Variant

PIK3CA Exon 10 Mutation

CI-VAR-00000987Explore in graph →p.Glu542LysNM_006218.4:c.1624G>AClinVar 31944 CIViC 106 rs121913273

Curated evidence

Evidence by cancer (6 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–6 of 6 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Breast Neoplasm1
PIK3CA Exon 10 Mutation	(prognostic)	Prognostic	B	Supports Poor Outcome	4	accepted	EID6199 An Italian study of 163 malignant breast tumors assessed the association between PIK3CA mutations and clinical outcome. Of the 163 tumors sequenced, 118 had wild-type (wt) PIK3CA, 24 had exon 9 (helic… (full text at CIViC) PMID 17947469 · Barbareschi et al., 2007 · Open in CIViC	civic
Malignant Colorectal Neoplasm4
PIK3CA Exon 10 Mutation	(prognostic)	Prognostic	B	Does Not Support Poor Outcome	2	accepted	EID384 This study analyzed tumor and patient characteristics from 1,170 colorectal cancer patients derived from the prospective cohort studies: Nurses' Health Study and Health Professionals Follow Up Study. … (full text at CIViC) PMID 22357840 ·

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
31944	Pathogenic	reviewed by expert panel	3	CLOVES syndrome; Ovarian neoplasm; Non-small cell lung carcinoma; CLAPO syndrome; Lip and oral cavity carcinoma; Abnormal cardiovascular system morphology; CEREBRAL CAVERNOUS MALFORMATIONS 4, SOMATIC; Cerebrofacial Vascular Metameric Syndrome (CVMS); Overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes; Cowden syndrome; PIK3CA-related overgrowth; PIK3CA-related disorder; PIK3CA related overgrowth syndrome; HEMIFACIAL MYOHYPERPLASIA, SOMATIC; Rare venous malformation; Megalencephaly-capillary malformation-polymicrogyria syndrome; Neoplasm; Alveolar rhabdomyosarcoma; Diffuse midline glioma, H3 K27M-mutant; Rosette-forming glioneuronal tumor; Vascular malformation; Glioma; Cervical squamous cell carcinoma