LEUTX

leucine twenty homeobox

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
LEUTX Fusion1
(diagnostic)	Childhood Central Nervous System Embryonal CarcinomaALIAS	Diagnostic	B	Supports Positive	2	submitted	EID12698 Across a multicenter cohort of CNS embryonal tumors (n = 9), recurrent BRD4::LEUTX fusions were identified by RNA sequencing, with all cases retaining LEUTX exon 2 and variable BRD4 breakpoints (exons… (full text at CIViC) PMID 38500181 · Andreiuolo et al., 2024 · Open in CIViC	civic
NUTM1 Fusion + NUTM2B Fusion + DUX4 Fusion + LEUTX Fusion + NUTM1 Fusion + NUTM2B Fusion + DUX4 FusionDUX4 LEUTX NUTM1 NUTM2B1
(diagnostic)	CIC-Rearranged Sarcoma	Diagnostic

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

Data not yet available

No cohort frequency recorded for this gene.

Literature

Data not yet available

No publication linked to this gene yet.

LEUTX Fusion1
(diagnostic)	Childhood Central Nervous System Embryonal CarcinomaALIAS	Diagnostic	C	Supports Positive	2	submitted	EID10310 This is a report about CIC-LEUTX gene fusion (CIC exon 20 to LEUTX exon 3 ) in a CNS embryonal tumor from a 2-year-old male, and the report also reviewed the clinical and pathological features of 3 ot… (full text at CIViC) PMID 33344249 · Hu et al., 2020 · Open in CIViC	civic