Gene

FLT3

fms related receptor tyrosine kinase 3

Explore in graph →CI-GENE-00002044HGNC:3765 ENSG00000122025 NCBI 2322 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (266)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 251–266 of 266 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
FLT3 Y842C7
FLT3/ABL/Aurora Kinase Inhibitor KW-2449	Acute Myeloid LeukemiaCURATED_BROADER	Predictive	D	Supports Resistance

Cohorts

Alteration frequency by cohort (125)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved125 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Acute Myeloid Leukemia (OHSU, Cancer Cell 2022) aml_ohsu_2022	Acute Myeloid Leukemia	Ssm	278

Literature

Linked publications (46)

25 per page, newest first.

pubmedPublishedShowing 1–25 of 46 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Gilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AML.
· N Engl J Med · 2019 · PMID 31665578 · validated civic_curation pubmed
Prognostic significance of FLT3 internal tandem duplication, nucleophosmin 1, and CEBPA gene mutations for acute myeloid leukemia patients with normal karyotype and younger than 60 years: a systematic review and meta-analysis.
· Ann Hematol · 2014 · PMID 24801015 · validated civic_curation pubmed
Midostaurin approved for FLT3-mutated AML.
· Blood · 2017 · PMID 28546144 · validated civic_curation pubmed
DNMT3A mutations in acute myeloid leukemia.
· N Engl J Med · 2010 · PMID 21067377 · validated civic_curation pubmed

FLT3 Y842H1
(predisposing)	Acute Myeloid LeukemiaCURATED_BROADER	Predisposing	C	N/A N/A	1	submitted	EID8929 Single strand polymorphism targeting FLT3 in addition to RUNX1, KIT, CEBPA, PTPN11, and NRAS was carried out to identify novel recurring gene mutations in an acute myeloid leukemia cohort comprised of… (full text at CIViC) PMID 15667533 · Smith et al., 2005 · Open in CIViC	civic

FLT3 Y842H1

(predisposing)

Acute Myeloid LeukemiaCURATED_BROADER

Predisposing

N/A N/A

submitted

EID8929

Single strand polymorphism targeting FLT3 in addition to RUNX1, KIT, CEBPA, PTPN11, and NRAS was carried out to identify novel recurring gene mutations in an acute myeloid leukemia cohort comprised of… (full text at CIViC)

PMID 15667533 · Smith et al., 2005 · Open in CIViC

civic

FLT3 Fusion1
CHOP Regimen	Myeloid/Lymphoid NeoplasmUNRESOLVED	Predictive	C	Supports Sensitivity Response	4	submitted	EID13101 This study describes a 71-year-old woman with myeloid/lymphoid neoplasm with eosinophilia and T-cell lymphoblastic lymphoma associated with a novel GOLGB1::FLT3 fusion from t(3;13)(q13;q12). Despite t… (full text at CIViC) PMID 27795560 · Troadec et al., 2017 · Open in CIViC	civic

FLT3 Fusion1

CHOP Regimen

Myeloid/Lymphoid NeoplasmUNRESOLVED

Predictive

Supports Sensitivity Response

submitted

EID13101

This study describes a 71-year-old woman with myeloid/lymphoid neoplasm with eosinophilia and T-cell lymphoblastic lymphoma associated with a novel GOLGB1::FLT3 fusion from t(3;13)(q13;q12). Despite t… (full text at CIViC)

PMID 27795560 · Troadec et al., 2017 · Open in CIViC

civic

FLT3 Fusion1
(diagnostic)	Atypical Chronic Myeloid LeukemiaALIAS	Diagnostic	C	Supports Positive	4	submitted	EID13106 This study describes a novel MYO18A::FLT3 fusion in a 47-year-old male with mixed myelodysplastic/myeloproliferative features. He presented with leukocytosis, splenomegaly, and atypical chronic myeloi… (full text at CIViC) PMID 30559310 · Zhang et al., 2018 · Open in CIViC	civic

FLT3 Fusion1

(diagnostic)

Atypical Chronic Myeloid LeukemiaALIAS

Diagnostic

Supports Positive

submitted

EID13106

This study describes a novel MYO18A::FLT3 fusion in a 47-year-old male with mixed myelodysplastic/myeloproliferative features. He presented with leukocytosis, splenomegaly, and atypical chronic myeloi… (full text at CIViC)

PMID 30559310 · Zhang et al., 2018 · Open in CIViC

civic

FLT3 Fusion1
Bone Marrow Transplantation + Donor Lymphocyte InfusionSequential	Atypical Chronic Myeloid LeukemiaALIAS	Predictive	C	Supports Sensitivity Response	4	submitted	EID13100 This study describes a 32-year-old female with atypical chronic myeloid leukemia (aCML) and a complex translocation [(t(2;13;2;21)(p13;q12;q33;q11.2)] resulting in a novel in frame SPTBN1::FLT3 fusion… (full text at CIViC) PMID 17764812 · Grand et al., 2007 · Open in CIViC	civic

FLT3 Fusion1

Bone Marrow Transplantation + Donor Lymphocyte InfusionSequential

Atypical Chronic Myeloid LeukemiaALIAS

Predictive

Supports Sensitivity Response

submitted

EID13100

This study describes a 32-year-old female with atypical chronic myeloid leukemia (aCML) and a complex translocation [(t(2;13;2;21)(p13;q12;q33;q11.2)] resulting in a novel in frame SPTBN1::FLT3 fusion… (full text at CIViC)

PMID 17764812 · Grand et al., 2007 · Open in CIViC

civic

FLT3 Fusion1
(diagnostic)	Myeloid/Lymphoid NeoplasmUNRESOLVED	Diagnostic	C	Supports Positive	3	submitted	EID13109 A 37-year-old male presented with a persistent sore throat, tonsillitis and cervical lymphadenopathy. Lymph node biopsy showed a T-lymphoblastic leukemia and bone marrow showed hypercellular marrow wi… (full text at CIViC) PMID 42171857 · Cook et al., 2026 · Open in CIViC	civic

FLT3 Fusion1

(diagnostic)

Myeloid/Lymphoid NeoplasmUNRESOLVED

Diagnostic

Supports Positive

submitted

EID13109

A 37-year-old male presented with a persistent sore throat, tonsillitis and cervical lymphadenopathy. Lymph node biopsy showed a T-lymphoblastic leukemia and bone marrow showed hypercellular marrow wi… (full text at CIViC)

PMID 42171857 · Cook et al., 2026 · Open in CIViC

civic

FLT3 Fusion1
(diagnostic)	Myeloid/Lymphoid NeoplasmUNRESOLVED	Diagnostic	C	Supports Positive	3	submitted	EID13102 A 62-year-old man presented with chronic eosinophilic leukemia and systemic mastocytosis. Cytogenetic analysis revealed t(13;14)(q12;q32), with genome and RNA sequencing confirming a novel TRIP11::FLT… (full text at CIViC) PMID 29025582 · Chung et al., 2017 · Open in CIViC	civic

FLT3 Fusion1

(diagnostic)

Myeloid/Lymphoid NeoplasmUNRESOLVED

Diagnostic

Supports Positive

submitted

EID13102

A 62-year-old man presented with chronic eosinophilic leukemia and systemic mastocytosis. Cytogenetic analysis revealed t(13;14)(q12;q32), with genome and RNA sequencing confirming a novel TRIP11::FLT… (full text at CIViC)

PMID 29025582 · Chung et al., 2017 · Open in CIViC

civic

FLT3 Fusion1
(diagnostic)	Myeloproliferative NeoplasmCURATED_BROADER	Diagnostic	C	Supports Positive	3	submitted	EID13108 A 64-year-old man presented with splenomegaly, peripheral eosinophilia, and bone marrow findings consistent with myeloproliferative neoplasm with eosinophilia. Cytogenetic analysis identified a balanc… (full text at CIViC) PMID 32866288 · Zhou et al., 2020 · Open in CIViC	civic

FLT3 Fusion1

(diagnostic)

Myeloproliferative NeoplasmCURATED_BROADER

Diagnostic

Supports Positive

submitted

EID13108

A 64-year-old man presented with splenomegaly, peripheral eosinophilia, and bone marrow findings consistent with myeloproliferative neoplasm with eosinophilia. Cytogenetic analysis identified a balanc… (full text at CIViC)

PMID 32866288 · Zhou et al., 2020 · Open in CIViC

civic

FLT3 Fusion2
(diagnostic)	Myeloproliferative NeoplasmCURATED_BROADER	Diagnostic	C	Supports Positive	4	submitted	EID13104 This study reported two cases of myeloproliferative neoplasm with eosinophilia harboring a ZMYM2::FLT3 fusion, which was cytogenetically cryptic and resulted from an approximately 8-Mb inversion. Case… (full text at CIViC) PMID 28751768 · Jawhar et al., 2017 · Open in CIViC	civic
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	4	submitted	EID13112 This study investigated the rare ZMYM2::FLT3 fusion in myeloid/lymphoid neoplasm with eosinophilia and tyrosine kinase gene fusions. Here lentiviral vectors containing the fusion gene and negative con… (full text at CIViC) PMID 40767405 · Liang et al., 2025 · Open in CIViC	civic

FLT3 Fusion2

(diagnostic)

Myeloproliferative NeoplasmCURATED_BROADER

Diagnostic

Supports Positive

submitted

EID13104

This study reported two cases of myeloproliferative neoplasm with eosinophilia harboring a ZMYM2::FLT3 fusion, which was cytogenetically cryptic and resulted from an approximately 8-Mb inversion. Case… (full text at CIViC)

PMID 28751768 · Jawhar et al., 2017 · Open in CIViC

civic

(functional)

—UNRESOLVED

Functional

Supports Gain Of Function

submitted

EID13112

This study investigated the rare ZMYM2::FLT3 fusion in myeloid/lymphoid neoplasm with eosinophilia and tyrosine kinase gene fusions. Here lentiviral vectors containing the fusion gene and negative con… (full text at CIViC)

PMID 40767405 · Liang et al., 2025 · Open in CIViC

civic