Malignant Pancreatic Neoplasm — Genomics

Malignant Pancreatic Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

14 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Acinar Cell Carcinoma of the Pancreas (JHU, J Pathol 2014) paac_jhu_2014JHU

23 cases with simple somatic mutation data · 23 cases total · 2026-01-12 · mapped to Pancreatic Acinar Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SMAD4

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Metastatic Pancreatic Adenocarcinoma (PRINCE Trial, Nat Med. 2022) - iAtlas Harmonized paad_iatlas_prince_2022

93 cases with simple somatic mutation data · 93 cases total · 2026-02-16 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	68	93	73.1%	cbioportal
2	TP53	Ssm	64	93	68.8%	cbioportal
3	NBPF14	Ssm	30	93	32.3%	cbioportal
4	CDKN2A	Ssm	25	93	26.9%	cbioportal
5	MUC17	Ssm	21	93	22.6%	cbioportal
6	TTN	Ssm	20	93	21.5%	cbioportal
7	DEAF1	Ssm	18	93	19.4%	cbioportal
8	AHNAK	Ssm	17	93	18.3%	cbioportal
9	NBPF1	Ssm	16	93	17.2%	cbioportal
10	PHLPP1	Ssm	14	93	15.1%	cbioportal
11	AHNAK2	Ssm	13	93	14%	cbioportal
12	CENPB	Ssm	13	93	14%	cbioportal
14	SMAD4	Ssm	12	93	12.9%	cbioportal
13	MUC5AC	Ssm	12	93	12.9%	cbioportal
15	ZNF208	Ssm	12	93	12.9%	cbioportal
17	TCHH	Ssm	11	93	11.8%	cbioportal
16	MUC16	Ssm	11	93	11.8%	cbioportal
19	NBPF10	Ssm	10	93	10.8%	cbioportal
18	FLG2	Ssm	10	93	10.8%	cbioportal
20	RAMP2	Ssm	10	93	10.8%	cbioportal
22	ZNF594	Ssm	9	93	9.7%	cbioportal
21	DGKZ	Ssm	9	93	9.7%	cbioportal
30	USH2A	Ssm	8	93	8.6%	cbioportal
23	EIF3J	Ssm	8	93	8.6%	cbioportal
24	EPAS1	Ssm	8	93	8.6%	cbioportal
25	FLG	Ssm	8	93	8.6%	cbioportal
26	HRNR	Ssm	8	93	8.6%	cbioportal
27	OBSCN	Ssm	8	93	8.6%	cbioportal
28	SAAL1	Ssm	8	93	8.6%	cbioportal
29	STUM	Ssm	8	93	8.6%	cbioportal

Data updated 22 days agoSource updated 2026-02-16

Pancreatic Acinar Cell Carcinoma (MSK, JCO 2023) paac_msk_jco_2023MSK

47 cases with simple somatic mutation data · 47 cases total · 2026-01-12 · mapped to Pancreatic Acinar Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SMAD4	Ssm	8	47	17%	cbioportal
3	CTNNB1	Ssm	6	47	12.8%	cbioportal
2	AXIN1	Ssm	6	47	12.8%	cbioportal
6	RB1	Ssm	5	47	10.6%	cbioportal
4	NF1	Ssm	5	47	10.6%	cbioportal
5	PRKAR1A	Ssm	5	47	10.6%	cbioportal
7	CREBBP	Ssm	4	47	8.5%	cbioportal
9	PTEN	Ssm	4	47	8.5%	cbioportal
8	PBRM1	Ssm	4	47	8.5%	cbioportal
155	SLFN11	Ssm	1	13	7.7%	cbioportal
172	ZNRF3	Ssm	1	13	7.7%	cbioportal
93	GNB1	Ssm	1	13	7.7%	cbioportal
154	SETDB1	Ssm	1	13	7.7%	cbioportal
19	MGA	Ssm	3	46	6.5%	cbioportal
18	MEN1	Ssm	3	47	6.4%	cbioportal
10	ARID1A	Ssm	3	47	6.4%	cbioportal
11	ASXL1	Ssm	3	47	6.4%	cbioportal
12	ATM	Ssm	3	47	6.4%	cbioportal
13	BRAF	Ssm	3	47	6.4%	cbioportal
14	BRCA2	Ssm	3	47	6.4%	cbioportal
15	CDKN2A	Ssm	3	47	6.4%	cbioportal
16	IKBKE	Ssm	3	47	6.4%	cbioportal
17	KMT2D	Ssm	3	47	6.4%	cbioportal
20	NRAS	Ssm	3	47	6.4%	cbioportal
21	PIK3CG	Ssm	3	47	6.4%	cbioportal
22	POLE	Ssm	3	47	6.4%	cbioportal
23	RARA	Ssm	3	47	6.4%	cbioportal
24	SETD2	Ssm	3	47	6.4%	cbioportal
25	TP53	Ssm	3	47	6.4%	cbioportal
26	TSC2	Ssm	3	47	6.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Adenocarcinoma TCGA-PAADTCGA

185 cases with simple somatic mutation data · 185 cases total · Data Release 46.0 · mapped to Pancreatic Adenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	124	185	67%	gdc
2	KRAS	Ssm	123	185	66.5%	gdc
3	SMAD4	Ssm	119	185	64.3%	gdc
4	CDKN2A	Ssm	117	185	63.2%	gdc
8	MAPK4	Ssm	114	185	61.6%	gdc
10	MBD1	Ssm	114	185	61.6%	gdc
6	SKA1	Ssm	114	185	61.6%	gdc
5	ME2	Ssm	114	185	61.6%	gdc
7	CXXC1	Ssm	114	185	61.6%	gdc
9	CFAP53	Ssm	114	185	61.6%	gdc
18	MBD2	Ssm	113	185	61.1%	gdc
11	C18orf54	Ssm	113	185	61.1%	gdc
19	POLI	Ssm	113	185	61.1%	gdc
12	MRO	Ssm	113	185	61.1%	gdc
17	STARD6	Ssm	113	185	61.1%	gdc
14	DCC	Ssm	113	185	61.1%	gdc
15	MEX3C	Ssm	113	185	61.1%	gdc
13	TCF4	Ssm	113	185	61.1%	gdc
16	MYO5B	Ssm	113	185	61.1%	gdc
27	SERPINB10	Ssm	112	185	60.5%	gdc
25	SERPINB7	Ssm	112	185	60.5%	gdc
20	DYM	Ssm	112	185	60.5%	gdc
22	SMAD7	Ssm	112	185	60.5%	gdc
26	AC091551.1	Ssm	112	185	60.5%	gdc
21	RAB27B	Ssm	112	185	60.5%	gdc
28	ELAC1	Ssm	112	185	60.5%	gdc
29	CCDC68	Ssm	112	185	60.5%	gdc
30	LIPG	Ssm	112	185	60.5%	gdc
23	ALPK2	Ssm	112	185	60.5%	gdc
24	DYNAP	Ssm	112	185	60.5%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Pancreatic Adenocarcinoma (ICGC, Nature 2012) paad_icgcICGC

99 cases with simple somatic mutation data · 99 cases total · 2026-01-12 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	94	99	94.9%	cbioportal
2	TP53	Ssm	33	99	33.3%	cbioportal
3	SMAD4	Ssm	16	99	16.2%	cbioportal
4	TTN	Ssm	12	99	12.1%	cbioportal
5	CSMD1	Ssm	5	99	5.1%	cbioportal
6	MUC16	Ssm	5	99	5.1%	cbioportal
12	RYR3	Ssm	4	99	4%	cbioportal
11	PCDH15	Ssm	4	99	4%	cbioportal
10	NALCN	Ssm	4	99	4%	cbioportal
9	HMCN1	Ssm	4	99	4%	cbioportal
8	DNAH5	Ssm	4	99	4%	cbioportal
7	ARID1A	Ssm	4	99	4%	cbioportal
14	TGFBR2	Ssm	4	99	4%	cbioportal
13	SF3B1	Ssm	4	99	4%	cbioportal
15	ABCA12	Ssm	3	99	3%	cbioportal
22	LRP1B	Ssm	3	99	3%	cbioportal
21	FLG	Ssm	3	99	3%	cbioportal
23	MAP2K4	Ssm	3	99	3%	cbioportal
24	NBAS	Ssm	3	99	3%	cbioportal
25	OR2M5	Ssm	3	99	3%	cbioportal
26	PCDHB6	Ssm	3	99	3%	cbioportal
29	THSD7A	Ssm	3	99	3%	cbioportal
30	XIRP2	Ssm	3	99	3%	cbioportal
31	ZFHX4	Ssm	3	99	3%	cbioportal
20	EPC1	Ssm	3	99	3%	cbioportal
19	DMD	Ssm	3	99	3%	cbioportal
18	COL6A5	Ssm	3	99	3%	cbioportal
17	ARID2	Ssm	3	99	3%	cbioportal
16	AFF2	Ssm	3	99	3%	cbioportal
28	SYNE1	Ssm	3	99	3%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Adenocarcinoma (MSK, 2025) paad_msk_2025MSK

29 cases with simple somatic mutation data · 29 cases total · 2026-02-10 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	18	29	62.1%	cbioportal
2	TP53	Ssm	14	29	48.3%	cbioportal
8	ZNF676	Ssm	3	16	18.8%	cbioportal
53	SMOC1	Ssm	2	16	12.5%	cbioportal
52	SDHAP1	Ssm	2	16	12.5%	cbioportal
48	PRDM5	Ssm	2	16	12.5%	cbioportal
32	HLA-G	Ssm	2	16	12.5%	cbioportal
33	KIF2B	Ssm	2	16	12.5%	cbioportal
20	DAB2	Ssm	2	16	12.5%	cbioportal
24	FAM86C1P	Ssm	2	16	12.5%	cbioportal
40	NOTCH2NLA	Ssm	2	16	12.5%	cbioportal
43	OR4C46	Ssm	2	16	12.5%	cbioportal
38	NBPF12	Ssm	2	16	12.5%	cbioportal
35	MARCHF7	Ssm	2	16	12.5%	cbioportal
6	KMT2C	Ssm	3	29	10.3%	cbioportal
7	RNF43	Ssm	3	29	10.3%	cbioportal
3	APC	Ssm	3	29	10.3%	cbioportal
4	CDK8	Ssm	3	29	10.3%	cbioportal
5	CDKN2A	Ssm	3	29	10.3%	cbioportal
31	HLA-C	Ssm	2	28	7.1%	cbioportal
23	ETAA1	Ssm	2	28	7.1%	cbioportal
47	PRDM14	Ssm	2	28	7.1%	cbioportal
51	RTEL1	Ssm	2	28	7.1%	cbioportal
55	USP8	Ssm	2	28	7.1%	cbioportal
9	ALB	Ssm	2	28	7.1%	cbioportal
46	PIK3R2	Ssm	2	29	6.9%	cbioportal
13	BAP1	Ssm	2	29	6.9%	cbioportal
12	AXIN1	Ssm	2	29	6.9%	cbioportal
11	ASXL1	Ssm	2	29	6.9%	cbioportal
10	ARID2	Ssm	2	29	6.9%	cbioportal

Data updated 22 days agoSource updated 2026-02-10

Pancreatic Adenocarcinoma (QCMG, Nature 2016) paad_qcmg_uq_2016QCMG

383 cases with simple somatic mutation data · 456 cases total · 2026-01-12 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	344	383	89.8%	cbioportal
2	TP53	Ssm	253	383	66.1%	cbioportal
3	SMAD4	Ssm	86	383	22.5%	cbioportal
4	CDKN2A	Ssm	71	383	18.5%	cbioportal
5	TTN	Ssm	56	383	14.6%	cbioportal
6	ARID1A	Ssm	29	383	7.6%	cbioportal
7	SYNE1	Ssm	27	383	7%	cbioportal
8	LRP1B	Ssm	22	383	5.7%	cbioportal
11	RYR1	Ssm	21	383	5.5%	cbioportal
10	RNF43	Ssm	21	383	5.5%	cbioportal
9	KMT2C	Ssm	21	383	5.5%	cbioportal
12	MUC16	Ssm	20	383	5.2%	cbioportal
13	FLG	Ssm	19	383	5%	cbioportal
14	HMCN1	Ssm	19	383	5%	cbioportal
15	KMT2D	Ssm	19	383	5%	cbioportal
19	TGFBR2	Ssm	18	383	4.7%	cbioportal
18	OBSCN	Ssm	18	383	4.7%	cbioportal
17	GLI3	Ssm	18	383	4.7%	cbioportal
16	FAT3	Ssm	18	383	4.7%	cbioportal
20	DNAH11	Ssm	16	383	4.2%	cbioportal
21	MUC4	Ssm	16	383	4.2%	cbioportal
22	RYR3	Ssm	16	383	4.2%	cbioportal
23	RYR2	Ssm	15	383	3.9%	cbioportal
24	ATM	Ssm	14	383	3.7%	cbioportal
26	WDFY4	Ssm	14	383	3.7%	cbioportal
25	CSMD1	Ssm	14	383	3.7%	cbioportal
30	TENM3	Ssm	13	383	3.4%	cbioportal
27	ADGRV1	Ssm	13	383	3.4%	cbioportal
28	CSMD3	Ssm	13	383	3.4%	cbioportal
29	DNAH5	Ssm	13	383	3.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Adenocarcinoma (TCGA, Firehose Legacy) paad_tcgaTCGA

150 cases with simple somatic mutation data · 186 cases total · 2026-01-12 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	136	150	90.7%	cbioportal
2	TP53	Ssm	104	150	69.3%	cbioportal
3	SMAD4	Ssm	37	150	24.7%	cbioportal
4	TTN	Ssm	35	150	23.3%	cbioportal
5	CDKN2A	Ssm	22	150	14.7%	cbioportal
8	RYR1	Ssm	11	150	7.3%	cbioportal
7	OBSCN	Ssm	11	150	7.3%	cbioportal
6	MUC16	Ssm	11	150	7.3%	cbioportal
11	GNAS	Ssm	10	150	6.7%	cbioportal
10	FLG	Ssm	10	150	6.7%	cbioportal
9	FAT2	Ssm	10	150	6.7%	cbioportal
20	USH2A	Ssm	9	150	6%	cbioportal
14	FAT3	Ssm	9	150	6%	cbioportal
12	ADAMTS16	Ssm	9	150	6%	cbioportal
13	CSMD2	Ssm	9	150	6%	cbioportal
15	FAT4	Ssm	9	150	6%	cbioportal
16	HMCN1	Ssm	9	150	6%	cbioportal
17	LRP1B	Ssm	9	150	6%	cbioportal
18	MYO18B	Ssm	9	150	6%	cbioportal
19	RNF43	Ssm	9	150	6%	cbioportal
23	CACNA1B	Ssm	8	150	5.3%	cbioportal
21	ADAMTS12	Ssm	8	150	5.3%	cbioportal
22	ARID1A	Ssm	8	150	5.3%	cbioportal
24	GLI3	Ssm	8	150	5.3%	cbioportal
25	HECW2	Ssm	8	150	5.3%	cbioportal
26	PLEC	Ssm	8	150	5.3%	cbioportal
27	RREB1	Ssm	8	150	5.3%	cbioportal
28	RYR3	Ssm	8	150	5.3%	cbioportal
29	SCN5A	Ssm	8	150	5.3%	cbioportal
30	TGFBR2	Ssm	8	150	5.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Adenocarcinoma (TCGA GDC, 2025) paad_tcga_gdcTCGA GDC

173 cases with simple somatic mutation data · 186 cases total · 2026-01-13 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	107	173	61.8%	cbioportal
2	TP53	Ssm	100	173	57.8%	cbioportal
3	SMAD4	Ssm	36	173	20.8%	cbioportal
4	CDKN2A	Ssm	30	173	17.3%	cbioportal
5	TTN	Ssm	25	173	14.5%	cbioportal
6	MUC16	Ssm	12	173	6.9%	cbioportal
7	RNF43	Ssm	11	173	6.4%	cbioportal
9	HECW2	Ssm	8	173	4.6%	cbioportal
8	ARID1A	Ssm	8	173	4.6%	cbioportal
10	RYR1	Ssm	8	173	4.6%	cbioportal
11	TGFBR2	Ssm	8	173	4.6%	cbioportal
17	KDM6A	Ssm	7	173	4%	cbioportal
18	LRP1B	Ssm	7	173	4%	cbioportal
19	PCDH15	Ssm	7	173	4%	cbioportal
20	RNF213	Ssm	7	173	4%	cbioportal
21	TPO	Ssm	7	173	4%	cbioportal
12	ATM	Ssm	7	173	4%	cbioportal
13	CACNA1B	Ssm	7	173	4%	cbioportal
14	FAT2	Ssm	7	173	4%	cbioportal
15	GLI3	Ssm	7	173	4%	cbioportal
16	GNAS	Ssm	7	173	4%	cbioportal
22	ADAMTS12	Ssm	6	173	3.5%	cbioportal
30	FLNC	Ssm	6	173	3.5%	cbioportal
29	FLG	Ssm	6	173	3.5%	cbioportal
28	FBN3	Ssm	6	173	3.5%	cbioportal
27	COL6A2	Ssm	6	173	3.5%	cbioportal
26	COL5A1	Ssm	6	173	3.5%	cbioportal
25	COL11A1	Ssm	6	173	3.5%	cbioportal
24	APBA2	Ssm	6	173	3.5%	cbioportal
23	ADAMTS16	Ssm	6	173	3.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas) paad_tcga_pan_can_atlas_2018TCGA

179 cases with simple somatic mutation data · 184 cases total · 2026-06-04 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	117	179	65.4%	cbioportal
2	TP53	Ssm	107	179	59.8%	cbioportal
3	SMAD4	Ssm	37	179	20.7%	cbioportal
4	CDKN2A	Ssm	35	179	19.6%	cbioportal
5	TTN	Ssm	29	179	16.2%	cbioportal
6	MUC16	Ssm	13	179	7.3%	cbioportal
7	RNF43	Ssm	11	179	6.1%	cbioportal
8	CSMD2	Ssm	10	179	5.6%	cbioportal
9	RYR1	Ssm	10	179	5.6%	cbioportal
10	ARID1A	Ssm	9	179	5%	cbioportal
11	PCDH15	Ssm	9	179	5%	cbioportal
12	ATM	Ssm	8	179	4.5%	cbioportal
13	CACNA1B	Ssm	8	179	4.5%	cbioportal
14	FLG	Ssm	8	179	4.5%	cbioportal
15	HECW2	Ssm	8	179	4.5%	cbioportal
16	MYO18B	Ssm	8	179	4.5%	cbioportal
19	TGFBR2	Ssm	8	179	4.5%	cbioportal
17	OBSCN	Ssm	8	179	4.5%	cbioportal
18	RNF213	Ssm	8	179	4.5%	cbioportal
25	FAT2	Ssm	7	179	3.9%	cbioportal
24	DSCAML1	Ssm	7	179	3.9%	cbioportal
23	DNAH11	Ssm	7	179	3.9%	cbioportal
22	COL6A2	Ssm	7	179	3.9%	cbioportal
21	APBA2	Ssm	7	179	3.9%	cbioportal
20	ADAMTS12	Ssm	7	179	3.9%	cbioportal
26	FAT3	Ssm	7	179	3.9%	cbioportal
30	KDM6A	Ssm	7	179	3.9%	cbioportal
29	GNAS	Ssm	7	179	3.9%	cbioportal
28	GLI3	Ssm	7	179	3.9%	cbioportal
27	FLNC	Ssm	7	179	3.9%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Pancreatic Cancer cfDNA (MSK, J Natl Cancer Inst 2025) pancreas_ctdna_msk_2025MSK

412 cases with simple somatic mutation data · 412 cases total · 2026-01-28 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	168	412	40.8%	cbioportal
2	TP53	Ssm	149	412	36.2%	cbioportal
3	CDKN2A	Ssm	37	412	9%	cbioportal
4	SMAD4	Ssm	34	412	8.3%	cbioportal
5	ARID1A	Ssm	24	412	5.8%	cbioportal
6	ATM	Ssm	23	412	5.6%	cbioportal
8	KDM6A	Ssm	9	412	2.2%	cbioportal
7	GNAS	Ssm	9	412	2.2%	cbioportal
9	SF3B1	Ssm	9	412	2.2%	cbioportal
10	SMARCA4	Ssm	8	412	1.9%	cbioportal
14	NTRK2	Ssm	7	412	1.7%	cbioportal
13	NF1	Ssm	7	412	1.7%	cbioportal
12	FOXO1	Ssm	7	412	1.7%	cbioportal
11	BRCA2	Ssm	7	412	1.7%	cbioportal
15	PTCH1	Ssm	7	412	1.7%	cbioportal
17	PTEN	Ssm	6	412	1.5%	cbioportal
16	APC	Ssm	6	412	1.5%	cbioportal
18	FBXW7	Ssm	5	412	1.2%	cbioportal
19	TSC2	Ssm	5	412	1.2%	cbioportal
25	TSC1	Ssm	4	412	1%	cbioportal
22	MSH6	Ssm	4	412	1%	cbioportal
21	KEAP1	Ssm	4	412	1%	cbioportal
20	CTNNB1	Ssm	4	412	1%	cbioportal
24	STK11	Ssm	4	412	1%	cbioportal
26	U2AF1	Ssm	4	412	1%	cbioportal
23	NTRK1	Ssm	4	412	1%	cbioportal
28	FGFR2	Ssm	3	412	0.7%	cbioportal
27	AKT1	Ssm	3	412	0.7%	cbioportal
29	PIK3CA	Ssm	3	412	0.7%	cbioportal
30	RB1	Ssm	3	412	0.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-28

Pancreatic Cancer (UTSW, Nat Commun 2015) paad_utsw_2015UTSW

109 cases with simple somatic mutation data · 109 cases total · 2026-01-12 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	100	109	91.7%	cbioportal
2	TP53	Ssm	55	109	50.5%	cbioportal
3	SMAD4	Ssm	21	109	19.3%	cbioportal
4	ZNF814	Ssm	20	109	18.3%	cbioportal
5	MUC16	Ssm	17	109	15.6%	cbioportal
6	TTN	Ssm	16	109	14.7%	cbioportal
7	MUC2	Ssm	12	109	11%	cbioportal
8	FLG	Ssm	11	109	10.1%	cbioportal
9	MIA2	Ssm	11	109	10.1%	cbioportal
10	MUC5B	Ssm	10	109	9.2%	cbioportal
11	OBSCN	Ssm	9	109	8.3%	cbioportal
12	ATXN1	Ssm	8	109	7.3%	cbioportal
13	COL18A1	Ssm	8	109	7.3%	cbioportal
14	HERC2	Ssm	8	109	7.3%	cbioportal
15	KRT4	Ssm	8	109	7.3%	cbioportal
16	NEBL	Ssm	8	109	7.3%	cbioportal
17	NF1	Ssm	8	109	7.3%	cbioportal
18	PCMTD1	Ssm	8	109	7.3%	cbioportal
19	AHNAK2	Ssm	7	109	6.4%	cbioportal
20	ARID1A	Ssm	7	109	6.4%	cbioportal
21	COL14A1	Ssm	7	109	6.4%	cbioportal
22	DGKB	Ssm	7	109	6.4%	cbioportal
23	FAT3	Ssm	7	109	6.4%	cbioportal
24	FOLH1	Ssm	7	109	6.4%	cbioportal
25	KMT2C	Ssm	7	109	6.4%	cbioportal
26	LILRB3	Ssm	7	109	6.4%	cbioportal
27	MAGEC1	Ssm	7	109	6.4%	cbioportal
28	MUC17	Ssm	7	109	6.4%	cbioportal
29	MUC4	Ssm	7	109	6.4%	cbioportal
30	NBPF9	Ssm	7	109	6.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Ductal Adenocarcinoma (CPTAC, Cell 2021) paad_cptac_2021CPTAC

140 cases with simple somatic mutation data · 140 cases total · 2026-01-12 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	135	140	96.4%	cbioportal
2	TP53	Ssm	105	140	75%	cbioportal
3	CDKN2A	Ssm	29	140	20.7%	cbioportal
4	SMAD4	Ssm	24	140	17.1%	cbioportal
5	CTNNA2	Ssm	13	140	9.3%	cbioportal
6	MUC4	Ssm	13	140	9.3%	cbioportal
7	TTN	Ssm	12	140	8.6%	cbioportal
8	RYR2	Ssm	10	140	7.1%	cbioportal
9	RNF43	Ssm	9	140	6.4%	cbioportal
10	ARID1A	Ssm	8	140	5.7%	cbioportal
11	KMT2D	Ssm	8	140	5.7%	cbioportal
14	GNAS	Ssm	7	140	5%	cbioportal
15	MUC16	Ssm	7	140	5%	cbioportal
16	RBMXL3	Ssm	7	140	5%	cbioportal
17	SYNE1	Ssm	7	140	5%	cbioportal
13	FMN2	Ssm	7	140	5%	cbioportal
12	DNAH9	Ssm	7	140	5%	cbioportal
29	TAF1L	Ssm	6	140	4.3%	cbioportal
28	RYR3	Ssm	6	140	4.3%	cbioportal
26	PXDNL	Ssm	6	140	4.3%	cbioportal
27	RBM10	Ssm	6	140	4.3%	cbioportal
18	ANKRD30B	Ssm	6	140	4.3%	cbioportal
19	CDH10	Ssm	6	140	4.3%	cbioportal
20	CSMD1	Ssm	6	140	4.3%	cbioportal
21	DOCK2	Ssm	6	140	4.3%	cbioportal
22	GLI3	Ssm	6	140	4.3%	cbioportal
23	IRX2	Ssm	6	140	4.3%	cbioportal
24	KMT2C	Ssm	6	140	4.3%	cbioportal
25	LRP1B	Ssm	6	140	4.3%	cbioportal
30	ZFHX4	Ssm	6	140	4.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-12