CIC-Rearranged Sarcoma — Variants & evidence

CIC-Rearranged Sarcoma — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

5 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
DUX4 Fusion4
(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID9012 This study consists of a cohort of 115 patients with a class of sarcomas that had similar morphology to Ewing sarcoma. The presence of a CIC rearrangement was detected in all the cases by FISH. Previo… (full text at CIViC) PMID 28346326 · Antonescu et al., 2017 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	3	accepted	EID11594 The authors recognize that differentiating between Ewing sarcoma and CIC::DUX4 fusion associated sarcoma can be challenging due to overlapping histological and immunohistochemical phenotypes. In this… (full text at CIViC) PMID 35151033 · Song et al., 2022 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	3	accepted	EID11595 In this 2012 paper, 22 small blue round cell tumors that remained unclassified after screening for known sarcoma-related translocations, were analyzed for CIC and FUS rearrangements. 68% (15/22) were… (full text at CIViC) PMID 22072439 · Italiano et al., 2012 · Open in CIViC	civic
(oncogenic)	Oncogenic	C	Supports Oncogenicity	3	accepted	EID10112 Kawamura-Saito, et al. (2006) presented 2 soft tissue Ewing-like sarcoma cases (62 years of age female who deceased 10 months after biopsy; 31 years of age male who was without recurrence 30 months af… (full text at CIViC) PMID 16717057 · Kawamura-Saito et al., 2006 · Open in CIViC	civic
NUTM1 Fusion + NUTM2B Fusion + DUX4 Fusion + LEUTX Fusion + NUTM1 Fusion + NUTM2B Fusion + DUX4 FusionDUX4 LEUTX NUTM1 NUTM2B1
(diagnostic)	Diagnostic	B	Supports Positive	4	submitted	EID12515 The cohort included 44 CIC-rearranged sarcomas (CIC-RS), comprising 18 central nervous system (CNS) and 26 extra-CNS tumors. RNA sequencing (n=27) identified CIC::DUX4 (n=15), CIC::NUTM1 (n=4), CIC::L… (full text at CIViC) PMID 39985394 · Koo et al., 2025 · Open in CIViC	civic

Data updated 23 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.