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CancerIndexthe global index of cancer

Cancers Data Trials Drugs Genes Biomarkers Approvals Rankings Research gap Graph

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CancerIndex

CancerIndex is a research and information platform. It is not a physician, does not diagnose, and does not recommend treatment. Population statistics do not predict individual outcomes.

Every number links to its source and retrieval date. Derived metrics carry a formula version. AI-generated synthesis is not enabled in this phase; all content is database-grounded.

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HER2-Positive Breast Carcinoma · CancerIndex

Cancers
Neoplasm
Neoplasm by Special Category
Malignant Neoplasm
Malignant Breast Neoplasm
Breast Carcinoma
Breast Adenocarcinoma
Breast Carcinoma by Gene Expression Profile
HER2-Positive Breast Carcinoma

Molecular Subtype

HER2-Positive Breast Carcinoma

CI-CAN-00007795Explore in graph →

140 active trials3 approved drugs93 evidence items

NCIt: C53556
DOID: 0060079

Overview
Statistics
Survival
Genomics
Variants & evidence93
Drugs20
Trials377
Research
Rankings
Sources & provenance

Data completeness4 / 7 dimensions

Epidemiology (no data yet)
Survival (no data yet)
Trials (data present)
Literature (data present)
Genomics (no data yet)
Evidence (data present)
Therapies (data present)

Computed from entity_counters.completeness · refreshed after each connector run

Definition

What this entity is

A biologic subset of breast carcinoma defined by high expression of HER2, GRB7, and TRAP100, and by lack of expression of estrogen receptor (ER).

Definition text as published by ncit-evsProvenance

Source: NCI Thesaurus (NCIt)
Dataset: NCI Thesaurus
Version: 26.08e
Retrieved: Sep 8, 2026
Layer: raw (as published)
Evidence: expert curation
License: CC BY 4.0
Run: ING-NCITEVS-20260908-000001

Open at source Curated

Data updated 22 days agoSource updated 26.08e

Taxonomy

Position in the hierarchies

Several hierarchies coexist; edges are listed per hierarchy type with their source.

Parents

ncit

Breast Carcinoma by Gene Expression ProfileSubtype

Children (1)

ncit

Early Stage HER2-Positive Breast Carcinoma

Anatomy

Anatomical sites

BreastC12971

Record

Identity

CancerIndex ID: CI-CAN-00007795
Entity type: Molecular Subtype
Malignant: Yes
Solid / hematologic: Solid tumor
Pediatric relevant: Not flagged
Rare cancer: Unknown (no incidence data yet)
Hierarchy depth: 7
Classification version: 26.08e
Semantic types: Neoplastic Process
Status: Active
Record updated: 2026-09-08

Coverage

Data completeness

Trials (all / active)

377 / 140

Publications (all / 5y)

4,992 / 2,511

Evidence items

93

Genes / variants

8 / 19

Drugs (any / approved)

20 / 3

Genomic cohorts

0

Epidemiology / survival obs.

0 / 0

Data updated 15 minutes agoSource updated unknowncounters aggregate over descendants

Names

Synonyms (4)

ERBB2 Overexpressing Subtype of Breast Carcinomasynonym · NCIt
HER2 Overexpressing Breast Carcinomasynonym · NCIt
HER2 Overexpressing Subtype of Breast Carcinomasynonym · NCIt
HER2 Positive Breast Cancersynonym · NCIt

CancerIndex is a research and information platform. It does not diagnose and does not recommend treatment.

Key figures

At a glance

Each figure carries its unit, period and source; ranks link to "Why this rank?".

US deaths43,897countUnited States · 2024 · both sexes · all agescdc-wonderObservedrank #3 of 31 (USA · both sexes · all ages · 2024 · top-level cancers)figures shown for Malignant Breast Neoplasm (registry level) — open Malignant Breast Neoplasm
US new cases291,057countUnited States · 2023 · both sexes · all agescdc-uscsObservedrank #1 of 32 (USA · both sexes · all ages · 2023 · top-level cancers)figures shown for Malignant Breast Neoplasm (registry level) — open Malignant Breast Neoplasm
US age-standardized mortality10.2per 100,000United States · 2024 · both sexes · all ages · 2000 U.S. Std. Populationcdc-wonderObservedrank #3 of 23 (USA · both sexes · all ages · 2024 · top-level cancers)figures shown for Malignant Breast Neoplasm (registry level) — open Malignant Breast Neoplasm
Active trials140countcurrent registry status · entity + descendantsclinicaltrialsComputedrank #165 of 1,654 (World · both sexes · all ages · latest · all malignant entities)
Recruiting trials73countstatus RECRUITING · entity + descendantsclinicaltrialsComputedrank #166 of 1,277 (World · both sexes · all ages · latest · all malignant entities)
Curated evidence items93countaccepted CIViC items · entity + descendantscivicComputedrank #49 of 492 (World · both sexes · all ages · latest · all malignant entities)
Publications, last 12 months568countPubMed records · stored query · 12-month windowpubmedComputedrank #134 of 2,294 (World · both sexes · all ages · latest · all malignant entities)
Genomic cohorts0countopen GDC projects · entity + descendantsgdcComputednot in a current ranking snapshot

Data updated 15 minutes agoSource updated unknownregistry figures: cdc-uscs · latest year available per metric · counters aggregate over descendants