Aspirin

small molecule

Identifier: CI-DRUG-00000083
Entity page: /drug/aspirin ↗
Edges: 219

Neighbours: 22 cancers2 genes5 variants10 trials
Drawn: 39 of 39 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Aspirin predicts response to …PREDICTS_RESPONSE_TO5 of 5
← predicts response to	PIK3CA Mutationother 3 source records aggregated	sensitivity	B	Head and Neck Squamous Cell Carcinoma,Malignant Colorectal Neoplasm	3	Curated	civic	graph →
← predicts response to

Aspirin targets …TARGETS2 of 2
→ targets	PTGS1	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PTGS2	—	INHIBITOR	—	1	Curated	chembl	graph →

Aspirin targets …TARGETS2 of 2

→ targets

PTGS1

—

INHIBITOR

—

Curated

Aspirin investigated for …INVESTIGATED_FOR15 of 29show all (up to 200)
→ investigated for	Malignant Colorectal Neoplasmsubtype 3 source records aggregated	supports	B	Malignant Colorectal Neoplasm	3	Curated	civic	graph →
→ investigated for	Head and Neck Squamous Cell Carcinomasubtype	supports	B	Head and Neck Squamous Cell Carcinoma	1	Curated	civic	graph →
→ investigated for	Colorectal Neoplasmsubtype	unknown	3	Colorectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Colon Neoplasmsubtype	unknown	3	Colon Neoplasm	1	Curated	chembl	graph →
→ investigated for	Esophageal Neoplasmcancer_family	unknown	3	Esophageal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Gastric Neoplasmcancer_family	unknown	3	Gastric Neoplasm	1	Curated	chembl	graph →
→ investigated for	Multiple Myelomahematologic_malignancy	unknown	3	Multiple Myeloma	1	Curated	chembl	graph →
→ investigated for	Essential Thrombocythemiahematologic_malignancy	unknown	3	Essential Thrombocythemia	1	Curated	chembl	graph →
→ investigated for	Hepatocellular Carcinomasubtype	unknown	3	Hepatocellular Carcinoma	1	Curated	chembl	graph →
→ investigated for	Polycythemia Verahematologic_malignancy	unknown	3	Polycythemia Vera	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	3	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Breast Neoplasmcancer_family	unknown	3	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Squamous Cell Carcinomahistology	unknown	3	Squamous Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Nasopharyngeal Carcinomasubtype	unknown	2	Nasopharyngeal Carcinoma	1	Curated	chembl	graph →
→ investigated for	Oral Cavity Neoplasmsubtype	unknown	2	Oral Cavity Neoplasm	1	Curated	chembl	graph →

Aspirin investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 58show all (up to 200)
→ investigated in trials for	Malignant Colorectal Neoplasmsubtype 19 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	19	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 7 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Prostate Neoplasm 7 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Prostate Neoplasm	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Multiple Myelomahematologic_malignancy 7 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Multiple Myeloma	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Breast Neoplasm 6 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colon Neoplasm 6 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colon Neoplasm	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 6 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Polycythemia Verahematologic_malignancy 6 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Polycythemia Vera	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Breast Neoplasmcancer_family 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Neoplasmsubtype 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Esophageal Neoplasm 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Esophageal Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Ovarian Neoplasm 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Ovarian Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Adenoma 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Adenoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Essential Thrombocythemiahematologic_malignancy 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Essential Thrombocythemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Hepatocellular Carcinomasubtype 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hepatocellular Carcinoma	2	Observed	clinicaltrials	graph →

Aspirin studied in …STUDIED_INderived10 of 125show all (up to 200)
→ studied in	NCT03480776Phase 2 · active not recruiting ASA in Prevention of Ovarian Cancer (STICs and STONEs) · 125 trials list this drug (29 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT05080946early Phase 1 · suspended Using Aspirin to Improve Immunological Features of Ovarian Tumors · 125 trials list this drug (29 active)	—	—	Malignant Peritoneal Neoplasm,Malignant Fallopian Tube Neoplasm,Malignant Ovarian Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02521285Phase 2 · active not recruiting Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation · 125 trials list this drug (29 active)	—	—	Esophageal Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02927249Phase 3 · terminated Aspirin in Preventing Recurrence of Cancer in Patients With HER2 Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy · 125 trials list this drug (29 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT05557877Phase 2 · recruiting Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer · 125 trials list this drug (29 active)	—	—	Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02965703Phase 2 · active not recruiting Aspirin in Preventing Colorectal Cancer in Patients With Colorectal Adenoma · 125 trials list this drug (29 active)	—	—	Colorectal Adenoma,Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07281547Phase 4 · not yet recruiting Low Dose Aspirin to Lower Inflammation and Prevent Endometrial Cancer in Postmenopausal Women With Non-atrophic Endometrial Changes and Pain · 125 trials list this drug (29 active)	—	—	Endometrial Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06866964Phase 2 · recruiting A Single-arm, Phase II Clinical Trial of ASPIRin to prEvent Venous Thromboembolism in Patients With Advanced Germ Cell Tumors Receiving Chemotherapy · 125 trials list this drug (29 active)	—	—	Germ Cell Tumor,Malignant Testicular Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT03805932Phase 1 · active not recruiting Moxetumomab Pasudotox-tdfk (Lumoxiti(TM)) and Either Rituximab (Rituxan(R)) or Ruxience for Relapsed Hairy Cell Leukemia · 125 trials list this drug (29 active)	—	—	Hairy Cell Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT05056896early Phase 1 · active not recruiting ASPIRED-XT: ASPirin Intervention for the REDuction of Colorectal Cancer Risk -EXTension · 125 trials list this drug (29 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →

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