NUT Carcinoma

In this 2017 study, the authors sought to characterize NUT carcinomas. They included a cohort of 12 aggressive malignant tumors with rearrangement of the NUTM1 gene, assessed by RT-PCR, FISH, positive… (full text at CIViC)

PMID 28643357 · Lemelle et al., 2017 · Open in CIViC

5 of 28 cases of undifferentiated carcinomas of the upper aerodigestive tract (UCUAT) not associated with EBV infection were found to have NUTM1 rearrangements suggesting NUT midline carcinoma may be… (full text at CIViC)

PMID 18391746 · Stelow et al., 2008 · Open in CIViC

In the clinic, compassionate use of the BET inhibitor birabresib (also known as OTX015 or MK-8628) induced rapid tumor regression in 2 of 4 patients with confirmed BRD4-NUTM1 fusions and significant d… (full text at CIViC)

PMID 26976114 · Stathis et al., 2016 · Open in CIViC

Treatment of the patient-derived 797 NMC cell line for 48 hours with JQ1 (500 nM) provoked terminal differentiation which was accompanied by growth arrest and sustained inhibition of proliferation. … (full text at CIViC)

PMID 20871596 · Filippakopoulos et al., 2010 · Open in CIViC

BRD4-NUT fusion was found to be associated with globally decreased histone acetylation and transcriptional repression in gain-of-expression and loss-of-expression assays. Following these results, it w… (full text at CIViC)

PMID 21447744 · Schwartz et al., 2011 · Open in CIViC

A 10-year-old male patient with NUT Midline Carcinoma (NMC) harbouring the BRD4-NUT fusion gene was treated with vorinostat, an HDAC inhibitor, at a daily dose of 400 mg. In patient-derived NMC cells,… (full text at CIViC)

PMID 21447744 · Schwartz et al., 2011 · Open in CIViC

In this 2020 study, the authors included a total of 141 NUT carcinomas defined by rearrangement of NUTM1 detected by IHC, cytogenetics, FISH or sequencing. The median age at diagnosis was 24 years (ra… (full text at CIViC)

PMID 32328562 · Chau et al., 2020 · Open in CIViC

In this 2004 study, the authors sought to identify carcinomas with translocation t(15;19)(q13, p13.1), which results in the novel oncogenic fusion BRD4::NUTM1 (described as NUT). The authors screened … (full text at CIViC)

PMID 15483023 · French et al., 2004 · Open in CIViC

RNA sequencing identified NUTM1 fusions in six patients with primary undifferentiated soft tissue and visceral tumors. Fusions included BRD4::NUTM1 (three cases), BRD3::NUTM1, MXD1::NUTM1, and BCORL1…