PTGS2

prostaglandin-endoperoxide synthase 2

Explore in graph →CI-GENE-00022450HGNC:9605 ENSG00000073756 NCBI 5743 CIViC Approved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PTGS2 Overexpression1
Aspirin	Malignant Colorectal NeoplasmCURATED_BROADER	Predictive	B	Supports Sensitivity Response	3	submitted	EID1573 Mail-in surveys conducted every two years since 1980 evaluated 82,911 woman and 47,363 men for regular aspirin use. In this cohort, aspirin use was associated with a lower relative risk of colorectal… (full text at CIViC) PMID 17522398 · Chan et al., 2007 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Pilocytic Astrocytoma (ICGC, Nature Genetics 2013) past_dkfz_heidelberg_2013	Pilocytic Astrocytoma	Ssm	1	96

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.