NRAS G13R

CI-VAR-00001636Explore in graph →NP_002515.1:p.Gly13ArgNM_002524.4:c.37G>CClinVar 13899 CIViC 896 rs121434595

Curated evidence

Evidence by cancer (8 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–8 of 8 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acral Lentiginous Melanoma1
NRAS G13R	Belvarafenib	Predictive	C	Supports Sensitivity Response	2	accepted	EID13214 A patient with acral melanoma harboring NRAS G13R received belvarafenib monotherapy after four prior lines of systemic therapy and achieved stable disease as the best RECIST response. The patient rece… (full text at CIViC) PMID 38470950 · Kim et al., 2024 · Open in CIViC	civic
Malignant Colorectal Neoplasm5
NRAS G13R	Cetuximab + IrinotecanCombination	Predictive	C	Supports Resistance	1	accepted	EID2204 One patient participating in a large retrospective study of cetuximab in metastatic, treatment refractory colorectal cancer had a tumor which harbored NRAS G13R, was wildtype for KRAS, BRAF and PIK3CA…

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
13899	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Carcinoma of colon; Large congenital melanocytic nevus; Acute myeloid leukemia; Noonan syndrome 6; Linear nevus sebaceous syndrome; Rhabdomyosarcoma	germline/somatic	6	Jul 05, 2026	clinvar

Melanoma2
NRAS G13R	Vemurafenib	Predictive	C	Supports Resistance	—	submitted	EID3843 In a retrospective study of 30 metastatic melanoma patients, a patient harboring NRAS G13R mutation was reported to be resistant to vemurafenib treatment. The patient was initially found to harbor a B… (full text at CIViC) PMID 24463458 · Rizos et al., 2014 · Open in CIViC	civic
NRAS G13R	Vemurafenib	Predictive	C	Supports Resistance	—	submitted	EID3844 In a retrospective study of 44 malignant melanoma patients, NRAS G13R was associated with acquired resistance to vemurafenib monotherapy in one patient with disease progressive tumors harboring NRAS G… (full text at CIViC) PMID 24265155 · Shi et al., 2014 · Open in CIViC	civic