm	23	352	6.5%	cbioportal
9	LRP2	Ssm	20	352	5.7%	cbioportal
10	MUC16	Ssm	20	352	5.7%	cbioportal
12	USH2A	Ssm	19	352	5.4%	cbioportal
11	RYR2	Ssm	19	352	5.4%	cbioportal
13	CUBN	Ssm	18	352	5.1%	cbioportal
14	MUC17	Ssm	17	352	4.8%	cbioportal
15	YLPM1	Ssm	17	352	4.8%	cbioportal
17	SYNE1	Ssm	16	352	4.5%	cbioportal
16	HMCN1	Ssm	16	352	4.5%	cbioportal
19	ZNF292	Ssm	16	352	4.5%	cbioportal
18	SYNE2	Ssm	16	352	4.5%	cbioportal
21	FSIP2	Ssm	15	352	4.3%	cbioportal
20	DST	Ssm	15	352	4.3%	cbioportal
23	SI	Ssm	15	352	4.3%	cbioportal
22	MACF1	Ssm	15	352	4.3%	cbioportal
26	DNAH5	Ssm	14	352	4%	cbioportal
24	APOB	Ssm	14	352	4%	cbioportal
27	PKD1	Ssm	14	352	4%	cbioportal
25	BIRC6	Ssm	14	352	4%	cbioportal
30	MAP1A	Ssm	13	352	3.7%	cbioportal
29	LRTM3	Ssm	13	352	3.7%	cbioportal
28	GOLGB1	Ssm	13	352	3.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Renal Cell Carcinoma (IMmotion150 Clinical Trial, Nat Med. 2018) - iAtlas Harmonized rcc_iatlas_immotion150_2018

158 cases with simple somatic mutation data · 263 cases total · 2026-02-11 · mapped to Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	106	158	67.1%	cbioportal
2	PBRM1	Ssm	79	158	50%	cbioportal
3	TTN	Ssm	67	158	42.4%	cbioportal
4	MUC16	Ssm	60	158	38%	cbioportal
5	AHNAK2	Ssm	56	158	35.4%	cbioportal
6	SETD2	Ssm	52	158	32.9%	cbioportal
7	OBSCN	Ssm	51	158	32.3%	cbioportal
8	HSPG2	Ssm	48	158	30.4%	cbioportal
9	KMT2D	Ssm	46	158	29.1%	cbioportal
10	LRP1	Ssm	45	158	28.5%	cbioportal
12	MUC5B	Ssm	44	158	27.8%	cbioportal
11	BSN	Ssm	44	158	27.8%	cbioportal
13	ZNF469	Ssm	41	158	25.9%	cbioportal
14	ZNF594	Ssm	40	158	25.3%	cbioportal
15	COL7A1	Ssm	39	158	24.7%	cbioportal
16	LAMA5	Ssm	39	158	24.7%	cbioportal
21	PLEC	Ssm	38	158	24.1%	cbioportal
20	OTOG	Ssm	38	158	24.1%	cbioportal
19	MUC5AC	Ssm	38	158	24.1%	cbioportal
18	FLNA	Ssm	38	158	24.1%	cbioportal
17	AHNAK	Ssm	38	158	24.1%	cbioportal
22	DNAH1	Ssm	37	158	23.4%	cbioportal
23	RYR1	Ssm	37	158	23.4%	cbioportal
24	SYNE1	Ssm	37	158	23.4%	cbioportal
27	PLXNB3	Ssm	36	158	22.8%	cbioportal
25	IRF2BPL	Ssm	36	158	22.8%	cbioportal
26	KIF1A	Ssm	36	158	22.8%	cbioportal
28	SPEG	Ssm	35	158	22.2%	cbioportal
29	ADGRV1	Ssm	34	158	21.5%	cbioportal
30	CACNA1H	Ssm	34	158	21.5%	cbioportal

Data updated 22 days agoSource updated 2026-02-11

Renal Cell Carcinoma (St. James, Clin Cancer Res 2023) ccrcc_sjuh_2023St. James

943 cases with simple somatic mutation data · 943 cases total · 2026-03-09 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved12 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	642	943	68.1%	cbioportal
2	PBRM1	Ssm	325	943	34.5%	cbioportal
3	SETD2	Ssm	151	943	16%	cbioportal
4	BAP1	Ssm	119	943	12.6%	cbioportal
5	KDM5C	Ssm	67	943	7.1%	cbioportal
6	ATM	Ssm	31	943	3.3%	cbioportal
7	DMD	Ssm	29	943	3.1%	cbioportal
8	TP53	Ssm	29	943	3.1%	cbioportal
9	COL11A1	Ssm	21	943	2.2%	cbioportal
10	TRRAP	Ssm	12	943	1.3%	cbioportal
11	PTK7	Ssm	6	943	0.6%	cbioportal
12	ATP9B	Ssm	5	943	0.5%	cbioportal

Data updated 22 days agoSource updated 2026-03-09

Renal Clear Cell Carcinoma (TCGA GDC, 2025) ccrcc_tcga_gdcTCGA GDC

375 cases with simple somatic mutation data · 537 cases total · 2026-01-13 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	172	375	45.9%	cbioportal
2	PBRM1	Ssm	147	375	39.2%	cbioportal
3	TTN	Ssm	63	375	16.8%	cbioportal
4	SETD2	Ssm	46	375	12.3%	cbioportal
5	BAP1	Ssm	40	375	10.7%	cbioportal
6	MUC16	Ssm	29	375	7.7%	cbioportal
7	MTOR	Ssm	27	375	7.2%	cbioportal
8	KDM5C	Ssm	20	375	5.3%	cbioportal
9	DNAH9	Ssm	19	375	5.1%	cbioportal
10	DST	Ssm	19	375	5.1%	cbioportal
11	ATM	Ssm	17	375	4.5%	cbioportal
12	CSMD3	Ssm	17	375	4.5%	cbioportal
15	KMT2C	Ssm	16	375	4.3%	cbioportal
16	LRP2	Ssm	16	375	4.3%	cbioportal
13	FBN2	Ssm	16	375	4.3%	cbioportal
14	HMCN1	Ssm	16	375	4.3%	cbioportal
17	AHNAK2	Ssm	15	375	4%	cbioportal
19	SPEN	Ssm	14	375	3.7%	cbioportal
21	USH2A	Ssm	14	375	3.7%	cbioportal
18	ANK3	Ssm	14	375	3.7%	cbioportal
20	SYNE1	Ssm	14	375	3.7%	cbioportal
23	MUC17	Ssm	13	375	3.5%	cbioportal
24	PCLO	Ssm	13	375	3.5%	cbioportal
25	PTEN	Ssm	13	375	3.5%	cbioportal
22	DNAH2	Ssm	13	375	3.5%	cbioportal
28	LRP1B	Ssm	12	375	3.2%	cbioportal
30	XIRP2	Ssm	12	375	3.2%	cbioportal
26	ARID1A	Ssm	12	375	3.2%	cbioportal
27	FLG	Ssm	12	375	3.2%	cbioportal
29	PKHD1L1	Ssm	12	375	3.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Renal Clear Cell Carcinoma (UTokyo, Nat Genet 2013) ccrcc_utokyo_2013UTokyo

106 cases with simple somatic mutation data · 106 cases total · 2026-01-05 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	43	106	40.6%	cbioportal
2	PBRM1	Ssm	31	106	29.2%	cbioportal
3	TTN	Ssm	21	106	19.8%	cbioportal
4	MUC16	Ssm	15	106	14.2%	cbioportal
5	SETD2	Ssm	12	106	11.3%	cbioportal
6	BAP1	Ssm	9	106	8.5%	cbioportal
7	CSMD3	Ssm	8	106	7.5%	cbioportal
8	AHNAK2	Ssm	7	106	6.6%	cbioportal
14	TET2	Ssm	6	106	5.7%	cbioportal
9	FRYL	Ssm	6	106	5.7%	cbioportal
10	HMCN1	Ssm	6	106	5.7%	cbioportal
11	KMT2C	Ssm	6	106	5.7%	cbioportal
12	MTOR	Ssm	6	106	5.7%	cbioportal
13	MUC4	Ssm	6	106	5.7%	cbioportal
15	ELOC	Ssm	5	106	4.7%	cbioportal
19	PKHD1	Ssm	5	106	4.7%	cbioportal
18	PIK3CA	Ssm	5	106	4.7%	cbioportal
17	KEAP1	Ssm	5	106	4.7%	cbioportal
16	KCNMA1	Ssm	5	106	4.7%	cbioportal
20	ZNF536	Ssm	5	106	4.7%	cbioportal
30	IQGAP2	Ssm	4	106	3.8%	cbioportal
24	CUBN	Ssm	4	106	3.8%	cbioportal
25	DNAH11	Ssm	4	106	3.8%	cbioportal
26	DNAH3	Ssm	4	106	3.8%	cbioportal
27	EP300	Ssm	4	106	3.8%	cbioportal
28	GRB7	Ssm	4	106	3.8%	cbioportal
29	HYDIN	Ssm	4	106	3.8%	cbioportal
21	ARHGEF28	Ssm	4	106	3.8%	cbioportal
22	BCL11A	Ssm	4	106	3.8%	cbioportal
23	CACNA1G	Ssm	4	106	3.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Renal Non-Clear Cell Carcinoma (Genentech, Nat Genet 2014) nccrcc_genentech_2014Genentech

146 cases with simple somatic mutation data · 146 cases total · 2026-01-08 · mapped to Renal Non-Clear Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	17	146	11.6%	cbioportal
2	TP53	Ssm	11	146	7.5%	cbioportal
3	MET	Ssm	10	146	6.8%	cbioportal
4	MUC4	Ssm	9	146	6.2%	cbioportal
5	MACF1	Ssm	7	146	4.8%	cbioportal
6	PCLO	Ssm	7	146	4.8%	cbioportal
8	LRP2	Ssm	6	146	4.1%	cbioportal
7	ARID1A	Ssm	6	146	4.1%	cbioportal
9	SPEN	Ssm	6	146	4.1%	cbioportal
12	MUC16	Ssm	5	146	3.4%	cbioportal
17	STARD9	Ssm	5	146	3.4%	cbioportal
16	SETD2	Ssm	5	146	3.4%	cbioportal
15	PTEN	Ssm	5	146	3.4%	cbioportal
14	OBSCN	Ssm	5	146	3.4%	cbioportal
13	MUC6	Ssm	5	146	3.4%	cbioportal
11	KMT2C	Ssm	5	146	3.4%	cbioportal
10	FREM2	Ssm	5	146	3.4%	cbioportal
30	FAT2	Ssm	4	146	2.7%	cbioportal
18	ADGRV1	Ssm	4	146	2.7%	cbioportal
19	AHNAK	Ssm	4	146	2.7%	cbioportal
21	APC	Ssm	4	146	2.7%	cbioportal
22	ARID1B	Ssm	4	146	2.7%	cbioportal
20	ANK3	Ssm	4	146	2.7%	cbioportal
23	BIRC6	Ssm	4	146	2.7%	cbioportal
24	BLTP1	Ssm	4	146	2.7%	cbioportal
25	CACNA1C	Ssm	4	146	2.7%	cbioportal
26	CEP295	Ssm	4	146	2.7%	cbioportal
27	CUBN	Ssm	4	146	2.7%	cbioportal
28	DNAH5	Ssm	4	146	2.7%	cbioportal
29	ERCC2	Ssm	4	146	2.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Unclassified Renal Cell Carcinoma (MSK, Nature 2016) urcc_mskcc_2016MSK

62 cases with simple somatic mutation data · 62 cases total · 2026-01-16 · mapped to Unclassified Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NF2	Ssm	11	62	17.7%	cbioportal
2	SETD2	Ssm	11	62	17.7%	cbioportal
3	BAP1	Ssm	8	62	12.9%	cbioportal
4	KMT2C	Ssm	6	62	9.7%	cbioportal
5	MTOR	Ssm	5	62	8.1%	cbioportal
6	ATRX	Ssm	4	62	6.5%	cbioportal
7	PTEN	Ssm	4	62	6.5%	cbioportal
8	TSC1	Ssm	4	62	6.5%	cbioportal
14	SMARCB1	Ssm	3	62	4.8%	cbioportal
9	DNMT3A	Ssm	3	62	4.8%	cbioportal
10	FH	Ssm	3	62	4.8%	cbioportal
11	KLF6	Ssm	3	62	4.8%	cbioportal
12	KMT2D	Ssm	3	62	4.8%	cbioportal
13	NOTCH2	Ssm	3	62	4.8%	cbioportal
15	TP53	Ssm	3	62	4.8%	cbioportal
16	TSC2	Ssm	3	62	4.8%	cbioportal
27	RPTOR	Ssm	2	62	3.2%	cbioportal
18	EPHA6	Ssm	2	62	3.2%	cbioportal
19	GNAS	Ssm	2	62	3.2%	cbioportal
20	IRS1	Ssm	2	62	3.2%	cbioportal
21	KDM6A	Ssm	2	62	3.2%	cbioportal
22	KMT2A	Ssm	2	62	3.2%	cbioportal
23	MLST8	Ssm	2	62	3.2%	cbioportal
28	SUFU	Ssm	2	62	3.2%	cbioportal
26	RICTOR	Ssm	2	62	3.2%	cbioportal
17	CHEK2	Ssm	2	62	3.2%	cbioportal
24	PBRM1	Ssm	2	62	3.2%	cbioportal
25	PRKN	Ssm	2	62	3.2%	cbioportal
30	ABL2	Ssm	1	62	1.6%	cbioportal
29	ABL1	Ssm	1	62	1.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16