PIK3CA

← targets

Samotolisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Pilaralisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Pictilisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Omipalisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Izorlisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Inavolisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Dactolisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Copanlisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Buparlisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Apitolisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Alpelisibsmall_molecule

—

INHIBITOR

—

Curated

Malignant Neoplasm,Solid Neoplasm,Malignant Breast Neoplasm+2

PIK3CA has variant …HAS_VARIANTderived200 of 788show all (up to 200)
→ has variant	Mutationother 44 accepted CIViC evidence items	—	—	Malignant Neoplasm,Solid Neoplasm,Malignant Breast Neoplasm+2	44	Curated	civic	graph →
→ has variant	H1047RSNV 30 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Head and Neck Neoplasm,Head and Neck Squamous Cell Carcinoma+2	30	Curated	civic	graph →
→ has variant	E545KSNV 29 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Breast Neoplasm,Melanoma+2	29	Curated	civic	graph →
→ has variant	E542KSNV 15 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Head and Neck Squamous Cell Carcinoma,Malignant Thyroid Gland Neoplasm+2	15	Curated	civic	graph →
→ has variant	K111NSNV 12 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,HER2-Positive Breast Carcinoma	12	Curated	civic	graph →
→ has variant	H1047LSNV 7 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Breast Tubular Carcinoma,Malignant Colorectal Neoplasm	7	Curated	civic	graph →
→ has variant	C420RSNV 6 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Colorectal Neoplasm,HER2-Positive Breast Carcinoma	6	Curated	civic	graph →
→ has variant	Exon 10 Mutation 6 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Colorectal Neoplasm,Rectal Carcinoma	6	Curated	civic	graph →
→ has variant	Exon 21 Mutation 6 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Colorectal Neoplasm,Rectal Carcinoma	6	Curated	civic	graph →
→ has variant	Amplificationamplification 5 accepted CIViC evidence items	—	—	Gastric Carcinoma,Head and Neck Squamous Cell Carcinoma,Ovarian Carcinoma+2	5	Curated	civic	graph →
→ has variant	Overexpressionexpression 5 accepted CIViC evidence items	—	—	Melanoma,HER2-Positive Breast Carcinoma	5	Curated	civic	graph →
→ has variant	E545GSNV 3 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Melanoma	3	Curated	civic	graph →
→ has variant	R88QSNV 3 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Colorectal Neoplasm	3	Curated	civic	graph →
→ has variant	E545ASNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ has variant	E545DSNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ has variant	E545QSNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has variant	G1049RSNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has variant	H1047YSNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ has variant	I391MSNV 2 accepted CIViC evidence items	—	—	HER2-Positive Breast Carcinoma	2	Curated	civic	graph →
→ has variant	N345KSNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has variant	Q546ESNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ has variant	Q546KSNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has variant	Q546RSNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ has variant	C604RSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	D350GSNV 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	D350NSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	E453ASNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	E453DSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	E453GSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	E453KSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	E453QSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	E453VSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	E542ASNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	E542DSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	E542GSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	E542QSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	E542RSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	E542VSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	E545LSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	E545RSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	E545VSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	E81KSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	F930SSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	G1007RSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	G1049ASNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	G1049CSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	G1049DSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	G1049SSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	G106ASNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	G106DSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	G106RSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	G106SSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	G106VSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	G118DSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	H1047DSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	H1047ISNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	H1047NSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	H1047PSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	H1047QSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	H1047TSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	K111ESNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	K111RSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	K944NSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	K966ESNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	L938*SNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	M1043ISNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	M1043TSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	M1043VSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	N1044KSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	N345DSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	N345HSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	N345ISNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	N345SSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	N345TSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	N345YSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	P471LSNV 1 accepted CIViC evidence items	—	—	Merkel Cell Carcinoma	1	Curated	civic	graph →
→ has variant	Q546HSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	Q546LSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	Q546PSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	R93WSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	Rare Mutation 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	S158LSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	V955GSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	V955ISNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	Wildtypeother 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	Activation mutation no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C971RSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D549NSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D939GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E365KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E39KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E545 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E545XSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G363ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	H1047L or H1047R no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	H1047XSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	H1-47R no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	I112NSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000003.11:g.(?_178916538)_(178952500_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000003.11:g.(?_178941859)_(178952162_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1002C>G (p.Leu334=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1004_1005del (p.Arg335fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1014T>G (p.Ile338Met)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1026C>G (p.Thr342=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1029C>T (p.Tyr343=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1030G>A (p.Val344Met)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1031T>G (p.Val344Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1033A>T (p.Asn345Tyr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.103G>C (p.Glu35Gln)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1055A>T (p.Asp352Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1056T>C (p.Asp352=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1059+12T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1059+12T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1059+19G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1060-12T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1060-17C>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1060-18_1060-17delinsAAindel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1060-8T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1060-8T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1060-9T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1064A>G (p.Tyr355Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1066G>A (p.Val356Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1071A>G (p.Arg357=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1076G>A (p.Gly359Asp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1082A>G (p.Tyr361Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1093G>A (p.Glu365Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1097C>G (p.Pro366Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1098C>A (p.Pro366=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1104T>C (p.Cys368=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1122A>G (p.Gln374=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1125A>G (p.Arg375=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.112C>T (p.Arg38Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1130C>G (p.Pro377Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1130C>T (p.Pro377Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1132T>C (p.Cys378Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1133G>A (p.Cys378Tyr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1136C>G (p.Ser379Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1139A>G (p.Asn380Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1139A>T (p.Asn380Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.113G>A (p.Arg38His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1143C>G (p.Pro381=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1145+13A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1145+14T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1145+16G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1145+19T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1145+4A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1145+9G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1145+9G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1145G>A (p.Arg382Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1146-17T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1146-30G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1146-3T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1146-4A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1146-955A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.115G>A (p.Glu39Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1175A>G (p.Tyr392Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1189C>T (p.Pro397Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1193G>A (p.Arg398His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1193G>C (p.Arg398Pro)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1203A>C (p.Arg401=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1203A>G (p.Arg401=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1215C>T (p.Ser405=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1232G>C (p.Gly411Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1234C>A (p.Arg412=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1235G>T (p.Arg412Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1244C>T (p.Ala415Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1248A>G (p.Lys416=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1251+1G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1251+3A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1251+5deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1251+8_1251+11deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1251+9T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1252-10G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1252G>A (p.Glu418Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1254A>G (p.Glu418=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1259_1264del (p.Cys420_Pro421del)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1263A>G (p.Pro421=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1269A>T (p.Ala423=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1279A>G (p.Ile427Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1292A>T (p.Asp431Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1299A>G (p.Thr433=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1304C>T (p.Thr435Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1305T>C (p.Thr435=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1306C>G (p.Leu436Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1308A>G (p.Leu436=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1321A>G (p.Met441Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1324G>A (p.Ala442Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1324G>C (p.Ala442Pro)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1341A>C (p.Pro447=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1342G>A (p.Val448Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1343_1357del (p.Val448_Leu452del)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1345C>T (p.Pro449Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.134T>C (p.Ile45Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1356AGA[1] (p.Glu453del)other no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1356A>G (p.Leu452=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1357G>A (p.Glu453Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1359_1373del (p.Glu453_Pro458delinsAsp)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1374T>A (p.Pro458=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.1384A>G (p.Thr462Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006218.4(PIK3CA):c.-138C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

PIK3CA has variant …HAS_VARIANTderived200 of 788show all (up to 200)

→ has variant

Mutationother

44 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Malignant Head and Neck Neoplasm,Head and Neck Squamous Cell Carcinoma+2

→ has variant

H1047RSNV

30 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Malignant Breast Neoplasm,Melanoma+2

→ has variant

E545KSNV

29 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Head and Neck Squamous Cell Carcinoma,Malignant Thyroid Gland Neoplasm+2

→ has variant

E542KSNV

15 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,HER2-Positive Breast Carcinoma

→ has variant

K111NSNV

12 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Breast Tubular Carcinoma,Malignant Colorectal Neoplasm

→ has variant

H1047LSNV

7 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Malignant Colorectal Neoplasm,HER2-Positive Breast Carcinoma

→ has variant

C420RSNV

6 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Malignant Colorectal Neoplasm,Rectal Carcinoma

→ has variant

Exon 10 Mutation

6 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Malignant Colorectal Neoplasm,Rectal Carcinoma

→ has variant

Exon 21 Mutation

6 accepted CIViC evidence items

—

Curated

Gastric Carcinoma,Head and Neck Squamous Cell Carcinoma,Ovarian Carcinoma+2

→ has variant

Amplificationamplification

5 accepted CIViC evidence items

—

Curated

Melanoma,HER2-Positive Breast Carcinoma

→ has variant

Overexpressionexpression

5 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Melanoma

→ has variant

E545GSNV

3 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Malignant Colorectal Neoplasm

→ has variant

R88QSNV

3 accepted CIViC evidence items

—

Curated

→ has variant

E545ASNV

2 accepted CIViC evidence items

—

Curated

→ has variant

E545DSNV

2 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Malignant Colorectal Neoplasm

→ has variant

E545QSNV

2 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Malignant Colorectal Neoplasm

→ has variant

G1049RSNV

2 accepted CIViC evidence items

—

Curated

→ has variant

H1047YSNV

2 accepted CIViC evidence items

—

Curated

HER2-Positive Breast Carcinoma

→ has variant

I391MSNV

2 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Malignant Colorectal Neoplasm

→ has variant

N345KSNV

2 accepted CIViC evidence items

—

Curated

→ has variant

Q546ESNV

2 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Malignant Colorectal Neoplasm

→ has variant

Q546KSNV

2 accepted CIViC evidence items

—

Curated

→ has variant

Q546RSNV

2 accepted CIViC evidence items

—

Curated

→ has variant

C604RSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

D350GSNV

1 accepted CIViC evidence items

—

Melanoma

Curated

→ has variant

D350NSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

E453ASNV

1 accepted CIViC evidence items

—

Curated

→ has variant

E453DSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

E453GSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

E453KSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

E453QSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

E453VSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

E542ASNV

1 accepted CIViC evidence items

—

Curated

→ has variant

E542DSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

E542GSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

E542QSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

E542RSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

E542VSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

E545LSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

E545RSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

E545VSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

E81KSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

F930SSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

G1007RSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

G1049ASNV

1 accepted CIViC evidence items

—

Curated

→ has variant

G1049CSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

G1049DSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

G1049SSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

G106ASNV

1 accepted CIViC evidence items

—

Curated

→ has variant

G106DSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

G106RSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

G106SSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

G106VSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

G118DSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

H1047DSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

H1047ISNV

1 accepted CIViC evidence items

—

Curated

→ has variant

H1047NSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

H1047PSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

H1047QSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

H1047TSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

K111ESNV

1 accepted CIViC evidence items

—

Curated

→ has variant

K111RSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

K944NSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

K966ESNV

1 accepted CIViC evidence items

—

Curated

→ has variant

L938*SNV

1 accepted CIViC evidence items

—

Curated

→ has variant

M1043ISNV

1 accepted CIViC evidence items

—

Curated

→ has variant

M1043TSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

M1043VSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

N1044KSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

N345DSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

N345HSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

N345ISNV

1 accepted CIViC evidence items

—

Curated

→ has variant

N345SSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

N345TSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

N345YSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

P471LSNV

1 accepted CIViC evidence items

—

Merkel Cell Carcinoma

Curated

→ has variant

Q546HSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

Q546LSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

Q546PSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

R93WSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

Rare Mutation

1 accepted CIViC evidence items

—

Curated

→ has variant

S158LSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

V955GSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

V955ISNV

1 accepted CIViC evidence items

—

Curated

→ has variant

Wildtypeother

1 accepted CIViC evidence items

—

Curated

→ has variant

Activation mutation

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

C971RSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D549NSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D939GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E365KSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E39KSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E545

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E545XSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G363ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

H1047L or H1047R

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

H1047XSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

H1-47R

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

I112NSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NC_000003.11:g.(?_178916538)_(178952500_?)dupinsertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NC_000003.11:g.(?_178941859)_(178952162_?)dupinsertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1002C>G (p.Leu334=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_006218.4(PIK3CA):c.1004_1005del (p.Arg335fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1014T>G (p.Ile338Met)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1026C>G (p.Thr342=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1029C>T (p.Tyr343=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1030G>A (p.Val344Met)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1031T>G (p.Val344Gly)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1033A>T (p.Asn345Tyr)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.103G>C (p.Glu35Gln)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1055A>T (p.Asp352Val)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1056T>C (p.Asp352=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1059+12T>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1059+12T>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1059+19G>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1060-12T>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1060-17C>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1060-18_1060-17delinsAAindel

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1060-8T>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1060-8T>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1060-9T>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1064A>G (p.Tyr355Cys)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1066G>A (p.Val356Ile)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1071A>G (p.Arg357=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1076G>A (p.Gly359Asp)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1082A>G (p.Tyr361Cys)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1093G>A (p.Glu365Lys)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1097C>G (p.Pro366Arg)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1098C>A (p.Pro366=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1104T>C (p.Cys368=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1122A>G (p.Gln374=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1125A>G (p.Arg375=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.112C>T (p.Arg38Cys)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1130C>G (p.Pro377Arg)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1130C>T (p.Pro377Leu)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1132T>C (p.Cys378Arg)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1133G>A (p.Cys378Tyr)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1136C>G (p.Ser379Cys)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1139A>G (p.Asn380Ser)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1139A>T (p.Asn380Ile)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.113G>A (p.Arg38His)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1143C>G (p.Pro381=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1145+13A>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1145+14T>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1145+16G>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1145+19T>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1145+4A>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1145+9G>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1145+9G>TSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1145G>A (p.Arg382Lys)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1146-17T>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1146-30G>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1146-3T>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1146-4A>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1146-955A>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.115G>A (p.Glu39Lys)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1175A>G (p.Tyr392Cys)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1189C>T (p.Pro397Ser)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1193G>A (p.Arg398His)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1193G>C (p.Arg398Pro)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1203A>C (p.Arg401=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1203A>G (p.Arg401=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1215C>T (p.Ser405=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1232G>C (p.Gly411Ala)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1234C>A (p.Arg412=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1235G>T (p.Arg412Leu)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1244C>T (p.Ala415Val)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1248A>G (p.Lys416=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1251+1G>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1251+3A>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_006218.4(PIK3CA):c.1251+5deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_006218.4(PIK3CA):c.1251+8_1251+11deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1251+9T>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1252-10G>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1252G>A (p.Glu418Lys)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1254A>G (p.Glu418=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_006218.4(PIK3CA):c.1259_1264del (p.Cys420_Pro421del)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1263A>G (p.Pro421=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1269A>T (p.Ala423=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1279A>G (p.Ile427Val)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1292A>T (p.Asp431Val)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1299A>G (p.Thr433=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1304C>T (p.Thr435Ile)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1305T>C (p.Thr435=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1306C>G (p.Leu436Val)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1308A>G (p.Leu436=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1321A>G (p.Met441Val)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1324G>A (p.Ala442Thr)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1324G>C (p.Ala442Pro)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1341A>C (p.Pro447=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1342G>A (p.Val448Ile)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_006218.4(PIK3CA):c.1343_1357del (p.Val448_Leu452del)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1345C>T (p.Pro449Ser)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.134T>C (p.Ile45Thr)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1356AGA[1] (p.Glu453del)other

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1356A>G (p.Leu452=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1357G>A (p.Glu453Lys)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_006218.4(PIK3CA):c.1359_1373del (p.Glu453_Pro458delinsAsp)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1374T>A (p.Pro458=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.1384A>G (p.Thr462Ala)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_006218.4(PIK3CA):c.-138C>TSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

Lung Squamous Cell Carcinoma

PIK3CA altered in cohorts of …ALTERED_INderived15 of 27show all (up to 200)
→ altered in cohorts of	Lung Squamous Cell Carcinoma 442 / 504 cases (88 %) · ssm · TCGA-LUSC · largest of 5 cohorts	—	—	Lung Squamous Cell Carcinoma	5	Observed	gdc	graph →
→ altered in cohorts of	Cervical Carcinoma 248 / 306 cases (81 %) · ssm · TCGA-CESC · largest of 2 cohorts	—	—	Cervical Carcinoma	2	Observed	gdc	graph →
→ altered in cohorts of	Uterine Carcinosarcoma 46 / 57 cases (81 %) · ssm · TCGA-UCS	—	—	Uterine Carcinosarcoma	1	Observed	gdc	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinomasubtype 390 / 528 cases (74 %) · ssm · TCGA-HNSC · largest of 5 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	5	Observed	gdc	graph →
→ altered in cohorts of	Esophageal Carcinoma 130 / 185 cases (70 %) · ssm · TCGA-ESCA	—	—	Esophageal Carcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Endometrial Carcinoma 824 / 1,882 cases (44 %) · ssm · ucec_ancestry_cds_msk_2023 · largest of 11 cohorts	—	—	Endometrial Carcinoma	11	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 105 / 247 cases (43 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 1,401 / 3,879 cases (36 %) · ssm · breast_msk_2025 · largest of 19 cohorts	—	—	Invasive Breast Carcinoma	19	Observed	cbioportal	graph →
→ altered in cohorts of	Uterine Malignant Mixed Mesodermal (Mullerian) Tumor 20 / 57 cases (35 %) · ssm · ucs_tcga · largest of 3 cohorts	—	—	Uterine Malignant Mixed Mesodermal (Mullerian) Tumor	3	Observed	cbioportal	graph →
→ altered in cohorts of	Malignant Breast Neoplasmcancer_family 52 / 174 cases (30 %) · ssm · CMI-MBC	—	—	Malignant Breast Neoplasm	1	Observed	gdc	graph →
→ altered in cohorts of	Colon Adenocarcinoma 127 / 429 cases (30 %) · ssm · coad_tcga_gdc · largest of 4 cohorts	—	—	Colon Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Cervical Squamous Cell Carcinoma 83 / 291 cases (29 %) · ssm · cesc_tcga_pan_can_atlas_2018 · largest of 3 cohorts	—	—	Cervical Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 103 / 474 cases (22 %) · ssm · blca_msk_tcga_2020 · largest of 14 cohorts	—	—	Bladder Urothelial Carcinoma	14	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 1,486 / 7,237 cases (21 %) · ssm · crc_msk_2026 · largest of 2 cohorts	—	—	Rectal Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 229 / 1,134 cases (20 %) · ssm · crc_msk_2017 · largest of 10 cohorts	—	—	Colorectal Adenocarcinoma	10	Observed	cbioportal	graph →

PIK3CA altered in cohorts of …ALTERED_INderived15 of 27show all (up to 200)

→ altered in cohorts of

442 / 504 cases (88 %) · ssm · TCGA-LUSC · largest of 5 cohorts

—

Lung Squamous Cell Carcinoma

Observed

gdc