PIK3CA C604R

CI-VAR-00000320Explore in graph →CIViC 3337

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
PIK3CA C604R	(functional)	Functional	D	Supports Gain Of Function	2	accepted	EID9325 A functional screen of mutations found in large-scale cancer data sets identified PIK3CA C604R as an activating mutation, as measured by growth-factor independent growth in Ba/F3 and MCF10A cells. PMID 29533785 · Ng et al., 2018 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.