PIK3CA D939G

CI-VAR-00000610Explore in graph →NP_006209.2:p.Asp939GlyNM_006218.4:c.2816A>GCIViC 3293

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
PIK3CA D939G	(functional)	Functional	D	Supports Gain Of Function	2	submitted	EID9176 In an analysis of recurrent mutations in breast cancer, the previously unknown PIK3CA D939G mutation was identified. Expression of D939G in MCF10A mammary epithelial cells resulted in increased phosph… (full text at CIViC) PMID 30205045 · Razavi et al., 2018 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.