Variant
PIK3CA Exon 21 Mutation
CI-VAR-00001012Explore in graph →CIViC 105
Curated evidence
Evidence by cancer (6 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 17947469
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Malignant Breast Neoplasm1 | ||||||||
| PIK3CA Exon 21 Mutation | (prognostic) | Prognostic | B | Supports Better Outcome | 4 | accepted | EID6198An Italian study of 163 malignant breast tumors assessed the association between PIK3CA mutations and clinical outcome. Of the 163 tumors sequenced, 118 had wild-type (wt) PIK3CA, 24 had exon 9 (helic… (full text at CIViC) PMID 17947469 · Barbareschi et al., 2007 · Open in CIViC | civic |
| Malignant Colorectal Neoplasm4 | ||||||||
| PIK3CA Exon 21 Mutation | (prognostic) | Prognostic | B | Does Not Support Poor Outcome | 2 | accepted | EID3729This study analyzed tumor and patient characteristics from 1,170 colorectal cancer patients derived from the prospective cohort studies: Nurses' Health Study and Health Professionals Follow Up Study. … (full text at CIViC) PMID 22357840 · | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available