NUTM1 — gene · CancerIndex

Curated evidence

Clinical evidence (14)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–14 of 14 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NUTM1 Fusion6
(diagnostic)	NUT CarcinomaALIAS	Diagnostic	B	Supports Positive	4	accepted	EID12049 In this 2017 study, the authors sought to characterize NUT carcinomas. They included a cohort of 12 aggressive malignant tumors with rearrangement of the NUTM1 gene, assessed by RT-PCR, FISH, positive… (full text at CIViC) PMID 28643357 · Lemelle et al., 2017 · Open in CIViC	civic
〃	NUT CarcinomaALIAS	Diagnostic	B	Supports Positive	3	accepted	EID7019 5 of 28 cases of undifferentiated carcinomas of the upper aerodigestive tract (UCUAT) not associated with EBV infection were found to have NUTM1 rearrangements suggesting NUT midline carcinoma may be… (full text at CIViC) PMID 18391746 ·

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Pediatric Pan-cancer (Columbia U, Genome Med 2016) mixed_pipseq_2017	unmapped	Ssm	14	103	13.6%

Literature

Linked publications (11)

25 per page, newest first.

pubmedPublishedShowing 1–11 of 11 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

NUT carcinoma in children and adults: A multicenter retrospective study.
· Pediatr Blood Cancer · 2017 · PMID 28643357 · validated civic_curation pubmed
An Anatomical Site and Genetic-Based Prognostic Model for Patients With Nuclear Protein in Testis (NUT) Midline Carcinoma: Analysis of 124 Patients.
· JNCI Cancer Spectr · 2020 · PMID 32328562 · validated civic_curation pubmed
Midline carcinoma of children and young adults with NUT rearrangement.
· J Clin Oncol · 2004 · PMID 15483023 · validated civic_curation pubmed
NUTM1 is a recurrent fusion gene partner in B-cell precursor acute lymphoblastic leukemia associated with increased expression of genes on chromosome band 10p12.31-12.2.
· Haematologica · 2019 · PMID 30872366 · validated

NUTM1 Fusion7
(diagnostic)	NUT CarcinomaALIAS	Diagnostic	B	Supports Positive	4	accepted	EID12050 In this 2020 study, the authors included a total of 141 NUT carcinomas defined by rearrangement of NUTM1 detected by IHC, cytogenetics, FISH or sequencing. The median age at diagnosis was 24 years (ra… (full text at CIViC) PMID 32328562 · Chau et al., 2020 · Open in CIViC	civic
〃	NUT CarcinomaALIAS	Diagnostic	B	Supports Positive	4	accepted	EID12051 In this 2004 study, the authors sought to identify carcinomas with translocation t(15;19)(q13, p13.1), which results in the novel oncogenic fusion BRD4::NUTM1 (described as NUT). The authors screened … (full text at CIViC) PMID 15483023 · French et al., 2004 · Open in CIViC	civic
〃	B-lymphoblastic Leukemia With NUTM1 RearrangementUNRESOLVED	Diagnostic	B	Supports Positive	4	accepted	EID12237 In this 2019 study, the authors investigated the association between NUTM1 rearrangements and B-lymphoblastic leukemia (B-ALL) in a cohort of pediatric and infant patients, up to 14 years of age. NUTM… (full text at CIViC) PMID 30872366 · Hormann et al., 2019 · Open in CIViC	civic
〃	B-lymphoblastic Leukemia With NUTM1 RearrangementUNRESOLVED	Diagnostic	B	Supports Positive	4	accepted	EID12238 In this 2021 study, the authors examined the diagnostic features of NUTM1-rearranged B lymphoblastic leukemia (B-ALL) in a cohort of infants and children. Among 161 KMT2A-wildtype infants, 21.7% were … (full text at CIViC) PMID 34211097 · Boer et al., 2021 · Open in CIViC	civic
〃	B-lymphoblastic Leukemia With NUTM1 RearrangementUNRESOLVED	Diagnostic	B	Supports Positive	4	accepted	EID12239 This 2021 study highlights the diagnostic significance of NUTM1 rearrangements in infants with B lymphoblastic leukemia (B-ALL) negative for KMT2A rearrangements. Among the 30 analyzed cases of KMT2A-… (full text at CIViC) PMID 33512459 · Fazio et al., 2021 · Open in CIViC	civic
〃	NUT CarcinomaALIAS	Diagnostic	C	Supports Positive	2	accepted	EID12009 RNA sequencing identified NUTM1 fusions in six patients with primary undifferentiated soft tissue and visceral tumors. Fusions included BRD4::NUTM1 (three cases), BRD3::NUTM1, MXD1::NUTM1, and BCORL1… (full text at CIViC) PMID 29356724 · Dickson et al., 2018 · Open in CIViC	civic
Molibresib	NUT CarcinomaALIAS	Predictive	B	Supports Sensitivity Response	3	submitted	EID12055 NUT carcinoma is known to be driven by BET fusion proteins, including BRD4::NUTM1 and BRD3::NUTM1, raising the possibility of response to BET inhibitors. Of 19 patients with NUT carcinoma treated wit… (full text at CIViC) PMID 32328561 · Piha-Paul et al., 2020 · Open in CIViC	civic