Drug · Small Molecule

Aspirin

CI-DRUG-00000083Explore in graph →NCIt C287 CHEMBL25 CIViC Approved

Regulatory

Approvals (0)

Each record names the authority, jurisdiction, indication text and status. A drug approved in one jurisdiction for one indication is not 'approved' in general.

Data not yet available

No regulatory approval recorded. Absence here is not evidence of absence: only ingested jurisdictions are covered.

What CancerIndex knows

Curated evidence below
Sources

Derived

Development pipeline

Most advanced stage across all cancers, then per top-level cancer reached through trial conditions or approval indications. Approval in any ingested jurisdiction outranks trial phase; counts are interventional studies.

Scope	Stage	Max phase	Active	Recruiting	Phase 3	Trials	Jurisdictions	First approval	First trial
All cancers	Phase4	Phase 4	29	8	37	119	—	—	1992-02
Malignant Prostate Neoplasm	Phase4	Phase 4	2	1	4	7	—	—	Nov 14, 2002
Malignant Uterine Corpus Neoplasm	Phase4	Phase 4	1	0	0	2	—	—	Jul 1, 2017
Malignant Ovarian Neoplasm	Phase4	Phase 4	0	0	0	3

Curated evidence

Clinical evidence (19)

CIViC items in which this therapy appears, grouped by cancer context, then molecular profile. 50 items per page.

civicCuratedShowing 1–19 of 19 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PIK3CA Amplification1
Aspirin + Ibuprofen

Clinical trials

Trials with this intervention (125)

Most recently updated first, 50 per page.

clinicaltrialsPublishedShowing 1–50 of 125 studies · status and phase as posted by the registrant; each row links to the study record.

NCT	Title	Status	Phase	Enrollment (n)	Sponsor	Countries	Last update	Source
NCT03480776	ASA in Prevention of Ovarian Cancer (STICs and STONEs)	active not recruiting	Phase 2	117	Canadian Cancer Trials GroupNETWORK	2	Sep 16, 2026	clinicaltrials
NCT05080946	Using Aspirin to Improve Immunological Features of Ovarian Tumors	suspended	Early Phase 1	100

Molecule

Record

Kind: Small Molecule
Mechanism: Cyclooxygenase inhibitor
Targets: 2 genes
Aliases: 2-(Acetyloxy)benzoic Acid, 8-hour bayer, Acetosalic acid, Acetylsalic acid, Acetyl salicylate, Acetylsalicylic Acid, Acetylsalicylic acid (who-ip), Acetylsalicylicum acidum, Acidum acetylsalicylicum, Acidum acetylsalicylicum (who-ip), Alka rapid, Anadin all night, Angettes 75, ASA, Aspergum, Aspirin, Aspirin component of aggrenox, Aspirin component of axotal, Aspirin component of azdone, Aspirin component of carisoprodol compound, Aspirin component of clopidogrel/acetylsalicylic acid, Aspirin component of codoxy, Aspirin component of darvon compound, Aspirin component of duocover, Aspirin component of duoplavin, Aspirin component of equagesic, Aspirin component of excedrin, Aspirin component of fiorinal, Aspirin component of invagesic, Aspirin component of invagesic forte … (+52)

Data updated 21 hours agoSource updated unknown

Identifiers

Codes (0)

Upstream identifiers kept as first-class codes; each links to its registry where a stable public URL exists.

Data not yet available

No cross-reference code recorded yet beyond the record identifiers above.

Regulatory status is jurisdiction-specific and time-bound. Nothing on this page is a treatment recommendation.

PIK3CA Mutation3
Aspirin + Celecoxib + SulindacSubstitutes	Head and Neck Squamous Cell Carcinoma	Predictive	B	Supports Sensitivity Response	3	accepted	EID7185 In this retrospective study, the impact of nonsteroidal anti-inflammatory drugs (NSAID) on survival in PIK3CA-altered HNSCC patients (N=266) was assessed. 37 of 266 (14%) patients harbored a mutation,… (full text at CIViC) PMID 30683736 · Hedberg et al., 2019 · Open in CIViC	civic
Aspirin	Malignant Colorectal NeoplasmCURATED_BROADER	Predictive	B	Supports Sensitivity Response	3	accepted	EID6375 This was a retrospective study of 964 colorectal cancer patients who participated in the Nurses' Health Study and the Health Professionals Follow-up Study. Of 964 patients, 803 patients had wildtype P… (full text at CIViC) PMID 23094721 · Liao et al., 2012 · Open in CIViC	civic
〃	Malignant Colorectal NeoplasmCURATED_BROADER	Predictive	B	Supports Sensitivity Response	3	rejected	EID7187 In this retrospective study in 964 patients with colorectal cancer (CRC), the regular use of aspirin after diagnosis was significantly associated with cancer-specific (HR 0.18, p<0.001) and overall su… (full text at CIViC) PMID 23094721 · Liao et al., 2012 · Open in CIViC	civic

PIK3CA Mutation3

Aspirin + Celecoxib + SulindacSubstitutes

Head and Neck Squamous Cell Carcinoma

Predictive

Supports Sensitivity Response

accepted

EID7185

In this retrospective study, the impact of nonsteroidal anti-inflammatory drugs (NSAID) on survival in PIK3CA-altered HNSCC patients (N=266) was assessed. 37 of 266 (14%) patients harbored a mutation,… (full text at CIViC)

PMID 30683736 · Hedberg et al., 2019 · Open in CIViC