Publication
Differentiation of NUT midline carcinoma by epigenomic reprogramming.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerNUT Carcinomacivic_curation1.00
- drugPanobinostatcivic_curation1.00
- geneNUTM1civic_curation1.00
- variantNUTM1 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 21447744
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| NUTM1 Fusion2 | ||||||||
| Panobinostat | NUT CarcinomaALIAS | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID12099BRD4-NUT fusion was found to be associated with globally decreased histone acetylation and transcriptional repression in gain-of-expression and loss-of-expression assays. Following these results, it w… (full text at CIViC) PMID 21447744 · Schwartz et al., 2011 · Open in CIViC | civic |
| Vorinostat | NUT CarcinomaALIAS | Predictive | C | Supports Sensitivity Response | 3 | submitted | EID12100A 10-year-old male patient with NUT Midline Carcinoma (NMC) harbouring the BRD4-NUT fusion gene was treated with vorinostat, an HDAC inhibitor, at a daily dose of 400 mg. In patient-derived NMC cells,… (full text at CIViC) PMID 21447744 · Schwartz et al., 2011 · Open in CIViC | civic |