PIK3CA NM_006218.4(PIK3CA):c.1093G>A (p.Glu365Lys)

CI-VAR-00066735Explore in graph →p.Glu365LysNM_006218.4:c.1093G>AClinVar 419222 rs1064793732

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
419222	Pathogenic	criteria provided, multiple submitters, no conflicts	2	Ovarian neoplasm; Cowden syndrome; Megalencephaly-capillary malformation-polymicrogyria syndrome; Angioosteohypertrophic syndrome; PIK3CA-related disorder; PIK3CA related overgrowth syndrome; Neoplasm	germline/somatic	11	Jun 05, 2025	clinvar