PIK3CA G363A

CI-VAR-00001724Explore in graph →NP_006209.2:p.Gly363AlaNM_006218.4:c.1088G>CCIViC 2788

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Head and Neck Neoplasm1
PIK3CA G363A	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	submitted	EID7548 Whole-exome sequencing of 151 HNSCC tumours found a high frequency of mutations in PI3K pathway genes. Four novel mutation were found, including PIK3CA p.G363A. Stable transformation of HNSCC cell lin… (full text at CIViC) PMID 23619167 · Lui et al., 2013 · Open in CIViC	civic
Unmapped disease1unmapped disease
PIK3CA G363A	(functional)	Functional	D	Supports Gain Of Function	2	submitted	EID10737 Whole-exome sequencing of 151 HNSCC tumours found a high frequency of mutations in PI3K pathway genes. Four novel mutation were found, including PIK3CA p.G363A. Stable transformation of HNSCC cell lin… (full text at CIViC) PMID 23619167 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.