Irinotecan

Curated

← predicts response to

TOP1 Amplificationamplification

sensitivity

Curated

← predicts response to

VEGFA Decreased Peri-therapeutic Expressionexpression

sensitivity

Curated

← predicts response to

BRAF V600

sensitivity

Curated

← predicts response to

BRAF D594KSNV

resistance

Curated

← predicts response to

BRAF Mutationother

resistance

Curated

← predicts response to

BRAF V600ESNV

resistance

Curated

← predicts response to

TOP1 EXPRESSIONexpression

sensitivity

Curated

← predicts response to

DKK1 NUCLEAR EXPRESSIONexpression

resistance

Curated

← predicts response to

TYMS 3TRP/3TRP genotype

resistance

Curated

← predicts response to

BRAF V600ESNV

sensitivity

Curated

← predicts response to

BRAF V600ESNV

2 source records aggregated

resistance

Curated

← predicts response to

NRAS G13RSNV

resistance

Curated

← predicts response to

ARAF S490TSNV

resistance

Curated

← predicts response to

NRAS Q61HSNV

resistance

Curated

Irinotecan targets …TARGETS1 of 1
→ targets	TOP1	—	INHIBITOR	—	1	Curated	chembl	graph →

Irinotecan targets …TARGETS1 of 1

→ targets

TOP1

—

INHIBITOR

—

Curated

Irinotecan investigated for …INVESTIGATED_FOR98 of 98show fewer
→ investigated for	Malignant Colorectal Neoplasmsubtype 11 source records aggregated	supports	B	Malignant Colorectal Neoplasm	11	Curated	civic	graph →
→ investigated for	Adenocarcinomahistology	unknown	4	Adenocarcinoma	1	Curated	chembl	graph →
→ investigated for	Pancreatic Neoplasmsubtype	unknown	4	Pancreatic Neoplasm	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Carcinomacancer_family	unknown	4	Carcinoma	1	Curated	chembl	graph →
→ investigated for	Malignant Colorectal Neoplasmsubtype 12 source records aggregated	supports	C	Malignant Colorectal Neoplasm	12	Curated	civic	graph →
→ investigated for	Cholangiocarcinomasubtype	supports	C	Cholangiocarcinoma	1	Curated	civic	graph →
→ investigated for	Ureter Small Cell Neuroendocrine Carcinomasubtype	supports	C	Ureter Small Cell Neuroendocrine Carcinoma	1	Curated	civic	graph →
→ investigated for	Lung Small Cell Carcinomasubtype	supports	C	Lung Small Cell Carcinoma	1	Curated	civic	graph →
→ investigated for	Choroid Plexus Neoplasmcancer	unknown	3	Choroid Plexus Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Neoplasmcancer_family	unknown	3	Lung Neoplasm	1	Curated	chembl	graph →
→ investigated for	Neuroendocrine Carcinomasubtype	unknown	3	Neuroendocrine Carcinoma	1	Curated	chembl	graph →
→ investigated for	Ganglioneuroblastomasubtype	unknown	3	Ganglioneuroblastoma	1	Curated	chembl	graph →
→ investigated for	Hepatoblastomacancer_family	unknown	3	Hepatoblastoma	1	Curated	chembl	graph →
→ investigated for	Embryonal Rhabdomyosarcomasubtype	unknown	3	Embryonal Rhabdomyosarcoma	1	Curated	chembl	graph →
→ investigated for	Alveolar Rhabdomyosarcomasubtype	unknown	3	Alveolar Rhabdomyosarcoma	1	Curated	chembl	graph →
→ investigated for	Rectal Neoplasmsubtype	unknown	3	Rectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Cholangiocarcinomasubtype	unknown	3	Cholangiocarcinoma	1	Curated	chembl	graph →
→ investigated for	Colon Neoplasmsubtype	unknown	3	Colon Neoplasm	1	Curated	chembl	graph →
→ investigated for	Breast Neoplasmcancer_family	unknown	3	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Brain Neoplasmsubtype	unknown	3	Brain Neoplasm	1	Curated	chembl	graph →
→ investigated for	Esophageal Neoplasmcancer_family	unknown	3	Esophageal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Cervical Neoplasmsubtype	unknown	3	Cervical Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Small Cell Carcinomasubtype	unknown	3	Lung Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Sarcomacancer_family	unknown	3	Sarcoma	1	Curated	chembl	graph →
→ investigated for	Neuroblastomasubtype	unknown	3	Neuroblastoma	1	Curated	chembl	graph →
→ investigated for	Colorectal Neoplasmsubtype	unknown	3	Colorectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Gastric Neoplasmcancer_family	unknown	3	Gastric Neoplasm	1	Curated	chembl	graph →
→ investigated for	Ewing Sarcomasubtype	unknown	3	Ewing Sarcoma	1	Curated	chembl	graph →
→ investigated for	Hepatocellular Carcinomasubtype	unknown	3	Hepatocellular Carcinoma	1	Curated	chembl	graph →
→ investigated for	Malignant Colorectal Neoplasmsubtype 2 source records aggregated	supports	D	Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ investigated for	Bile Duct Neoplasmsubtype	unknown	2	Bile Duct Neoplasm	1	Curated	chembl	graph →
→ investigated for	Neuroendocrine Tumorsubtype	unknown	2	Neuroendocrine Tumor	1	Curated	chembl	graph →
→ investigated for	Paragangliomasubtype	unknown	2	Paraganglioma	1	Curated	chembl	graph →
→ investigated for	Bone Neoplasmsubtype	unknown	2	Bone Neoplasm	1	Curated	chembl	graph →
→ investigated for	Peripheral Primitive Neuroectodermal Tumorsubtype	unknown	2	Peripheral Primitive Neuroectodermal Tumor	1	Curated	chembl	graph →
→ investigated for	Wilms Tumorcancer_family	unknown	2	Wilms Tumor	1	Curated	chembl	graph →
→ investigated for	Pancreatic Neuroendocrine Carcinomasubtype	unknown	2	Pancreatic Neuroendocrine Carcinoma	1	Curated	chembl	graph →
→ investigated for	Angiosarcomasubtype	unknown	2	Angiosarcoma	1	Curated	chembl	graph →
→ investigated for	Meningiomasubtype	unknown	2	Meningioma	1	Curated	chembl	graph →
→ investigated for	Gallbladder Neoplasmsubtype	unknown	2	Gallbladder Neoplasm	1	Curated	chembl	graph →
→ investigated for	Urethra Neoplasmsubtype	unknown	2	Urethra Neoplasm	1	Curated	chembl	graph →
→ investigated for	Liver Neoplasmsubtype	unknown	2	Liver Neoplasm	1	Curated	chembl	graph →
→ investigated for	Kidney Neoplasmsubtype	unknown	2	Kidney Neoplasm	1	Curated	chembl	graph →
→ investigated for	Peritoneal Neoplasmcancer_family	unknown	2	Peritoneal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Fallopian Tube Neoplasmsubtype	unknown	2	Fallopian Tube Neoplasm	1	Curated	chembl	graph →
→ investigated for	Bladder Neoplasmsubtype	unknown	2	Bladder Neoplasm	1	Curated	chembl	graph →
→ investigated for	Penile Neoplasmsubtype	unknown	2	Penile Neoplasm	1	Curated	chembl	graph →
→ investigated for	Central Nervous System Neoplasmcancer_family	unknown	2	Central Nervous System Neoplasm	1	Curated	chembl	graph →
→ investigated for	Ovarian Neoplasmsubtype	unknown	2	Ovarian Neoplasm	1	Curated	chembl	graph →
→ investigated for	Merkel Cell Carcinomasubtype	unknown	2	Merkel Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Head and Neck Neoplasmcancer_family	unknown	2	Head and Neck Neoplasm	1	Curated	chembl	graph →
→ investigated for	Osteosarcomasubtype	unknown	2	Osteosarcoma	1	Curated	chembl	graph →
→ investigated for	Gliosarcomasubtype	unknown	2	Gliosarcoma	1	Curated	chembl	graph →
→ investigated for	Non-Hodgkin Lymphomahematologic_malignancy	unknown	2	Non-Hodgkin Lymphoma	1	Curated	chembl	graph →
→ investigated for	Pineal Region Neoplasmsubtype	unknown	2	Pineal Region Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	2	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Medulloblastomasubtype	unknown	2	Medulloblastoma	1	Curated	chembl	graph →
→ investigated for	Rhabdomyosarcomasubtype	unknown	2	Rhabdomyosarcoma	1	Curated	chembl	graph →
→ investigated for	Astrocytic Tumorsubtype	unknown	2	Astrocytic Tumor	1	Curated	chembl	graph →
→ investigated for	Oligodendrogliomasubtype	unknown	2	Oligodendroglioma	1	Curated	chembl	graph →
→ investigated for	Squamous Cell Carcinomahistology	unknown	2	Squamous Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Leukemiacancer_family	unknown	2	Leukemia	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	2	Lymphoma	1	Curated	chembl	graph →
→ investigated for	Glioblastomasubtype	unknown	2	Glioblastoma	1	Curated	chembl	graph →
→ investigated for	Gliomasubtype	unknown	2	Glioma	1	Curated	chembl	graph →
→ investigated for	Digestive System Neoplasmcancer_family	unknown	1	Digestive System Neoplasm	1	Curated	chembl	graph →
→ investigated for	Ovarian Carcinomasubtype	unknown	1	Ovarian Carcinoma	1	Curated	chembl	graph →
→ investigated for	Gastrointestinal Stromal Tumorsubtype	unknown	1	Gastrointestinal Stromal Tumor	1	Curated	chembl	graph →
→ investigated for	Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissuehematologic_malignancy	unknown	1	Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue	1	Curated	chembl	graph →
→ investigated for	Melanomacancer_family	unknown	1	Melanoma	1	Curated	chembl	graph →
→ investigated for	Head and Neck Squamous Cell Carcinomasubtype	unknown	1	Head and Neck Squamous Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Diffuse Intrinsic Pontine Gliomasubtype	unknown	1	Diffuse Intrinsic Pontine Glioma	1	Curated	chembl	graph →
→ investigated for	Malignant Mesotheliomacancer_family	unknown	1	Malignant Mesothelioma	1	Curated	chembl	graph →
→ investigated for	Oropharyngeal Neoplasmsubtype	unknown	1	Oropharyngeal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Adult T-Cell Leukemia/Lymphomahematologic_malignancy	unknown	1	Adult T-Cell Leukemia/Lymphoma	1	Curated	chembl	graph →
→ investigated for	Follicular Lymphomahematologic_malignancy	unknown	1	Follicular Lymphoma	1	Curated	chembl	graph →
→ investigated for	Salivary Gland Neoplasmcancer_family	unknown	1	Salivary Gland Neoplasm	1	Curated	chembl	graph →
→ investigated for	Appendix Neoplasmcancer_family	unknown	1	Appendix Neoplasm	1	Curated	chembl	graph →
→ investigated for	Inverted Papillomahistology	unknown	1	Inverted Papilloma	1	Curated	chembl	graph →
→ investigated for	Anal Neoplasmsubtype	unknown	1	Anal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Acute Lymphoblastic Leukemiahematologic_malignancy	unknown	1	Acute Lymphoblastic Leukemia	1	Curated	chembl	graph →
→ investigated for	Hypopharyngeal Neoplasmsubtype	unknown	1	Hypopharyngeal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Endometrial Neoplasmsubtype	unknown	1	Endometrial Neoplasm	1	Curated	chembl	graph →
→ investigated for	AIDS-Related Lymphomahematologic_malignancy	unknown	1	AIDS-Related Lymphoma	1	Curated	chembl	graph →
→ investigated for	Mantle Cell Lymphomahematologic_malignancy	unknown	1	Mantle Cell Lymphoma	1	Curated	chembl	graph →
→ investigated for	Mycosis Fungoideshematologic_malignancy	unknown	1	Mycosis Fungoides	1	Curated	chembl	graph →
→ investigated for	Olfactory Neuroblastomasubtype	unknown	1	Olfactory Neuroblastoma	1	Curated	chembl	graph →
→ investigated for	Sezary Syndromehematologic_malignancy	unknown	1	Sezary Syndrome	1	Curated	chembl	graph →
→ investigated for	Verrucous Carcinomahistology	unknown	1	Verrucous Carcinoma	1	Curated	chembl	graph →
→ investigated for	Triple-Negative Breast Carcinomamolecular_subtype	unknown	1	Triple-Negative Breast Carcinoma	1	Curated	chembl	graph →
→ investigated for	Anaplastic Large Cell Lymphomahematologic_malignancy	unknown	1	Anaplastic Large Cell Lymphoma	1	Curated	chembl	graph →
→ investigated for	Basal Cell Carcinomahistology	unknown	1	Basal Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Burkitt Lymphomahematologic_malignancy	unknown	1	Burkitt Lymphoma	1	Curated	chembl	graph →
→ investigated for	Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Typehematologic_malignancy	unknown	1	Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type	1	Curated	chembl	graph →
→ investigated for	Hodgkin Lymphomahematologic_malignancy	unknown	1	Hodgkin Lymphoma	1	Curated	chembl	graph →
→ investigated for	Chronic Lymphocytic Leukemiahematologic_malignancy	unknown	1	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
→ investigated for	Desmoplastic Small Round Cell Tumorsubtype	unknown	0.5	Desmoplastic Small Round Cell Tumor	1	Curated	chembl	graph →

Irinotecan investigated for …INVESTIGATED_FOR98 of 98show fewer

→ investigated for

11 source records aggregated

supports

Curated

→ investigated for

Adenocarcinomahistology

unknown

Adenocarcinoma

Curated

→ investigated for

Pancreatic Neoplasmsubtype

unknown

Pancreatic Neoplasm

Curated

→ investigated for

Neoplasmcancer_family

unknown

Neoplasm

Curated

→ investigated for

Carcinomacancer_family

unknown

Carcinoma

Curated

→ investigated for

12 source records aggregated

supports

Curated

→ investigated for

Cholangiocarcinomasubtype

supports

Cholangiocarcinoma

Curated

Ureter Small Cell Neuroendocrine Carcinoma

→ investigated for

Ureter Small Cell Neuroendocrine Carcinomasubtype

supports

Curated

Lung Small Cell Carcinoma

→ investigated for

Lung Small Cell Carcinomasubtype

supports

Curated

→ investigated for

Choroid Plexus Neoplasmcancer

unknown

Choroid Plexus Neoplasm

Curated

→ investigated for

Lung Neoplasmcancer_family

unknown

Lung Neoplasm

Curated

→ investigated for

Neuroendocrine Carcinomasubtype

unknown

Neuroendocrine Carcinoma

Curated

→ investigated for

Ganglioneuroblastomasubtype

unknown

Ganglioneuroblastoma

Curated

→ investigated for

Hepatoblastomacancer_family

unknown

Hepatoblastoma

Curated

Embryonal Rhabdomyosarcoma

→ investigated for

Embryonal Rhabdomyosarcomasubtype

unknown

Curated

Alveolar Rhabdomyosarcoma

→ investigated for

Alveolar Rhabdomyosarcomasubtype

unknown

Curated

→ investigated for

Rectal Neoplasmsubtype

unknown

Rectal Neoplasm

Curated

→ investigated for

Cholangiocarcinomasubtype

unknown

Cholangiocarcinoma

Curated

→ investigated for

Colon Neoplasmsubtype

unknown

Colon Neoplasm

Curated

→ investigated for

Breast Neoplasmcancer_family

unknown

Breast Neoplasm

Curated

→ investigated for

Brain Neoplasmsubtype

unknown

Brain Neoplasm

Curated

→ investigated for

Esophageal Neoplasmcancer_family

unknown

Esophageal Neoplasm

Curated

→ investigated for

Cervical Neoplasmsubtype

unknown

Cervical Neoplasm

Curated

Lung Small Cell Carcinoma

→ investigated for

Lung Small Cell Carcinomasubtype

unknown

Curated

→ investigated for

Sarcomacancer_family

unknown

Sarcoma

Curated

→ investigated for

Neuroblastomasubtype

unknown

Neuroblastoma

Curated

→ investigated for

Colorectal Neoplasmsubtype

unknown

Curated

→ investigated for

Gastric Neoplasmcancer_family

unknown

Gastric Neoplasm

Curated

→ investigated for

Ewing Sarcomasubtype

unknown

Ewing Sarcoma

Curated

→ investigated for

Hepatocellular Carcinomasubtype

unknown

Hepatocellular Carcinoma

Curated

→ investigated for

2 source records aggregated

supports

Curated

→ investigated for

Bile Duct Neoplasmsubtype

unknown

Bile Duct Neoplasm

Curated

→ investigated for

Neuroendocrine Tumorsubtype

unknown

Neuroendocrine Tumor

Curated

→ investigated for

Paragangliomasubtype

unknown

Paraganglioma

Curated

→ investigated for

Bone Neoplasmsubtype

unknown

Bone Neoplasm

Curated

Peripheral Primitive Neuroectodermal Tumor

→ investigated for

Peripheral Primitive Neuroectodermal Tumorsubtype

unknown

Curated

→ investigated for

Wilms Tumorcancer_family

unknown

Wilms Tumor

Curated

Pancreatic Neuroendocrine Carcinoma

→ investigated for

Pancreatic Neuroendocrine Carcinomasubtype

unknown

Curated

→ investigated for

Angiosarcomasubtype

unknown

Angiosarcoma

Curated

→ investigated for

Meningiomasubtype

unknown

Meningioma

Curated

→ investigated for

Gallbladder Neoplasmsubtype

unknown

Gallbladder Neoplasm

Curated

→ investigated for

Urethra Neoplasmsubtype

unknown

Urethra Neoplasm

Curated

→ investigated for

Liver Neoplasmsubtype

unknown

Liver Neoplasm

Curated

→ investigated for

Kidney Neoplasmsubtype

unknown

Kidney Neoplasm

Curated

→ investigated for

Peritoneal Neoplasmcancer_family

unknown

Peritoneal Neoplasm

Curated

→ investigated for

Fallopian Tube Neoplasmsubtype

unknown

Fallopian Tube Neoplasm

Curated

→ investigated for

Bladder Neoplasmsubtype

unknown

Bladder Neoplasm

Curated

→ investigated for

Penile Neoplasmsubtype

unknown

Penile Neoplasm

Curated

Central Nervous System Neoplasm

→ investigated for

Central Nervous System Neoplasmcancer_family

unknown

Curated

→ investigated for

Ovarian Neoplasmsubtype

unknown

Ovarian Neoplasm

Curated

→ investigated for

Merkel Cell Carcinomasubtype

unknown

Merkel Cell Carcinoma

Curated

→ investigated for

Head and Neck Neoplasmcancer_family

unknown

Head and Neck Neoplasm

Curated

→ investigated for

Osteosarcomasubtype

unknown

Osteosarcoma

Curated

→ investigated for

Gliosarcomasubtype

unknown

Gliosarcoma

Curated

→ investigated for

Non-Hodgkin Lymphomahematologic_malignancy

unknown

Non-Hodgkin Lymphoma

Curated

→ investigated for

Pineal Region Neoplasmsubtype

unknown

Pineal Region Neoplasm

Curated

Lung Non-Small Cell Carcinoma

→ investigated for

Lung Non-Small Cell Carcinomasubtype

unknown

Curated

→ investigated for

Medulloblastomasubtype

unknown

Medulloblastoma

Curated

→ investigated for

Rhabdomyosarcomasubtype

unknown

Rhabdomyosarcoma

Curated

→ investigated for

Astrocytic Tumorsubtype

unknown

Astrocytic Tumor

Curated

→ investigated for

Oligodendrogliomasubtype

unknown

Oligodendroglioma

Curated

→ investigated for

Squamous Cell Carcinomahistology

unknown

Squamous Cell Carcinoma

Curated

→ investigated for

Leukemiacancer_family

unknown

Leukemia

Curated

→ investigated for

Lymphomacancer_family

unknown

Lymphoma

Curated

→ investigated for

Glioblastomasubtype

unknown

Glioblastoma

Curated

→ investigated for

Gliomasubtype

unknown

Glioma

Curated

Digestive System Neoplasm

→ investigated for

Digestive System Neoplasmcancer_family

unknown

Curated

→ investigated for

Ovarian Carcinomasubtype

unknown

Ovarian Carcinoma

Curated

Gastrointestinal Stromal Tumor

→ investigated for

Gastrointestinal Stromal Tumorsubtype

unknown

Curated

Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

→ investigated for

Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissuehematologic_malignancy

unknown

Curated

→ investigated for

Melanomacancer_family

unknown

Melanoma

Curated

Head and Neck Squamous Cell Carcinoma

→ investigated for

Head and Neck Squamous Cell Carcinomasubtype

unknown

Curated

Diffuse Intrinsic Pontine Glioma

→ investigated for

Diffuse Intrinsic Pontine Gliomasubtype

unknown

Curated

→ investigated for

Malignant Mesotheliomacancer_family

unknown

Malignant Mesothelioma

Curated

→ investigated for

Oropharyngeal Neoplasmsubtype

unknown

Oropharyngeal Neoplasm

Curated

Adult T-Cell Leukemia/Lymphoma

→ investigated for

Adult T-Cell Leukemia/Lymphomahematologic_malignancy

unknown

Curated

→ investigated for

Follicular Lymphomahematologic_malignancy

unknown

Follicular Lymphoma

Curated

→ investigated for

Salivary Gland Neoplasmcancer_family

unknown

Salivary Gland Neoplasm

Curated

→ investigated for

Appendix Neoplasmcancer_family

unknown

Appendix Neoplasm

Curated

→ investigated for

Inverted Papillomahistology

unknown

Inverted Papilloma

Curated

→ investigated for

Anal Neoplasmsubtype

unknown

Anal Neoplasm

Curated

Acute Lymphoblastic Leukemia

→ investigated for

Acute Lymphoblastic Leukemiahematologic_malignancy

unknown

Curated

→ investigated for

Hypopharyngeal Neoplasmsubtype

unknown

Hypopharyngeal Neoplasm

Curated

→ investigated for

Endometrial Neoplasmsubtype

unknown

Endometrial Neoplasm

Curated

→ investigated for

AIDS-Related Lymphomahematologic_malignancy

unknown

AIDS-Related Lymphoma

Curated

→ investigated for

Mantle Cell Lymphomahematologic_malignancy

unknown

Mantle Cell Lymphoma

Curated

→ investigated for

Mycosis Fungoideshematologic_malignancy

unknown

Mycosis Fungoides

Curated

→ investigated for

Olfactory Neuroblastomasubtype

unknown

Olfactory Neuroblastoma

Curated

→ investigated for

Sezary Syndromehematologic_malignancy

unknown

Sezary Syndrome

Curated

→ investigated for

Verrucous Carcinomahistology

unknown

Verrucous Carcinoma

Curated

Triple-Negative Breast Carcinoma

→ investigated for

Triple-Negative Breast Carcinomamolecular_subtype

unknown

Curated

Anaplastic Large Cell Lymphoma

→ investigated for

Anaplastic Large Cell Lymphomahematologic_malignancy

unknown

Curated

→ investigated for

Basal Cell Carcinomahistology

unknown

Basal Cell Carcinoma

Curated

→ investigated for

Burkitt Lymphomahematologic_malignancy

unknown

Burkitt Lymphoma

Curated

Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type

→ investigated for

Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Typehematologic_malignancy

unknown

Curated

→ investigated for

Hodgkin Lymphomahematologic_malignancy

unknown

Hodgkin Lymphoma

Curated

Chronic Lymphocytic Leukemia

→ investigated for

Chronic Lymphocytic Leukemiahematologic_malignancy

unknown

Curated

Desmoplastic Small Round Cell Tumor

→ investigated for

Desmoplastic Small Round Cell Tumorsubtype

unknown

0.5

Curated

Irinotecan investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 287show all (up to 200)
→ investigated in trials for	Malignant Colorectal Neoplasmsubtype 273 trials (37 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	273	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Pancreatic Neoplasm 65 trials (23 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Pancreatic Neoplasm	65	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Gastric Neoplasm 63 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Gastric Neoplasm	63	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Neoplasmsubtype 44 trials (12 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Neoplasm	44	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Solid Neoplasm 43 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Solid Neoplasm	43	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Rectal Neoplasm 38 trials (7 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Rectal Neoplasm	38	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 38 trials (13 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	38	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Esophageal Neoplasm 37 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Esophageal Neoplasm	37	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 37 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	37	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Small Cell Carcinomasubtype 35 trials (7 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Small Cell Carcinoma	35	Observed	clinicaltrials	graph →
→ investigated in trials for	Pancreatic Adenocarcinomasubtype 34 trials (13 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Pancreatic Adenocarcinoma	34	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colon Neoplasm 33 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colon Neoplasm	33	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Lung Neoplasm 32 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Lung Neoplasm	32	Observed	clinicaltrials	graph →
→ investigated in trials for	Neuroblastomasubtype 31 trials (14 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Neuroblastoma	31	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Carcinoma 25 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Carcinoma	25	Observed	clinicaltrials	graph →

Irinotecan investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 287show all (up to 200)

→ investigated in trials for

273 trials (37 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

273

Observed

Malignant Pancreatic Neoplasm

→ investigated in trials for

65 trials (23 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Pancreatic Neoplasm

Observed

Malignant Gastric Neoplasm

→ investigated in trials for

63 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Gastric Neoplasm

Observed

→ investigated in trials for

Colorectal Neoplasmsubtype

44 trials (12 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Adult Solid Neoplasm

43 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Adult Solid Neoplasm

Observed

Malignant Rectal Neoplasm

→ investigated in trials for

38 trials (7 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Rectal Neoplasm

Observed

→ investigated in trials for

Solid Neoplasm

38 trials (13 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Solid Neoplasm

Observed

Malignant Esophageal Neoplasm

→ investigated in trials for

37 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Esophageal Neoplasm

Observed

→ investigated in trials for

Malignant Neoplasm

37 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Neoplasm

Observed

Lung Small Cell Carcinoma

→ investigated in trials for

Lung Small Cell Carcinomasubtype

35 trials (7 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

Pancreatic Adenocarcinoma

→ investigated in trials for

Pancreatic Adenocarcinomasubtype

34 trials (13 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Malignant Colon Neoplasm

33 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Colon Neoplasm

Observed

→ investigated in trials for

Malignant Lung Neoplasm

32 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Lung Neoplasm

Observed

→ investigated in trials for

Neuroblastomasubtype

31 trials (14 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Neuroblastoma

Observed

→ investigated in trials for

Colorectal Carcinoma

25 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Colorectal Carcinoma

Observed

Medulloblastoma,Childhood Medulloblastoma

Irinotecan studied in …STUDIED_INderived10 of 963show all (up to 200)
→ studied in	NCT07346157Phase 1/Phase 2 · recruiting Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease · 963 trials list this drug (181 active)	—	—	Medulloblastoma,Childhood Medulloblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07621718Phase 3 · recruiting Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 ) · 963 trials list this drug (181 active)	—	—	Malignant Pancreatic Neoplasm,Pancreatic Adenocarcinoma,Pancreatic Adenosquamous Carcinoma+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT02595931Phase 1 · active not recruiting M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery · 963 trials list this drug (181 active)	—	—	Malignant Solid Neoplasm,Malignant Lung Neoplasm,Malignant Pancreatic Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT05379595Phase 1/Phase 2 · recruiting A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer · 963 trials list this drug (181 active)	—	—	Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05610163Phase 2/Phase 3 · active not recruiting Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation and Continuing Response · 963 trials list this drug (181 active)	—	—	Malignant Rectal Neoplasm,Rectal Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06662786Phase 3 · recruiting A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer · 963 trials list this drug (181 active)	—	—	Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06750094Phase 3 · recruiting A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy · 963 trials list this drug (181 active)	—	—	Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07194044Phase 1 · recruiting Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes · 963 trials list this drug (181 active)	—	—	Ewing Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07271355Phase 3 · recruiting Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial · 963 trials list this drug (181 active)	—	—	Appendix Carcinoma,Colorectal Carcinoma,Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05863195Phase 3 · recruiting Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial · 963 trials list this drug (181 active)	—	—	Colorectal Neoplasm,Colorectal Carcinoma,Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →

Irinotecan studied in …STUDIED_INderived10 of 963show all (up to 200)

→ studied in

NCT07346157Phase 1/Phase 2 · recruiting

Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease · 963 trials list this drug (181 active)

—

Observed

Malignant Pancreatic Neoplasm,Pancreatic Adenocarcinoma,Pancreatic Adenosquamous Carcinoma+1

→ studied in

NCT07621718Phase 3 · recruiting

Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 ) · 963 trials list this drug (181 active)

—

Observed

Malignant Solid Neoplasm,Malignant Lung Neoplasm,Malignant Pancreatic Neoplasm+2

→ studied in

NCT02595931Phase 1 · active not recruiting

M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery · 963 trials list this drug (181 active)

—

Observed

→ studied in

NCT05379595Phase 1/Phase 2 · recruiting

A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer · 963 trials list this drug (181 active)

—

Observed

Malignant Rectal Neoplasm,Rectal Adenocarcinoma

→ studied in

NCT05610163Phase 2/Phase 3 · active not recruiting

Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation and Continuing Response · 963 trials list this drug (181 active)

—

Observed

→ studied in

NCT06662786Phase 3 · recruiting

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer · 963 trials list this drug (181 active)

—

Observed

→ studied in

NCT06750094Phase 3 · recruiting

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy · 963 trials list this drug (181 active)

—

Observed

→ studied in

NCT07194044Phase 1 · recruiting

Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes · 963 trials list this drug (181 active)

—

Ewing Sarcoma

Observed

Appendix Carcinoma,Colorectal Carcinoma,Malignant Colorectal Neoplasm

→ studied in

NCT07271355Phase 3 · recruiting

Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial · 963 trials list this drug (181 active)

—

Observed

Colorectal Neoplasm,Colorectal Carcinoma,Malignant Colorectal Neoplasm

→ studied in

NCT05863195Phase 3 · recruiting

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial · 963 trials list this drug (181 active)

—

Observed