PIK3R1 Mutation

CI-VAR-00002683Explore in graph →CIViC 633

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 4 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Glioblastoma1
PIK3R1 Mutation	Buparlisib	Predictive	B	Does Not Support Sensitivity Response	3	submitted	EID7073 In this multicenter, open-label, multi-arm, phase 2 trial, 65 patients with PI3K pathway aberrations (defined by PTEN and pAKT IHC-Status in 95%, genomic testing in 5%) were treated with the PI3K inhi… (full text at CIViC) PMID 30715997 · Wen et al., 2019 · Open in CIViC	civic
Malignant Breast Neoplasm1
PIK3R1 Mutation	MTOR Kinase Inhibitor PP242	Predictive	D	Supports Sensitivity Response	2	accepted	EID1612 Sensitivity to mTORC1/2 inhibitor PP242 was assessed in a panel of breast cancer cell lines with various mutation backgrounds. PTEN and PIK3CA mutations were heavily represented in the panel. However,… (full text at CIViC)

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Malignant Colorectal Neoplasm1
PIK3CA Mutation OR PTEN Mutation OR PIK3R1 Mutation	Aspirin	Predictive	B	Supports Sensitivity Response	4	accepted	EID12602 In a randomized, double blind, placebo controlled adjuvant trial in colorectal carcinoma with PI3K pathway mutations (ALASCCA, NCT02647099; group B n = 312), aspirin 160 mg daily (group B n = 156) for… (full text at CIViC) PMID 40961426 · Martling et al., 2025 · Open in CIViC	civic

Sarcoma1
ATM Mutation OR TP53 Mutation OR PIK3R1 Mutation OR PIK3CB Mutation OR NTRK1 Mutation OR CSF2RB Mutation	Doxorubicin	Predictive	D	Supports Sensitivity Response	3	submitted	EID12721 In primary soft tissue sarcoma cultures (UPS n = 25, SS n = 12), tumors with at least one mutation in apoptosis pathway genes (TP53, ATM, PIK3CB, PIK3R1, NTRK1 or CSF2RB; Mut+ n = 10, Mut− n = 27) wer… (full text at CIViC) PMID 35406568 · Kirilin et al., 2022 · Open in CIViC	civic