Hepatocellular Carcinoma — Genomics

Hepatocellular Carcinoma — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

13 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Hepatocellular Carcinoma (CLCA, Nature 2024) hcc_clca_2024CLCA

494 cases with simple somatic mutation data · 494 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Hepatocellular Carcinoma (MERiC/Basel, Nat Commun. 2022) hcc_meric_2021MERiC/Basel

122 cases with simple somatic mutation data · 122 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	CTNNB1	Ssm	45	122	36.9%	cbioportal
2	TP53	Ssm	41	122	33.6%	cbioportal
3	TTN	Ssm	29	122	23.8%	cbioportal
5	PCLO	Ssm	24	122	19.7%	cbioportal
4	ARID1A	Ssm	24	122	19.7%	cbioportal
6	OBSCN	Ssm	19	122	15.6%	cbioportal
7	MUC16	Ssm	18	122	14.8%	cbioportal
8	ALB	Ssm	17	122	13.9%	cbioportal
9	FLG	Ssm	17	122	13.9%	cbioportal
11	CSMD3	Ssm	15	122	12.3%	cbioportal
10	APOB	Ssm	15	122	12.3%	cbioportal
13	SYNE1	Ssm	13	122	10.7%	cbioportal
12	MUC4	Ssm	13	122	10.7%	cbioportal
15	XIRP2	Ssm	12	122	9.8%	cbioportal
14	ADGRV1	Ssm	12	122	9.8%	cbioportal
16	ABCA13	Ssm	11	122	9%	cbioportal
18	LRP1B	Ssm	11	122	9%	cbioportal
17	HYDIN	Ssm	11	122	9%	cbioportal
20	FBN1	Ssm	10	122	8.2%	cbioportal
21	HMCN1	Ssm	10	122	8.2%	cbioportal
19	COL22A1	Ssm	10	122	8.2%	cbioportal
22	ANK3	Ssm	9	122	7.4%	cbioportal
35	WDFY4	Ssm	9	122	7.4%	cbioportal
29	FAT3	Ssm	9	122	7.4%	cbioportal
25	CSMD2	Ssm	9	122	7.4%	cbioportal
31	GRM5	Ssm	9	122	7.4%	cbioportal
24	CDKN1A	Ssm	9	122	7.4%	cbioportal
23	APC	Ssm	9	122	7.4%	cbioportal
33	MUC17	Ssm	9	122	7.4%	cbioportal
32	LAMA1	Ssm	9	122	7.4%	cbioportal

Data updated 23 days agoSource updated 2026-01-07

Hepatocellular Carcinoma (MSK, Clin Cancer Res 2018) hcc_mskimpact_2018MSK

127 cases with simple somatic mutation data · 127 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	68	127	53.5%	cbioportal
2	CTNNB1	Ssm	44	127	34.6%	cbioportal
3	TP53	Ssm	39	127	30.7%	cbioportal
4	ARID1A	Ssm	17	127	13.4%	cbioportal
5	TSC2	Ssm	11	127	8.7%	cbioportal
50	PREX2	Ssm	3	36	8.3%	cbioportal
6	NFE2L2	Ssm	8	127	6.3%	cbioportal
7	APC	Ssm	7	127	5.5%	cbioportal
11	SF3B1	Ssm	7	127	5.5%	cbioportal
10	KMT2D	Ssm	7	127	5.5%	cbioportal
9	JAK1	Ssm	7	127	5.5%	cbioportal
8	AXIN1	Ssm	7	127	5.5%	cbioportal
12	ARID2	Ssm	6	127	4.7%	cbioportal
13	BAP1	Ssm	6	127	4.7%	cbioportal
23	ZRSR2	Ssm	5	106	4.7%	cbioportal
21	RB1	Ssm	5	127	3.9%	cbioportal
20	PTPRT	Ssm	5	127	3.9%	cbioportal
14	ALK	Ssm	5	127	3.9%	cbioportal
19	NOTCH1	Ssm	5	127	3.9%	cbioportal
18	KMT2A	Ssm	5	127	3.9%	cbioportal
15	CDKN1A	Ssm	5	127	3.9%	cbioportal
16	IGF1R	Ssm	5	127	3.9%	cbioportal
22	SETD2	Ssm	5	127	3.9%	cbioportal
17	KDR	Ssm	5	127	3.9%	cbioportal
35	ZFHX3	Ssm	4	106	3.8%	cbioportal
33	PTPRS	Ssm	4	127	3.1%	cbioportal
32	PTPRD	Ssm	4	127	3.1%	cbioportal
31	PBRM1	Ssm	4	127	3.1%	cbioportal
25	CREBBP	Ssm	4	127	3.1%	cbioportal
34	SMARCA4	Ssm	4	127	3.1%	cbioportal

Data updated 23 days agoSource updated 2026-01-07

Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024) hcc_msk_2024MSK

1,370 cases with simple somatic mutation data · 1,370 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	466	1,370	34%	cbioportal
2	ARID1A	Ssm	226	1,370	16.5%	cbioportal
3	TERT	Ssm	225	1,370	16.4%	cbioportal
4	KRAS	Ssm	152	1,370	11.1%	cbioportal
5	IDH1	Ssm	141	1,370	10.3%	cbioportal
6	CTNNB1	Ssm	132	1,370	9.6%	cbioportal
7	BAP1	Ssm	117	1,370	8.5%	cbioportal
85	ALB	Ssm	18	221	8.1%	cbioportal
8	SMAD4	Ssm	103	1,370	7.5%	cbioportal
9	PBRM1	Ssm	95	1,370	6.9%	cbioportal
10	ATM	Ssm	74	1,370	5.4%	cbioportal
11	KMT2C	Ssm	69	1,370	5%	cbioportal
12	ARID2	Ssm	67	1,370	4.9%	cbioportal
13	PIK3CA	Ssm	67	1,370	4.9%	cbioportal
18	ELF3	Ssm	47	998	4.7%	cbioportal
14	KMT2D	Ssm	64	1,370	4.7%	cbioportal
15	CDKN2A	Ssm	62	1,370	4.5%	cbioportal
16	BRAF	Ssm	52	1,370	3.8%	cbioportal
32	PREX2	Ssm	35	998	3.5%	cbioportal
17	NF1	Ssm	48	1,370	3.5%	cbioportal
19	ERBB3	Ssm	44	1,370	3.2%	cbioportal
20	RB1	Ssm	44	1,370	3.2%	cbioportal
21	KMT2A	Ssm	42	1,370	3.1%	cbioportal
23	FGFR2	Ssm	41	1,370	3%	cbioportal
24	STK11	Ssm	41	1,370	3%	cbioportal
22	APC	Ssm	41	1,370	3%	cbioportal
41	KMT2B	Ssm	29	998	2.9%	cbioportal
28	ZFHX3	Ssm	37	1,284	2.9%	cbioportal
25	AXIN1	Ssm	39	1,370	2.8%	cbioportal
27	RASA1	Ssm	37	1,370	2.7%	cbioportal

Data updated 23 days agoSource updated 2026-01-07

Hepatocellular Carcinoma (MSK, JCO Precis Oncol 2023) hcc_jcopo_msk_2023MSK

90 cases with simple somatic mutation data · 90 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	54	90	60%	cbioportal
2	TP53	Ssm	45	90	50%	cbioportal
3	CTNNB1	Ssm	35	90	38.9%	cbioportal
4	TSC2	Ssm	26	90	28.9%	cbioportal
28	ALB	Ssm	2	7	28.6%	cbioportal
5	ARID1A	Ssm	20	90	22.2%	cbioportal
103	SETDB1	Ssm	1	7	14.3%	cbioportal
9	AXIN1	Ssm	5	37	13.5%	cbioportal
15	CDKN1A	Ssm	4	37	10.8%	cbioportal
6	PIK3CA	Ssm	9	90	10%	cbioportal
7	APC	Ssm	8	90	8.9%	cbioportal
25	PTPRD	Ssm	3	37	8.1%	cbioportal
23	KMT2D	Ssm	3	37	8.1%	cbioportal
8	NF1	Ssm	7	90	7.8%	cbioportal
42	KMT2B	Ssm	2	27	7.4%	cbioportal
34	EPHA7	Ssm	2	35	5.7%	cbioportal
55	ZRSR2	Ssm	2	35	5.7%	cbioportal
39	H3-4	Ssm	2	35	5.7%	cbioportal
48	PPM1D	Ssm	2	35	5.7%	cbioportal
54	ZFHX3	Ssm	2	35	5.7%	cbioportal
11	NFE2L2	Ssm	5	90	5.6%	cbioportal
12	PAK5	Ssm	5	90	5.6%	cbioportal
10	KDM6A	Ssm	5	90	5.6%	cbioportal
32	CDK12	Ssm	2	37	5.4%	cbioportal
40	INPP4B	Ssm	2	37	5.4%	cbioportal
31	BAP1	Ssm	2	37	5.4%	cbioportal
14	BRCA1	Ssm	4	90	4.4%	cbioportal
18	RB1	Ssm	4	90	4.4%	cbioportal
19	TSC1	Ssm	4	90	4.4%	cbioportal
16	DNMT3A	Ssm	4	90	4.4%	cbioportal

Data updated 23 days agoSource updated 2026-01-07

Hepatocellular Carcinomas (INSERM, Nat Genet 2015) hcc_inserm_fr_2015INSERM

243 cases with simple somatic mutation data · 243 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	139	243	57.2%	cbioportal
2	CTNNB1	Ssm	88	243	36.2%	cbioportal
3	TP53	Ssm	54	243	22.2%	cbioportal
4	TTN	Ssm	52	243	21.4%	cbioportal
5	MUC16	Ssm	28	243	11.5%	cbioportal
6	ALB	Ssm	27	243	11.1%	cbioportal
7	ARID1A	Ssm	24	243	9.9%	cbioportal
8	APOB	Ssm	22	243	9.1%	cbioportal
9	AXIN1	Ssm	21	243	8.6%	cbioportal
10	PCLO	Ssm	21	243	8.6%	cbioportal
11	CSMD1	Ssm	20	243	8.2%	cbioportal
12	RYR2	Ssm	20	243	8.2%	cbioportal
13	OBSCN	Ssm	19	243	7.8%	cbioportal
14	COL11A1	Ssm	18	243	7.4%	cbioportal
15	DNAH7	Ssm	16	243	6.6%	cbioportal
20	RPS6KA3	Ssm	15	243	6.2%	cbioportal
18	FBN2	Ssm	15	243	6.2%	cbioportal
19	PCDH15	Ssm	15	243	6.2%	cbioportal
17	CSMD3	Ssm	15	243	6.2%	cbioportal
16	ARID2	Ssm	15	243	6.2%	cbioportal
23	LRP1B	Ssm	14	243	5.8%	cbioportal
21	DNAH9	Ssm	14	243	5.8%	cbioportal
22	KMT2D	Ssm	14	243	5.8%	cbioportal
25	RYR1	Ssm	14	243	5.8%	cbioportal
26	SPTA1	Ssm	14	243	5.8%	cbioportal
27	USH2A	Ssm	14	243	5.8%	cbioportal
24	NFE2L2	Ssm	14	243	5.8%	cbioportal
28	FRAS1	Ssm	13	243	5.3%	cbioportal
34	XIRP2	Ssm	12	243	4.9%	cbioportal
29	ATM	Ssm	12	243	4.9%	cbioportal

Data updated 23 days agoSource updated 2026-01-07

Hepatocellular Carcinoma (TCGA GDC, 2025) hcc_tcga_gdcTCGA GDC

370 cases with simple somatic mutation data · 379 cases total · 2026-01-13 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	107	370	28.9%	cbioportal
2	CTNNB1	Ssm	95	370	25.7%	cbioportal
3	TTN	Ssm	90	370	24.3%	cbioportal
4	MUC16	Ssm	59	370	15.9%	cbioportal
5	ALB	Ssm	48	370	13%	cbioportal
6	PCLO	Ssm	42	370	11.4%	cbioportal
7	RYR2	Ssm	34	370	9.2%	cbioportal
8	LRP1B	Ssm	32	370	8.6%	cbioportal
9	APOB	Ssm	31	370	8.4%	cbioportal
10	CSMD3	Ssm	29	370	7.8%	cbioportal
11	XIRP2	Ssm	29	370	7.8%	cbioportal
12	ARID1A	Ssm	28	370	7.6%	cbioportal
13	OBSCN	Ssm	28	370	7.6%	cbioportal
14	ABCA13	Ssm	27	370	7.3%	cbioportal
15	FLG	Ssm	27	370	7.3%	cbioportal
17	HMCN1	Ssm	26	370	7%	cbioportal
16	AXIN1	Ssm	26	370	7%	cbioportal
18	CACNA1E	Ssm	25	370	6.8%	cbioportal
20	SPTA1	Ssm	24	370	6.5%	cbioportal
21	USH2A	Ssm	24	370	6.5%	cbioportal
19	CUBN	Ssm	24	370	6.5%	cbioportal
24	DOCK2	Ssm	23	370	6.2%	cbioportal
22	ADGRV1	Ssm	23	370	6.2%	cbioportal
23	DNAH7	Ssm	23	370	6.2%	cbioportal
25	RYR1	Ssm	22	370	5.9%	cbioportal
28	DMD	Ssm	21	370	5.7%	cbioportal
29	FAT3	Ssm	21	370	5.7%	cbioportal
30	PRKDC	Ssm	21	370	5.7%	cbioportal
26	COL11A1	Ssm	21	370	5.7%	cbioportal
27	CSMD1	Ssm	21	370	5.7%	cbioportal

Data updated 23 days agoSource updated 2026-01-13

Liver Hepatocellular Adenoma and Carcinomas (MSK, PLOS One 2018) hcc_msk_venturaa_2018MSK

19 cases with simple somatic mutation data · 19 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	7	19	36.8%	cbioportal
3	HNF1A	Ssm	3	19	15.8%	cbioportal
2	CTNNB1	Ssm	3	19	15.8%	cbioportal
4	TP53	Ssm	3	19	15.8%	cbioportal
5	APC	Ssm	2	19	10.5%	cbioportal
6	PIK3CA	Ssm	2	19	10.5%	cbioportal
22	ERG	Ssm	1	19	5.3%	cbioportal
21	EP300	Ssm	1	19	5.3%	cbioportal
20	EED	Ssm	1	19	5.3%	cbioportal
19	DNMT3B	Ssm	1	19	5.3%	cbioportal
18	CUL3	Ssm	1	19	5.3%	cbioportal
17	CTCF	Ssm	1	19	5.3%	cbioportal
26	KDM6A	Ssm	1	19	5.3%	cbioportal
30	LATS1	Ssm	1	19	5.3%	cbioportal
31	MSH6	Ssm	1	19	5.3%	cbioportal
32	NOTCH3	Ssm	1	19	5.3%	cbioportal
33	NSD1	Ssm	1	19	5.3%	cbioportal
34	PAK5	Ssm	1	19	5.3%	cbioportal
35	PAX5	Ssm	1	19	5.3%	cbioportal
41	SETD2	Ssm	1	19	5.3%	cbioportal
39	RB1	Ssm	1	19	5.3%	cbioportal
38	PTPRT	Ssm	1	19	5.3%	cbioportal
37	PIK3CG	Ssm	1	19	5.3%	cbioportal
36	PHOX2B	Ssm	1	19	5.3%	cbioportal
28	KMT2C	Ssm	1	19	5.3%	cbioportal
27	KEAP1	Ssm	1	19	5.3%	cbioportal
29	KMT2D	Ssm	1	19	5.3%	cbioportal
25	HGF	Ssm	1	19	5.3%	cbioportal
24	GNAS	Ssm	1	19	5.3%	cbioportal
23	FAT1	Ssm	1	19	5.3%	cbioportal

Data updated 23 days agoSource updated 2026-01-07

Liver Hepatocellular Carcinoma TCGA-LIHCTCGA

377 cases with simple somatic mutation data · 377 cases total · Data Release 46.0 · mapped to Hepatocellular Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ASH1L	Ssm	279	377	74%	gdc
2	RUSC1	Ssm	277	377	73.5%	gdc
4	THBS3	Ssm	276	377	73.2%	gdc
7	FAM189B	Ssm	276	377	73.2%	gdc
6	PKLR	Ssm	276	377	73.2%	gdc
3	EFNA3	Ssm	276	377	73.2%	gdc
5	SLC50A1	Ssm	276	377	73.2%	gdc
9	SCAMP3	Ssm	275	377	72.9%	gdc
8	AL691442.1	Ssm	275	377	72.9%	gdc
17	MTX1	Ssm	275	377	72.9%	gdc
18	FDPS	Ssm	275	377	72.9%	gdc
16	ZBTB7B	Ssm	275	377	72.9%	gdc
15	EFNA1	Ssm	275	377	72.9%	gdc
14	DCST2	Ssm	275	377	72.9%	gdc
13	INSRR	Ssm	275	377	72.9%	gdc
12	ADAM15	Ssm	275	377	72.9%	gdc
11	TRIM46	Ssm	275	377	72.9%	gdc
10	CLK2	Ssm	275	377	72.9%	gdc
21	AL713999.2	Ssm	274	377	72.7%	gdc
28	KRTCAP2	Ssm	274	377	72.7%	gdc
27	DPM3	Ssm	274	377	72.7%	gdc
30	YY1AP1	Ssm	274	377	72.7%	gdc
26	HCN3	Ssm	274	377	72.7%	gdc
19	EFNA4	Ssm	274	377	72.7%	gdc
20	KHDC4	Ssm	274	377	72.7%	gdc
22	MUC1	Ssm	274	377	72.7%	gdc
29	ARHGEF2	Ssm	274	377	72.7%	gdc
23	DCST1	Ssm	274	377	72.7%	gdc
25	GBA	Ssm	274	377	72.7%	gdc
24	LENEP	Ssm	274	377	72.7%	gdc

Data updated 46 minutes agoSource updated Data Release 46.0

Liver Hepatocellular Carcinoma (AMC, Hepatology 2014) lihc_amc_prvAMC

231 cases with simple somatic mutation data · 231 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	71	231	30.7%	cbioportal
2	CTNNB1	Ssm	52	231	22.5%	cbioportal
3	TTN	Ssm	52	231	22.5%	cbioportal
4	MUC16	Ssm	40	231	17.3%	cbioportal
5	HMCN1	Ssm	26	231	11.3%	cbioportal
6	PCLO	Ssm	26	231	11.3%	cbioportal
7	ADGRV1	Ssm	25	231	10.8%	cbioportal
8	HYDIN	Ssm	21	231	9.1%	cbioportal
10	SYNE1	Ssm	19	231	8.2%	cbioportal
9	LRP1B	Ssm	19	231	8.2%	cbioportal
16	VCAN	Ssm	18	231	7.8%	cbioportal
11	APOB	Ssm	18	231	7.8%	cbioportal
12	DNAH5	Ssm	18	231	7.8%	cbioportal
13	MUC4	Ssm	18	231	7.8%	cbioportal
14	RYR2	Ssm	18	231	7.8%	cbioportal
15	RYR3	Ssm	18	231	7.8%	cbioportal
17	FBN2	Ssm	17	231	7.4%	cbioportal
18	PKHD1L1	Ssm	16	231	6.9%	cbioportal
19	ABCA13	Ssm	15	231	6.5%	cbioportal
23	XIRP2	Ssm	15	231	6.5%	cbioportal
22	LIAT1	Ssm	15	231	6.5%	cbioportal
21	FLG	Ssm	15	231	6.5%	cbioportal
20	CSMD3	Ssm	15	231	6.5%	cbioportal
27	OBSCN	Ssm	14	231	6.1%	cbioportal
26	MDN1	Ssm	14	231	6.1%	cbioportal
25	BLTP1	Ssm	14	231	6.1%	cbioportal
24	AXIN1	Ssm	14	231	6.1%	cbioportal
28	AHNAK2	Ssm	13	231	5.6%	cbioportal
34	PXDN	Ssm	13	231	5.6%	cbioportal
33	PRUNE2	Ssm	13	231	5.6%	cbioportal

Data updated 23 days agoSource updated 2026-01-07

Liver Hepatocellular Carcinoma (RIKEN, Nat Genet 2012) lihc_rikenRIKEN

27 cases with simple somatic mutation data · 27 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved14 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	13	27	48.1%	cbioportal
2	ATM	Ssm	4	27	14.8%	cbioportal
3	ARID1A	Ssm	3	27	11.1%	cbioportal
6	WWP1	Ssm	3	27	11.1%	cbioportal
5	CTNNB1	Ssm	3	27	11.1%	cbioportal
4	BAZ2B	Ssm	3	27	11.1%	cbioportal
13	ZIC3	Ssm	2	27	7.4%	cbioportal
7	ALB	Ssm	2	27	7.4%	cbioportal
8	ERRFI1	Ssm	2	27	7.4%	cbioportal
9	GXYLT1	Ssm	2	27	7.4%	cbioportal
10	IGSF10	Ssm	2	27	7.4%	cbioportal
11	OTOP1	Ssm	2	27	7.4%	cbioportal
12	USP25	Ssm	2	27	7.4%	cbioportal
14	UBR3	Ssm	1	27	3.7%	cbioportal

Data updated 23 days agoSource updated 2026-01-07

Liver Hepatocellular Carcinoma (TCGA, Firehose Legacy) lihc_tcgaTCGA

373 cases with simple somatic mutation data · 379 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	115	373	30.8%	cbioportal
2	TTN	Ssm	105	373	28.2%	cbioportal
3	CTNNB1	Ssm	97	373	26%	cbioportal
4	MUC16	Ssm	54	373	14.5%	cbioportal
5	ALB	Ssm	43	373	11.5%	cbioportal
7	RYR2	Ssm	39	373	10.5%	cbioportal
6	APOB	Ssm	39	373	10.5%	cbioportal
8	PCLO	Ssm	35	373	9.4%	cbioportal
10	LRP1B	Ssm	33	373	8.8%	cbioportal
9	CSMD3	Ssm	33	373	8.8%	cbioportal
11	OBSCN	Ssm	33	373	8.8%	cbioportal
12	ABCA13	Ssm	32	373	8.6%	cbioportal
13	ARID1A	Ssm	32	373	8.6%	cbioportal
14	CACNA1E	Ssm	31	373	8.3%	cbioportal
15	RYR1	Ssm	30	373	8%	cbioportal
16	XIRP2	Ssm	29	373	7.8%	cbioportal
17	SPTA1	Ssm	28	373	7.5%	cbioportal
18	HMCN1	Ssm	27	373	7.2%	cbioportal
21	FRAS1	Ssm	26	373	7%	cbioportal
19	AHNAK2	Ssm	26	373	7%	cbioportal
20	FLG	Ssm	26	373	7%	cbioportal
22	USH2A	Ssm	26	373	7%	cbioportal
23	FAT3	Ssm	25	373	6.7%	cbioportal
24	MUC4	Ssm	25	373	6.7%	cbioportal
27	AXIN1	Ssm	24	373	6.4%	cbioportal
25	ADGRV1	Ssm	24	373	6.4%	cbioportal
26	ALMS1	Ssm	24	373	6.4%	cbioportal
28	DNAH6	Ssm	24	373	6.4%	cbioportal
30	DNAH7	Ssm	23	373	6.2%	cbioportal
29	CSMD1	Ssm	23	373	6.2%	cbioportal

Data updated 23 days agoSource updated 2026-01-07

Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) lihc_tcga_pan_can_atlas_2018TCGA

366 cases with simple somatic mutation data · 372 cases total · 2026-06-03 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	110	366	30.1%	cbioportal
2	TTN	Ssm	98	366	26.8%	cbioportal
3	CTNNB1	Ssm	95	366	26%	cbioportal
4	MUC16	Ssm	60	366	16.4%	cbioportal
5	ALB	Ssm	47	366	12.8%	cbioportal
6	PCLO	Ssm	39	366	10.7%	cbioportal
7	RYR2	Ssm	37	366	10.1%	cbioportal
8	APOB	Ssm	35	366	9.6%	cbioportal
9	OBSCN	Ssm	35	366	9.6%	cbioportal
10	LRP1B	Ssm	33	366	9%	cbioportal
11	FLG	Ssm	32	366	8.7%	cbioportal
12	ABCA13	Ssm	31	366	8.5%	cbioportal
13	CSMD3	Ssm	30	366	8.2%	cbioportal
14	ARID1A	Ssm	29	366	7.9%	cbioportal
16	XIRP2	Ssm	29	366	7.9%	cbioportal
15	CACNA1E	Ssm	29	366	7.9%	cbioportal
17	FAT3	Ssm	27	366	7.4%	cbioportal
19	HMCN1	Ssm	26	366	7.1%	cbioportal
18	ADGRV1	Ssm	26	366	7.1%	cbioportal
20	AXIN1	Ssm	25	366	6.8%	cbioportal
22	USH2A	Ssm	25	366	6.8%	cbioportal
21	SPTA1	Ssm	25	366	6.8%	cbioportal
23	PRKDC	Ssm	24	366	6.6%	cbioportal
24	RYR1	Ssm	24	366	6.6%	cbioportal
25	CSMD1	Ssm	23	366	6.3%	cbioportal
26	DNAH7	Ssm	23	366	6.3%	cbioportal
27	DOCK2	Ssm	23	366	6.3%	cbioportal
28	CUBN	Ssm	22	366	6%	cbioportal
29	HERC2	Ssm	22	366	6%	cbioportal
30	FBN2	Ssm	21	366	5.7%	cbioportal

Data updated 23 days agoSource updated 2026-06-03